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Biomedical subjects

O Filimon

Publications and source records attributed to O Filimon.

10 recordsLinked to original sources
PubMed1983

[Malignant tumorous urogenital fistula. Apropos of 19 cases].

Malignant tumors were responsible for 19 cases of urogenital fistula, including 10 ureterovaginal and 9 vesicovaginal fistulae, treated between 1974 and 1982. Details of the cases are reviewed and the therapeutic attitude to adopt towards urogenital fistulae of malignant tumor origin discussed. Recommended steps are: repeat plastic surgery as soon as possible after the postoperative appearance of the fistula, conservation of the kidney for as long as possible, and small intestine replacement of the ureter in selected cases. External as compared with internal urinary shunts are preferred in cases of advanced lesions with renal failure, tumor recurrence, or cobalt therapy. Cutaneous ureterostomy in Y with a single median or right lateral skin opening appears to be an excellent bypass procedure enabling a left colostomy to be performed, either primarily or secondary in case of rectal invasion.

Adult↗
PubMed1981

[Early repair of rupture of the posterior urethra in males. Report on 10 cases (author's transl)].

Repair operations were performed in 10 men with recent ruptures of the posterior urethra, between 1972 and 1980. One-stage segmental urethrectomy and end-to-end urethrorrhaphy was performed immediately (5 cases) or deferred to a late date (5 cases), with (2 cases) or without (8 cases) protective cystostomy. The origin of the lesions in these cases is discussed. The results obtained in these 10 patients are compared with those observed in 6 other cases treated urgently by cystostomy, with or without perineal drainage, followed by urethral reconstruction after a period of 2 to 6 months. Healing occurred within a mean period of 27 days in the first group, and 185 days in the second. Urinary fistulae developed in 20 p. cent of the patients in the first group, and 17 p. cent of those in the second group. Urinary continence was good in 100 p. cent of the first and 67 p. cent of the second group, a sterile urine being obtained in 100 p. cent and 83 p. cent of cases respectively. Sexual disorders were reported in 10 p. cent of the first and 67 p. cent of the second group. The authors conclude that urgent immediate or deferred reconstruction should be conducted in recent ruptures of the posterior urethra in men. Micturition urethrography after IVU. and retrograde urethrography, are essential investigations for detecting the lesions. Retrograde urethrography should be conducted with a small quantity (10 ml) of contrast medium, as soon as possible after plastic surgery. The authors employ segmental urethrectomy followed by end-to-end urethrorrhaphy, which has given better results than Solovov-Badenoch's urethroplasty.

Adult↗
PubMedDate not supplied

[Recent data about the LDL-atherogenesis relationship].

The steps în pathophysiology of ATS make easier the understanding of waves of processes that lead to the disfunction of the endothelial cells, hypertrophy of the arterial wall and în the end to the complication which drawn from this process. Atherogenic process which is characterised by proaterofenethic and atherogenetic mechanism imbalance suppose three phases: early, transition and terminal phase. The initial phase involve the focal influx and LDL-cholesterol accumulation în the arterial intima, the ROS (reactive oxygen species) and azot generation by smooth muscular cells, macrophages and endothelial cells and oxidative modification of LDL. Scientific data revealed that LDL oxidation is mediated by peroxinitrite (ONOO) anion which could act directly over the thiol groups or indirectly through OH and NO radicals from peroxinitrous acid breakdown and who initiate the polyunsaturated fatty acids peroxidation and the oxidation of apolipoprotein B-100. LDL completely oxidated are recognised by scavenger receptors which are not regulated by up and down regulation. The last event of the early atherogenic process is the formation of foam cells from macrophages through LDL modified captation by scavenger receptors.

Arteriosclerosis↗
PubMedDate not supplied

[Malignant infiltrating bladder tumors. Comments on 157 cases].

157 cases of malignant infiltrative tumors of urinary bladder admitted and treated in a 5-year interval (1983-1988) are presented. Considerations on age, sex, urological history, associated urological disorders, symptoms and clinical examination, diagnostic methods, surgical procedures and their association with other non-surgical procedures, postoperative evolution, pathological examination of the resection sample, tumoral stage, recurrences are made. Five cases treated by various methods are presented in detail. The clinical and laboratory diagnosis, therapeutical methods and the staged therapeutical indications are also commented upon. In the malignant infiltrative tumors of urinary bladder the authors recommend the partial cystectomy which, when correctly indicated and performed, gave similar results as total cystectomy. It is also underlined that in case of an urographically silent kidney the attitude should be conservative and the treatment of the malignant infiltrative tumors of urinary bladder should be multimodal.

Aged↗
PubMedDate not supplied

[Essential arterial hypertension in patients with non-insulin-dependent diabetes mellitus during and after balneotherapy followed-up for 6 years].

The statistical correlations between body weight, glycemia, total lipids, cholesterol in 200 patients with essential hypertension, especially borderline essential hypertension, followed up for 6 years indicate that the complex environmental factors in Slănic-Moldova Health Resort associated with balneotherapy may induce a return to normal values of the above mentioned parameters. Good results were also obtained in the patients with essential hypertension and non-insulin dependent diabetes mellitus, their treatment including reduction diets (1200-1400 calories/day).

Balneology↗
PubMedDate not supplied

[The surgical results in traumatic cataract].

The retrospective analysis of the postoperative course in 204 traumatic cataracts (140 isolated, simple cataracts and 64 aggravated ones) showed an apparent functional improvement in the simple cases (preoperative and postoperative visual acuity 0.0139 and 0.8520, respectively); the incidence of postoperative detachment of retina was of 4.9%, that of postoperative endophthalmitis that of cystoid macular edema of 3.2%; complications more commonly occurred in aggravated traumatic cataracts and partially accounted for the poorer functional results. During the investigated interval (1988-1992) a rapid shift to extracapsular cataract extraction and posterior chamber lens implants was made. The crystalline grafts preserved binocular vision in 92% of the cases and contact lens in 50% of the cases. Lens implant remains a matchless solution for the visual rehabilitation of the patients with aphakia.

Cataract↗