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Biomedical subjects

O Goetz

Publications and source records attributed to O Goetz.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Diagnosis of Pneumocystic carinii pneumonia by lavage of the bronchial system (author's transl)].

This report deals with a 10 year old girl suffering from an acute lymphoblastic leukemia since 1971. The child was hematologically in full remission, when she developed a pneumonia due to pneumocystis carinii. The diagnosis was established by demonstrating the agent in bronchial secretions. The material was obtained by rinsing the bronchial system. The patient was treated with pentamidine and co-trimoxazol (Bactrim) with good success.

Bronchi↗
PubMed1976

[Virus infections during immunosuppression (author's transl)].

Virus infections during immunosuppression are like those with congenital defective immunity. Humoral and cellular immunity and interferon production are affected. In children the primary infection is prominent, in adults the reactivation. Cytomegaly, varicella, herpes and herpes simplex are given as examples of virus infections due to treatment. If the lymphocyte count falls below 500/ml, the virus infection threatens to become generalized. The possibilities of effective therapy are still very small at present. Warning is given against the use of cytosine arabinoside.

Adrenal Cortex Hormones↗
PubMed1976

[Mouse cytomegalovirus infection under cytosine arabinoside treatment].

The antiviral activity of cytosine arabinoside (ARA-C) against the mouse cytomegalovirus was investigated in animal experiments using various dosages. The substance did not exhibit any virostatic effect, but on the contrary fostered the viral infection. The virus concentration in the liver after administration of five dosages of 30 mg/kg of cytosine arabinoside was 35 times higher than that in untreated animals, and after five dosages of 45 mg/kg was 70 times higher. In addition the mortality rate for infected animals treated with cytosine arabinoside was significantly higher in relation to dosage. Cytosine arabinoside also acts as an immunosuppressor in humans. Adverse effects in cytomegalo-infection can therefore not be excluded. The use of cytosine arabinoside in therapy would thus appear to be highly questionable.

Animals↗
PubMed1975

An improved specific IgM antibody assay for Epstein-Barr virus.

A new method for detecting specific IgM antibodies to the Epstein-Barr virus using indirect fluorescence is presented. The procedure is simple and reproducible, and of great value for the diagnosis of an acute infection. The number of positive cells is higher than in the Epstein-Barr IgG test. It would seem that it is possible to detect a positive IgM-specific antigen with this new test.

Antibodies, Viral↗