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O J Repelaer van Driel

Publications and source records attributed to O J Repelaer van Driel.

29 records · Page 2Linked to original sources
PubMed1998

[The importance of steroid receptors for the prognosis and hormone treatment of breast cancer patients: a retrospective study in Southeastern Netherlands].

OBJECTIVE: To assess the effect of oestrogen (ER) and progesterone (PgR) receptors on the prognosis of patients with operable breast cancer and the decision to treat these patients with adjuvant tamoxifen. DESIGN: Retrospective. SETTING: Eight community hospitals in the Southeast Netherlands. METHOD: Using the registry of the Comprehensive Cancer Centre South, 2862 breast cancer patients were identified with stage I, II or IIIA tumours, treated during the period 1984-1992. RESULTS: ER and PgR status were known for 2393 (84%) and 1761 (62%) patients respectively. From 1991, over 80% of the postmenopausal, lymph node positive patients had received tamoxifen, irrespective of the steroid receptor status. Of all lymph node negative patients fewer than 3% received adjuvant systemic treatment. Among the lymph node negative patients the steroid receptor status was not a significant predictor of survival. Among the lymph node positive patients whose tumours were both ER-negative and PgR-negative, a 2.8-fold increased risk of death was found during the first four years after primary treatment. The risk of death was not increased if only the ER or only the PgR status was negative. CONCLUSION: This study shows that ER and PgR receptors are significant prognostic factors for survival in breast cancer patients with involved axillary lymph nodes. The prognostic effect appeared to be restricted to the first four years after primary treatment. Selection of patients for endocrine treatment should be based on the steroid receptor status, considering the importance of the steroid receptors for predicting the response to endocrine treatment.

Adult↗
PubMed1998

Metastasis in a benign duodenal stromal tumour.

Gastro-intestinal stromal tumour (GIST) is increasingly recognized as a distinct entity within the group of soft tissue tumours. Mostly, GIST arises from the muscular components of the stromal layer, but the tumour may also originate from the autonomic nerve system, recently designated as gastro-intestinal autonomic nerve tumour (GANT). The majority of GIST is located in the stomach and small intestine; only 4% of GIST is found in the duodenum. Clinical and pathological criteria to differentiate benign from malignant GIST are not well established. Tumour size and mitotic activity are commonly considered as important features, predicting biological behaviour and outcome. It has been suggested that the clinical course of the GANT-type tumours may be more aggressive. We present a case of a radically resected duodenal stromal tumour with benign features, in a young woman, with metastases to the liver and peritoneum occurring 8 years after the initial diagnosis.

Adult↗
PubMed1997

Changing attitudes towards breast-conserving treatment of early breast cancer in the south-eastern Netherlands: results of a survey among surgeons and a registry-based analysis of patterns of care.

To see whether personal preferences of surgeons can explain the trends in the use of breast-conserving therapy (BCT) of early breast cancer, questionnaires were sent to the surgeons of seven community hospitals in the south-eastern Netherlands in 1987 and 1995. The answers were set against the actual use of breast-conserving therapy in the hospitals in the period 1984-94, as monitored by the Eindhoven Cancer Registry. The proportion of surgeons who were willing to use BCT for tumours < or =3 cm increased from 43% in 1987 to 93% in 1995. In 1995, the majority of the surgeons considered multicentric tumour growth, diffuse microcalcifications on the mammogram and an extensive intraductal component around the tumour as contraindications for breast-conserving therapy. The proportion of patients with an operable, non-metastasized breast tumour of < or =5 cm in diameter undergoing breast-conservative surgery increased from 31% in 1984 to 60% in 1989 (P<0.01) and remained at that level in 1990 and 1991. Between 1991 and 1993, the proportion receiving breast-conservative surgery decreased significantly for patients younger than 50 years and a tumour 2.1-3.0cm in diameter, and also for those 50-69 years old with a tumour < or =2.0cm or 3.1-5.0cm across. The observed decrease in BCT in the south-eastern Netherlands in some subgroups seems to reflect the growing awareness of potential risk factors for local recurrence following BCT.

Adult↗
PubMed1995

[Local recurrence following breast-conserving treatment for breast carcinoma; treatment and prognosis in 82 patients].

OBJECTIVE: To evaluate the treatment and prognosis of 82 patients with local relapse in the breast as the first event after breast-conserving therapy of operable breast cancer. DESIGN: Descriptive and retrospective. SETTING: 17 general hospitals in southeast North-Brabant and North-Limburg. METHODS: Using the registries of the Comprehensive Cancer Centre South in Eindhoven (1981-1990) and the Bernard Verbeeten Institute in Tilburg (1981-1987), 82 patients were identified who had developed local recurrence after breast-conserving therapy. RESULTS: The mean age of the 82 patients at the time of detection of local recurrence was 51 years. 46 recurrences (56%) were localized at or near the site of the original tumour, 14 (17%) were detected elsewhere in the breast, 15 (18%) showed diffuse spread through the breast and seven (9%) were completely or partly localized in the skin. Nine recurrences (11%) were non-invasive. Of the 82 patients four received adjuvant systemic therapy only and no surgery. Of the 78 patients treated with surgery 72 underwent mastectomy, 6 local excision. After treatment, the actuarial five-year overall survival, distant recurrence-free survival and disease-free survival rates were 60%, 43% and 31% respectively. Local control, defined as survival without second local recurrence and without local progression of the disease, was 57% after five years. CONCLUSION: The five-year distant recurrence-free and disease-free survival rates for patients with local recurrence after breast conserving-therapy were low. The high proportion of second local recurrences and local progression of disease in this study underlines the difficulty of obtaining local control after treatment of local recurrence.

Adult↗
PubMed1994

Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer.

35 patients were studied to determine the effectiveness of scalp hypothermia in the prevention of alopecia caused by adjuvant chemotherapy for breast cancer. Scalp hypothermia was induced by the newly developed Theracool cooling machine. The chemotherapeutic regimen consisted of one perioperative course of doxorubicin 50 mg/m2, cyclophosphamide 600 mg/m2 and 5-fluorouracil 600 mg/m2 (EORTC protocol 10854). Only 4 (11%) patients showed acceptable hair preservation (no or minor alopecia). 12 patients (34%) had moderate alopecia, all requiring a wig. 19 patients (54%) had complete alopecia. No scalp metastases were observed after scalp cooling. These results and a review of the literature suggest that scalp hypothermia to prevent alopecia may only be effective in a cytotoxic regimen containing an anthracycline as the sole alopecia-inducing agent. With current adjuvant chemotherapy for breast cancer, in which a combination of cyclophosphamide and an anthracycline is often used, there is no place for scalp hypothermia.

Adult↗
PubMed1994

Management of early breast cancer in southeast Netherlands since 1984. A population-based study. Regional Breast Cancer Study Group.

We studied changes in staging and treatment of patients with early breast cancer (TNM stage I and II) in eight community hospitals in southeast Netherlands between 1984 and 1991 and related these changes to the guidelines for the management of breast cancer drawn up by the regional Breast Cancer Study Group. Since 1984, the proportion of patients that underwent breast-conserving therapy (local tumour excision, axillary dissection, and irradiation of the breast) increased from 26% to 53%. Although the mean number of axillary lymph nodes examined by the pathologists increased significantly, the proportion of patients with positive lymph nodes remained unchanged. The proportion of patients with involved axillary nodes receiving any form of adjuvant systemic therapy increased from 49% to 82%. Therapeutic policy initially varied significantly from one hospital to another but gradually became more uniform. We conclude that, except for elderly patients, treatment of early breast cancer corresponded increasingly to the guidelines of the regional Breast Cancer Study Group.

Adult↗
PubMed1988

Surgically implanted subcutaneous venous access devices in cancer patients.

Subcutaneously implanted venous access devices allow prolonged access with a minimum of discomfort for patients with inadequate peripheral veins or chemotherapy-induced recurrent thrombophlebitis. In 45 cancer patients, 49 venous access devices (Port-A-Cath) were implanted subcutaneously by means of a venous cut-down technique to avoid the risk of pneumothorax. Most catheters were implanted in the deltapectoral groove under local anaesthesia with lidocaine 0.5% and guided by fluoroscopy. The cumulative function time was 22.6 patient years (1177 weeks), the mean function time 24 weeks (range 0-98 weeks). No serious complications were seen. There were two local infections and four occlusions. The patency could be restored in three of these four. Surgical implantation of venous access devices, under local anaesthesia, is a safe method to establish central venous access in cancer patients. The complication rate is low in comparison with percutaneous catheters or AV-fistulas.

Anesthesia, Local↗
PubMed1977

Prevention of bleeding tendency after open-heart surgery for Tetralogy of Fallot.

Postoperative blood losses after open-heart surgery for Tetralogy of Fallot made re-operation imperative in 15 out of 44 patients (34%, Series A). A surgical bleeding point proved to be the causative factor in only 2 cases; the others were believed to be caused by disturbances of the haemostatic mechanism, particularly by low platelet counts, apparently due to extracorporeal circulation. Administration of a platelet suspension after disconnection of the extracorporeal circuit diminished the number of bleeding complications significantly: in a series of 58 patients (Series B), 8 re-operations (14%) were necessary. In 3 of these cases, technical reasons could be found for the blood losses. Haemodilution was carried out routinely in both series. However, the diluent contained a pasteurised protein solution in Series A and fresh frozen plasma in Series B in order to minimize the deficit of coagulation factors as much as possible.

Adolescent↗
PubMedDate not supplied

Lumbar sympathectomy for severe lower limb ischaemia: results and analysis of factors influencing the outcome.

Sixty consecutive patients (66 legs) underwent surgical lumbar sympathectomy as the only therapy for severe lower limb ischaemia (pain at rest and/or frank gangrene) caused by arteriosclerosis in the period 1977 to 1982. After six months results were good, as defined by absence of pain at rest, healing of ischaemic lesions and no major amputation, in 48% of limbs and bad in all other limbs. Patients with rest pain only fared much better than those with gangrene: after six months a major amputation had to be performed in 14% and 45% respectively. The presence or absence of diabetes mellitus and palpable pulsations at knee level and the angiographic patterns were of no help in the prediction of the results of lumbar sympathectomy. Doppler ankle/arm indices did have predictive value, since in all limbs with Doppler indices lower than 0.30 a major amputation had to be performed. Lumbar sympathectomy still remains a useful procedure in the treatment of selected patients with severe lower limb ischaemia in which reconstructive surgery is not feasible. But it is only advocated in the presence of ankle/arm indices above 0.30 and in the absence of gangrenous lesions.

Ankle↗