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Biomedical subjects

O Fakhri

Publications and source records attributed to O Fakhri.

At least 19 recordsLinked to original sources
PubMed1987

The therapeutic use of peritoneal macrophages in infected leukaemic patients.

Ten patients with acute leukaemia and infection unresponsive to antibiotics received single or multiple transfusions of peritoneal cells, mainly macrophages, obtained from donors undergoing peritoneal dialysis for renal failure. In six patients the cultures became negative and the temperature returned to normal and remained there, in two, there was temporary return of the temperature to normal and two patients showed no response. No significant side-effects were encountered. No changes in leukaemic blast cell numbers were seen in any of the patients.

Adolescent↗
PubMed1984

A note on xenogeneic transfusion of macrophages in experimental septicaemia.

Human peritoneal macrophages (M phi) were given intravenously to normal rabbits and rabbits with Escherichia coli septicaemia. No harmful effects were observed during a period of three months following macrophage transfusions and the septicaemia was eradicated in four of five animals. Thus xenogeneic M phi transfusion is feasible and can combat serious bacterial infections.

Animals↗
PubMed1981

Diabetes and ECT.

Explore the source record for details and available documents.

Blood Glucose↗
PubMed1980

Effect of electroconvulsive therapy on diabetes mellitus.

Of fourteen patients with diabetes mellitus, eight had complete remission of diabetic symptoms after one or two applications of elctroconvulsive therapy (ECT). In those who benefited the diabetes was of recent onset and non-insulin-dependent. One patient remains free from diabetes 14 years after ECT.

Adult↗
PubMed1978

Output of peritoneal cells during peritoneal dialysis.

Peritoneal dialysis provides a good source for the collection of macrophages. Six patients with chronic renal failure undergoing peritoneal dialysis for the first time were studied, and maximum cell egress, mostly macrophages, occurred at 24-48 hours and diminished after 48 hours.

Ascitic Fluid↗
PubMed1973

Overcoming some limiting factors in tumour immunotherapy.

Immunotherapy using rat 7s antibodies against plasmacytoma 5563 in C3H mice has been measured carefully. Prior adsorption of antibodies with normal mouse tissues, and supplements of co-optable non-immunized macrophages and lymphocytes enhanced the scope of immunotherapy against established tumours. It is suggested that available co-optable lymphocytes and macrophages are imporant limiting factors in tumour immunotherapy.

Adsorption↗
PubMed1970

Studies of the rat immune response to plasmacytoma 5563 in C3H mice.

Washed lymphocytes from immunized rats showed no reaction against mouse plasmacytoma 5563 in vivo or in vitro.Cell-free lymph from immunized rats was shown to be cytotoxic to the tumour cells in vitro. This effect we have shown to be solely in the 19s fraction after Sephadex G-200 separation.This 19s fraction conferred partial protection to tumour bearing mice when given shortly after transplantation, but had negligible effect against late well established tumour.

Animals↗
PubMed1970

The growth characteristics of an ascitic plasmacytoma (MP 5563) terminating by fistulous communication with the blood-stream.

The growth of ascitic mouse plasmacytoma 5563 has been monitored by (51)Cr-RBC dilutions within the peritoneal cavity together with differential cell counts and protein measurements.Following the intraperitoneal transplantation of one million tumour cells, there is a latency period of 4 days, possibly explained as only a 5% survival of the inoculum. This is followed by logarithmic growth from 4 to 8 days with a doubling time of 18 hours, always similar in different animals. Eventually after 8 days and after about 100 million cells an asymptote is reached which is due to a fistula-like communication between blood-stream and peritoneal cavity. This terminal phase (9-10 days) is rapidly followed by death of the mouse.Reliable tumour cell counts can only be achieved between 4 and 8 days.

Animals↗