[Determination of test-model in the assessment of the effects of nitrate level on the body].
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Biomedical subjects
Publications and source records attributed to O I Tsyganenko.
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Nitrates entering the body of pregnant woman with food and potable water were showed to pass through the placental barrier and get into fetus. Transplacental transfer of nitrates under condition of nitrate overload on the body may result in development of hemic hypoxia, deterioration of biophysical profile of fetus and subsequently compromised infant's condition estimated by Apgar scale.
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Studies have been carried out developing the major issues of hygienic monitoring of nitrates in food-stuffs in the UkSSR: a unified republican system of hygienic control of nitrates content in food-stuffs with computer processing of the data has been proposed. Republican regulations of the allowed content of these substances in agricultural products are presented. Biomonitoring of nitrates in women's breast milk has been considered as a criterion of the system's functioning.
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The results of the investigations conducted have shown that most milk samples analyzed contained from 2 to 55.2 mg/l nitrates (P50 = 27.2 mg/l), dried milk and dry milk mixtures contained from 56.5 to 91.0 mg/kg nitrates (P50 = 72.9 mg/kg). The amount of nitrates detected in most products prepared at special milk centers for child nutrition did not exceed the mean level of nitrates in the whole milk. However, 12% of milk samples and 6% of dry milk mixtures contained significantly higher levels of nitrates. A conclusion has been made on the necessity of testing and regulation of nitrate content in the milk and milk products for child nutrition.
It has been shown that Polycar prepared from sodium carbonate byproducts, intended for the treatment of potatoes before its storage, makes for an increase in solanine content, and a decrease in the level of ascorbic acid in potato. Such potato produces a toxic effect on the rat body. A conclusion has been made that Polycar could not be used as an agent for potato treatment.
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Oxidative phosphorylation in the liver mitochondria of new-born and adult rats has been studied as affected by nitrates. It was established that the conjugation between the processes of respiration and phosphorylation is disturbed, energy efficiency of respiration in the liver mitochondria decreases in the new-born and adult animals. The found disturbances are more distinct in the new-borns that is evidenced by the dose-dependent effect under nitrate intoxications established in this group of animals.