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O Günther

Publications and source records attributed to O Günther.

86 records · Page 5Linked to original sources

Intracerebroventricular administration of insulin attenuates retrieval of a passive avoidance response in rats.

The effect of intracerebroventricularly applied insulin on one-trial learning passive avoidance behaviour has been studied in rats. Treatment with 10.3 pmole insulin 1 hr before the 24 hr retention test attenuated passive avoidance behaviour at both the 24 hr and 48 hr retention trials. The data suggest that insulin may play a role in processes relating to the retrieval of information stored in the brain.

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Opposite effects of intraventricular and intracisternal administration of vasopressin on blood pressure in rats.

Lysine-8-vasopressin (LVP) was injected into the lateral ventricle (ICV) or into the cisterna magna (c.m.) of ether-anesthetized rats. ICV injection of LVP decreased the blood pressure (BP), whereas c.m. administration increased it. The opposite effects of ICV versus c.m. administration of the peptide might be related to differences in brainstem versus limbic-midbrain structures in the regulation of blood pressure, and suggest that both mechanisms can be influenced by vasopressin.

Animals↗

Influence of intracerebroventricularly and intracisternally administered vasopressin on the hypothalamic self-stimulation rate of the rat.

Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LVP diminished the self-stimulation rate after cisternal administration only. The findings suggest that the site of peptide administration is of decisive importance to vasopressin-induced effects. Both biochemical factors and the interaction between behaviour and vegetative nervous system should be taken into consideration when interpreting changes in self-stimulation as induced by vasopressin applied to the CSF space.

Animals↗