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Biomedical subjects

O E Ozcan

Publications and source records attributed to O E Ozcan.

At least 19 recordsLinked to original sources
PubMed1995

Congenital nasal encephalocele: a review of 35 cases.

Congenital encephaloceles are rare lesions which are usually seen in the occipital region, in the West. They may rarely be seen in the frontal region and they have distinct diagnostic features, together with several other pathological conditions occurring in this region. In order to emphasize these points, a retrospective analysis of 35 cases which have been operated on in our clinic, is made in this study. The findings are compared with the data obtained from the literature.

Bone Transplantation↗
PubMed1994

Preventive effect of intracisternal heparin for proliferative angiopathy after experimental subarachnoid haemorrhage in rats.

Proliferative angiopathy represents the morphological basis of delayed cerebral vasospasm. The initial vasoconstriction and endothelial damage of the vasospastic arteries leads to an exaggerated response of the smooth muscle cells within the media leading to subintimal thickening and myonecrosis. Heparin reduces the exposure of the media to platelet derived growth factor, a mitogen from aggregating platelets responsible for the migration and proliferation of the myofibroblasts. Since systemic heparin in the setting of a subarachnoid haemorrhage would be unacceptable, we have tested the effect of heparin on proliferative angiopathy by injecting autologous non-heparinized blood into two groups of rats (N = 12 each) and then inject the heparin into the spinal fluid of one group after one hour. We were able to show histologically that intracisternal heparin injection after the subarachnoid haemorrhage has reduced the vascular wall changes to a great degree. Heparinization of the cerebrospinal fluid carried out in conjunction with early operation for aneurysms may be a promising approach to prevent the morbid complications of SAH in the clinical setting.

Animals↗
PubMed1992

Congenital lumbosacral lipomas presenting as a form of occult spinal dysraphism. A report of 9 surgically treated cases.

Nine cases of congenital lumbosacral lipoma have been diagnosed and treated surgically at the Hacettepe University School of Medicine, Department of Neurosurgery during the last 16 years. Five patients were male and four female with ages ranging from 18 months to 30 years. The most frequent complaints were mass in the back (in five cases), motor weakness in the lower extremities (in five), urinary incontinence (in five), and lumbosacral hypertrichosis (in five). On neurological examination, four patients had deep tendon reflex changes, five had motor changes and four were normal. There was significant improvement in seven cases. Two had no improvement. In this report, we review nine patients retrospectively, and discuss the surgical intervention and the results achieved.

Adolescent↗
PubMed1991

Occipital depression fractures in childhood. A report of 14 cases.

In this paper, we present 14 cases with depression fracture of the occipital bone in pediatric age. There were 7 males and 7 females. Their ages ranged from 1 year to 15 years with a median of 5.8 years. The most common causes were: falling (8 cases); traffic accidents (2); assault (2 cases). Five of our 14 cases had compound fractures and the remaining 9 had closed fractures. Epidural and subdural hematomas were observed in 5 and 1 cases, respectively. There was significant improvement in 11 cases; two patients died.

Adolescent↗
PubMed1991

Effects of hydrocephalus on the sympathetic nerves of cerebral arteries, investigated with WGA-HRP anterograde tracing in the rat.

The effects of hydrocephalus on the plexus of sympathetic nerves of the intracranial vessels were investigated using wheat germ agglutinin combined with horseradish peroxidase (WGA-HRP). Hydrocephalus was induced by injection of kaolin into the cisterna magna of rats. Three weeks later the superior cervical ganglion (SCG) of one side received WGA-HRP. Three days later the circle of Willis and the contralateral superior cervical ganglion were dissected out. The intensity of labelling and density on the cerebral vessels and the number of labelled neurons on the contralateral superior cervical ganglion were calculated. The intensity of labelled nerves and thick bundles were significantly decreased, although tracing the nerve fibers throughout the length of the vessels was possible. The number of labelled neurons in the contralateral superior cervical ganglion indicated that the injection technique of WGA-HRP into the ganglion was correct in all rats. These results are in favour of the assumption, that the hydrocephalus related incomplete adrenergic denervation of the sympathetic perivascular nerve plexus was mainly due to neuropraxia of the nerve fibers rather than anatomical interruption of the axons.

Animals↗
PubMed1991

CNS involvement in Ewing's sarcoma. A report of 12 cases.

Ewing's sarcoma is one of the malignant bone tumours, which occurs in various bones of the body. When the spinal column or skull bones are involved, it may cause spinal cord compression or brain invasion. In this study, 12 cases of Ewing's sarcoma with central nervous system (CNS) involvement are presented. Seven of them were male and five female. In seven of the cases tumoural mass was located in the spinal column, whereas in the others it was found in the cranium. The major complaints were motor weakness in the lower extremities in seven cases, and a mass on the cranial vault in four cases. On neurological examination, eight of the patients had impairment of movements of the extremities (67%), and seven had sensory loss (58%). All except one patient underwent surgery. In seven cases, decompressive laminectomy plus subtotal tumour excision was performed, in three, craniectomy with grossly total tumour excision, and in one, biopsy. In this report, age and sex distribution, complaints, clinical and laboratory findings, neurological examination, and histopathology of our cases are reviewed and surgical results are compared with others reported in the literature.

Adolescent↗
PubMed1991

Low density in the posterior aspect of the intervertebral disk in the patient with herniated nucleus pulposus. A prospective study of 50 cases.

It was previously reported that a low density are in the posterior aspect of the intervertebral disk is an additional computed tomography (CT) finding suggesting a herniated nucleuos pulposus. In this report the incidence of this finding, its correlation with the duration of symptoms and severity of herniation, were studied on 59 herniated intervertebral disks of 50 cases.

Adult↗
PubMed1991

Surgery for progressive Pott's paraplegia (tuberculous paraplegia)

This is a study of 20 patients who had surgical intervention for Pott's paraplegia at the Hacettepe University Neurosurgery Department, Ankara. All patients were admitted with progressive paraparesis. Eleven patients had vertebrectomies, 5 laminectomies and in 4 patients costo-transversectomies were performed. The follow-up period ranged from 1 to 10 years. Thirteen patients were found to be normal at follow-up examinations (65%). In 4 patients there was some improvement in their neurological status, and the others had no improvement.

Adult↗
PubMed1991

Central neurofibromatosis. Case report and review of the literature.

An unusual case of central neurofibromatosis associated with a unilateral acoustic neuroma, multiple intracranial meningiomas, spinal neurofibroma and visceral involvement is presented. The progressive clinical course of this syndrome is described and discussed with a review of the relevant literature.

Brain Neoplasms↗
PubMed1991

Intracranial extension of meibomian gland carcinoma.

Meibomian gland carcinomas are rare, slow-growing masses that clinically mimic several benign and malignant processes. We report a patient with sebaceous carcinoma of the meibomian gland with intracranial extension and dural invasion, and discuss the clinical and pathological features of this uncommon entity.

Brain Neoplasms↗
PubMed1990

Multiple thoracic disc herniations.

Multiple thoracic disc herniation is a rare disease. There are only 12 cases reported in the literature. They were treated surgically. Two cases of multiple thoracic disc herniations subjected to laminectomy without discectomy are presented in this report.

Adult↗
PubMed1990

Aneurysmal bone cyst of the frontal bone.

Aneurysmal bone cyst rarely affects the skull. We report two cases of aneurysmal bone cyst of the frontal bone. One of the cases is associated with pregnancy. The association of pregnancy with aneurysmal bone cyst and enlargement of the aneurysmal bone cyst during the pregnancy have been discussed.

Adult↗