[Stability of 6 per cent Dextran Spofa].
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Biomedical subjects
Publications and source records attributed to O Jozová.
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The values of the absolute eosinophil count in certain laboratory animals were examined and were compared with values in healthy humans. The method and the results extend the possibility of detecting and studying changes in biological processes in the organism of experimental animals.
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Using gel filtration on Sephadex G 200, three fractions splitting N-acetyl-L-tyrosine ethyl ester (ATEE), termed I, S and II, were found in rat liver homogenate. In molecular size, electrophoretic mobility and thermolability, fractions I and II correspond to the ATEE-splitting enzymes contained in rat serum. The liver fraction S had a different surface electric charge and was relatively stable at high temperatures. Apart from ATEE, it splits certain ester and amide bonds of synthetic substrates. Purified fraction S increased vascular permeability in guinea pigs. Differential centrifugation of liver homogenate showed that fraction S and fractions I and II were localized differently in the subcellular particles.
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