[In vitro studies of the effect of zinc oxide and titanium dioxide on dermatophytes].
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Biomedical subjects
Publications and source records attributed to O H Paetzold.
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Cutaneous infection due to bacteria are predominantly caused by staphylococci. The sensitivity of 1036 staphylococcal strains towards various topical and systemical antibiotics was investigated over a period of three years (1973-1975). Comparing the present results with results from previous investigations revealed that staphylococcal sensitivity towards common antibiotic drugs remained nearly unchanged. A comparatively high proportion of strains has acquired resistance against multiple antibiotics. The importance of routinely determining bacterial sensitivity in antibiotic therapy is emphasized.
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In vitro effects of 2 water-soluble prednisolon-derivatives on 10 Candida albicans and 10 Candida tropicals species were investigated. Tests were performed during resting and proliferation phases. Changes of cell metabolism were measured by O2-consumption by the Warburg technique. With increasing corticosteroid concentrations (10-10000 gammaml) a dose dependent increase of cell respiration was found with and without addition of nutritive substrates. Even high concentrations of corticosteroid did not cause an antimetabolic effect. The tests did not yield different results for the two Candida species examined.
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