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Biomedical subjects

O Helmig

Publications and source records attributed to O Helmig.

14 recordsLinked to original sources
PubMed1989

[Bioaccessibility of diazepam administered as Valium and Valaxon tablets].

A double-blind, cross-over investigation undertaken of the bioaccessibility of diazepam in 12 healthy volunteers revealed that there is no significant difference as regards the bio-accessibility of diazepam administered as Valaxon or as Valium tablets. It is concluded that pharmokinetic studies such as this can provide important clinical information and are easy to carry out in a hospital department.

Adult↗
PubMed1988

Skeletal disease, arthro-osteitis, in adult patients with pustulosis palmoplantaris.

A follow-up study of 13 patients with pustulosis palmoplantaris (PPP) and skeletal disease is reported. A prolonged and fluctuating course occurred in all patients. Nine patients had anterior chest wall involvement with erosions or ankylosis of the sternoclavicular, first sternocostal and/or manubriosternal joint together with sclerosis and often hyperostosis of adjacent bones, ossification/calcification of the first costal cartilage, and in 7 patients of the costoclavicular ligament. Spinal involvement in the form of spondylodiscitis, sclerosis of vertebral bodies, syndesmophytes, paravertebral ossifications and/or spondyloarthritis occurred in 11 patients, three of whom also had involvement of the sacroiliac joints. One patient had sclerosis of a pubic and ischial bone. Peripheral arthritis or tenosynovitis occurred in 5 patients, two of whom had signs of enthesopathy, and one also erosions. The presence of a distinct PPP syndrome is suggested.

Adult↗
PubMed1984

Patellar pain treated by neurotomy.

The mechanism of patellar pain is still not fully understood. Many operative procedures have been proposed, but so far no single technique has been successful. Under the impression that some of the pain-relieving effect by operative treatment is due to partial denervation of the patella, a medial denervation of the patella was performed in 17 patients (20 knees), mean age 24 years, with patellar pain syndrome. At the follow-up only 11 knees were free of symptoms or had improved, and the authors conclude that though comparable with other surgical methods, medial neurotomy is not sufficient to eliminate the pain in patients with patellar pain syndrome.

Adolescent↗
PubMed1984

Computed tomography of the knee with reference to meniscal tears. A preliminary report.

CT scanning of the knee was performed in one patient with a Baker's cyst and normal menisci and 8 patients with meniscal tears diagnosed at arthrography and confirmed at arthrotomy. The normal menisci were clearly demonstrated. The torn parts of the menisci invariably had ill-defined free edges and contained areas of low CT attenuation. In 2 patients swelling peripheral to the torn meniscus was only demonstrated at CT.

Adolescent↗
PubMed1977

Primary leiomyosarcoma of bone.

A case of primary leiomyosarcoma of bone in the femur of an 18-year-old girl is described. Light and electron microscopy showed characteristic changes with cytoplasmic myofilaments, dense bodies, pinocytic vesicles and basal lamina fragments. Clinically, the patient is well and without evidence of tumor 9 months after the femur amputation without further treatment.

Adolescent↗
PubMedDate not supplied

Chronic recurrent multifocal osteomyelitis: a follow-up study.

Thirteen children/adolescents and two young adults with unifocal or multifocal nonpyogenic inflammatory bony lesions with a prolonged, fluctuating course are reported. The lesions were most often located at the metaphyseal region of tubular bones and the clavicle, but also at the spine, ischiopubic bone, and the sacroiliac joint. Progressive sclerosis and hyperostosis occurred mostly in the clavicle and occasionally in the tibia, femur, metatarsal, and ischiopubic bone, linking the changes to those described under the name Garré osteomyelitis. Seven patients had pustulosis palmoplantaris, and the skeletal disorder may be regarded a form of pustulotic arthroosteitis.

Adolescent↗
PubMedDate not supplied

Computed tomography of the knee with reference to meniscal tears. A prospective blind investigation.

Computed tomography (CT) with a high resolution CT scanner and--on a special occasion--double contrast arthrography of the knee with reference to meniscal tears were performed in 50 patients. Operation or arthroscopy was performed in 28 patients and 15 were found to have meniscal tears. A correct diagnosis of the tears was achieved at CT in 13 of these patients. Three false positive and two false negative CT findings were recorded, resulting in a 91 per cent accuracy for CT, a diagnostic specificity of 84 per cent, and a sensitivity of 95 per cent. The diagnostic value of CT thus compared with that of double contrast arthrography. This should indicate that CT may be used as an alternative non-invasive diagnostic procedure in the diagnosis of meniscal tears of the knee joint.

Adolescent↗