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Biomedical subjects

O Hutzinger

Publications and source records attributed to O Hutzinger.

At least 37 records · Page 2Linked to original sources
PubMed1976

The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation.

Incubation of 4'-chloro-4-biphenylol with a mushroom tyrosinase preparation gave the catechol, 4'-chloro-3,4-biphenyldiol as the sole in vitro metabolite. This compound was identical with the major rat urinary metabolite of 4'-chloro-4-biphenylol and thus confirms the structure assigned to the metabolite. This result also demonstrates a possible degradation pathway of hydroxylated chlorobiphenyls which are themselves the major metabolic degradation products of polychlorinated biphenyls.

Catechol Oxidase↗
PubMed1976

Environmental chemistry of substitutes for polychlorinated biphenyls. I. Composition and properties of an alkylchlorobiphenyl product.

The composition of a technical alkylchlorobiphenyl mixture, proposed as a substitute for polychlorinated biphenyls, has been investigated by spectral and chromatographic methods. Gas-liquid chromatography-mass spectrometry revealed the presence of a large number of biphenyls substituted with 2-3 chlorine atoms and 0-4 isopropyl groups. The mixture was dechlorinated as a first step toward structure elucidation of the individual components. The behavior of the alkylchlorobiphenyls during analytical cleanup steps such as thin layer chromatography and chromic acid oxidation was also investigated.

Alkylation↗
PubMed1975

The metabolism of 4'chloro-4-biphenylol in the rat.

4'Chloro-4-biphenylol, the major metabolite of 4-chlorobiphenyl in the rat, was given intraperitoneally to rats, and the urine and feces were examined for possible metabolic degradation products. The structure of the major urinary metabolite was elucidated by mass and nuclear magnetic resonance spectroscopy and shown to be 4'-chloro-3,4-biphenyldiol. Two chloromethoxbiphenylols (m-4) were also identified in the urine extracts but they could not be separated by chromatographic procedures. Demethylation of the mixture gave 4'-chloro-3,4-biphenyldiol as the sole product, thus indicating that the two components of the mixture were 4'-chloro-3-methoxy-4-biphenylol and 4'-chloro-4-methoxy-3-biphenyldiol. No 4'-chloro-4-biphenylol metabolites were isolated in the fecal extracts, and mass spectrometric analysis of the crude urine and feces extracts did not reveal any chlorine-containing degradation products that could be derived by oxidative fission of the biphenyl nucleus.

Animals↗