O G Paulsen | PubMed Health

PubMed2004

Sevoflurane-induced malignant hyperthermia during cardiopulmonary bypass and moderate hypothermia.

A 56-year old man was admitted for elective mitral valve repair and coronary artery bypass surgery due to mitral valve leakage and unstable angina. After induction of anaesthesia he developed a combined metabolic and respiratory acidosis. Different diagnosis were considered and we decided to treat the patient with dantrolene due to suspicion of malignant hyperthermia (MH). The patient received one dose of dantrolene 2,5 mg/kg during cardiopulmonary bypass (CPB) and a second dose of dantrolene 2,5 mg/kg during weaning from CPB. The first arterial blood gas sample taken in the intensive care unit showed relapse of the acidosis and we administered an infusion of 150 mg dantrolene over 3 hours. The patient gradually recovered without sequel and MH was verified by muscle biopsy testing.

Anesthetics, Inhalation↗

PubMed1978

Schizophrenia and communication efficiency. A modified replication taking ecological variation into consideration.

An earlier study (Sølvberg & Blakar (1975)) testified to subtle differences in communication efficiency over different communication situations by parental couples with and without schizophrenic offspring. The present study is offered as a replication of this study, but whereas the participating couples in the original study were recruited from a big city (Oslo), the parental couples in the present replication come from a typical rural district. The main findings of the original study are reproduced, but the very same method which was sensitive with respect to the "normality-schizophrenia" variable, also proved to be highly sensitive with regard to the cultural variation represented by the rural-urban dimension. Therefore, the present study is used as basis for discussing more general methodological problems involved in communication-oriented studies on psychopathology. In particular the underlying (often implicit) model of "normal communication", from which pathological communication deviates, is seriously questioned.

Communication↗