Biomedical subjects

O H Hansen

Publications and source records attributed to O H Hansen.

At least 55 records · Page 3Linked to original sources

PubMed1976

Billroth I gastric resection versus truncal vagotomy and pyloroplasty in the treatment of gastric ulcer.

Forty-five patients with benign gastric ulcers were treated by truncal vagotomy and pyloroplasty or Billroth I gastric resection in a randomized, controlled trial. Postoperatively, one Billroth I patient died. During the follow-up recurrence occurred in three patients treated by vagotomy, but in no Billroth I patient. The overall functional results according to the classification of Visick were slightly, but unsignificantly better after Billroth I than after vagotomy and pyloroplasty.

Aged↗

PubMed1976

Antral gastrin cells. A correlation between the number of gastrin cells and the total concentration of gastrin in serum and in antral mucosa. A pilot investigation.

Correlation between the gastrin cell number of delineated by immunohistological staining and the gastrin content in blood and antral mucosa has been studied in biopsies from the antral region of the human stomach. With a semiquantitative score system of the antral gastrin cells, we found correlation between the number of cells and the gastrin content in mucosa and serum and the grade of atrophic pyloric gastritis in 52 patients with different gastric diseases. It is concluded that further studies will be necessary before it is possible to estimate the total mass of gastrin cells and thereby compare different clinical groups.

Adult↗

PubMed1976

Cell proliferation kinetics in normal human gastric mucosa. Studies on diurnal fluctuations and effect of food ingestion.

Cell proliferation of human gastric mucosa was studied in 3 healthy subjects. Biopsies were obtained from the antral and fundic part of the stomach through a fiber gastroscope. After in vitro incubation with tritiated thymidine, autoradiographs were prepared by the dipping technique. Labeling and mitotic indices were estimated. The number of DNA-synthesizing cells and the mitotic frequencies were higher in antral mucosa compared to mucosa in the fundic part of the stomach. Biopsies were taken after 12 hr of fasting and at various intervals during the following day. It was not possible to demonstrate any diurnal variations in the labeling and mitotic indices. Furthermore, biopsies were taken at various intervals after ingestion of a protein-rich meal, preceded by 12 hr of fasting. Significant changes in cell proliferation were not found either in antral or in fundic mucosa, indicating that a meal does not affect the rate of cell renewal in human gastric mucosa.

Adult↗

PubMed1975

[Thrombocytopenia, hypoxia and fat embolism syndrome after severe injury].

Explore the source record for details and available documents.

Adolescent↗

PubMed1975

A method to study cell proliferation kinetics in human gastric mucosa.

The purpose of this investigation was to study cell proliferation kinetics in human gastric mucosa. Biopsies were taken from the antral and fundic part of the stomach through a fibre-gastroscope and incubated in culture medium containing a DNA-precursor (3-H-thymidine). Autoradiographs were prepared by the dipping technique. The number of labelled cells and the total number of cells in all cross sections of foveolae containing one or more labelled cells were counted. The labelling index (LI), which is defined as the percentage of labelled cells in the progenitor cell region, was estimated. When only cross sections with labelled cells are taken into consideration, the labelling index will be a little overestimated. In order to reduce this error a formula for correction was worked out. Thirty-six patients with different gastric diseases were studied. The observer error was minimal, and the results were highly reproducible. It was not possible to demonstrate any correlation between the labelling indices in antral and fundic mucosa. A significantly increased epithelial proliferation was found in fundic mucosa from patients with gastric cancer and atrophic gastritis.

Adult↗

PubMed1975

Healing of duodenal and prepyloric ulcers after selective and highly selective vagotomy.

Thirty-six patients with duodenal or prepyloric ulcers who were treated by selective or highly selective vagotomy were followed up endoscopically. In one group of 21 patients examined 2 weeks after the operation, 67 per cent of the ulcers were healed. In another group of 15 patients endoscopy performed 2 months after the operation revealed that 93 per cent of the ulcers were healed. On comparing with previously reported endoscopical observations concerning spontaneous healing of duodenal ulcers, it can be concluded that vagotomy significantly promotes the healing of duodenal and prepyloric ulcers.

Adult↗

PubMed1975

Clinical course of cystosarcoma phyllodes related to histologic appearance.

A series of 17 females having cystosarcoma phyllodes underwent surgical treatment. The subsequent clinical course was observed periodically. Twelve patients had originally histologically benign tumors. Six patients had a recurrence, and of these, malignant characteristics developed in four instances. Five patients had originally histologically malignant tumors. Recurrences were encountered in four. Five patients died from a generalized spread of the tumor. Three of these patients had originally histologically benign tumors, in which malignant features of the recurrent tumor subsequently developed. The surgical treatment ranged from local excision to simple mastectomy with additional roentgenotherapy in three. Neither procedure prevented a recurrence from the original tumor, whether benign or malignant. Poor correlation exists between biologic behavior and histologic appearance of cystosarcoma phyllodes, independent of the surgical procedure. Wide local excision in histologically benign and mastectomy in histologically malignant tumors are advised, but no final decision could be reached. It is proposed to restrict ther term cystosarcoma phyllodes to histologically malignant tumors and use the term fibroadenoma phyllodes in instances of histologically benign tumors.

Breast Neoplasms↗

PubMed1974