Biomedical subjects

O K Abayomi

Publications and source records attributed to O K Abayomi.

5 recordsLinked to original sources

PubMed1996

Pathogenesis of irradiation-induced cognitive dysfunction.

Neurocognitive dysfunction is a common sequela of cranial irradiation that is especially severe in young children. The underlying mechanisms of this disorder have not been described. The present review describes the role of the hippocampus and the anatomically related cortex in memory function and its marked susceptibility to ischemic and hypoxic injury. Based on studies of animal models of human amnesia and histopathological findings in the irradiated brain, the neurocognitive sequela of cranial irradiation can be seen to be mediated through vascular injury, resulting in ischemia and hypoxia in the hippocampal region. Recognition of the site and mechanisms of this injury may lead to the development of techniques to minimize the risks.

Age Factors↗

PubMed1987

Late recurrent carcinoma of the cervix: a report of an unusual case and course.

A patient with late recurrence of squamous cell carcinoma of the cervix after full course irradiation is presented. The recurrence was extensive and not amenable to surgery. She was reirradiated utilizing special treatment techniques and fields which resulted in long-term survival with acceptable morbidity. The need for case selection and individualization of treatment for patients with late recurrence is discussed.

Carcinoma, Squamous Cell↗

PubMed1987

High dose irradiation for recurrent carcinoma of the cervix following radical hysterectomy.

A patient with recurrent carcinoma, after radical hysterectomy for Stage 1B carcinoma of the cervix, is presented to illustrate a technique for excluding the small bowel from high dose irradiation. With a barium meal and follow through examination, and fluoroscopy using the simulator, the ideal treatment position for the boost to high dose was determined. Consequently the patient received high dose irradiation with minimal complications and has survived for 42 months after treatment. Since a significant proportion of patients with recurrent carcinoma of the cervix have disease limited to the pelvis, many are potentially curable with high dose irradiation. Small bowel tolerance is a major dose limiting factor: the use of special techniques that limit the volume of small bowel receiving a high dose may enable these patients to have curative irradiation with minimal morbidity.

Adult↗

PubMed1986

The incidence of late endocrine dysfunction following irradiation for childhood medulloblastoma.

A retrospective analysis of treatment in 20 patients who had received post-operative radiotherapy for medulloblastoma between 1969 and 1977 was completed. The patients were followed for a minimum of 60 months. Eleven patients survived for 5 or more years after treatment. The patients received 3600 cGy to the whole brain. The posterior fossa received 5600 cGY and the spinal axis 3600 cGY. Eight of eleven patients developed growth impairment; 6 of 7 patients had growth hormone deficiency. Since all endocrine gland failures are amenable to therapy, early attention to patients' growth rate and detection of hypothalamic-pituitary failure, would be of benefit to longterm survivors.

Adolescent↗

PubMed1986

Computerized tomographic evaluation of tumors of the nasopharynx and maxillary sinus: potential impact on results of treatment.

A review of 23 consecutive patients with tumors of the nasopharynx and maxillary sinus seen over a two-year period was carried out. The purpose was to assess the value of computerized tomography (CT) in the definition of tumor extension to contiguous structures and its effect on treatment selection and management.CT was found to be very useful in detailing bone and soft-tissue invasion. In 11 of 15 patients with nasopharyngeal cancer and in the eight patients with maxillary sinus tumors, the selection of treatment and the techniques of irradiation were influenced by the CT findings.There is a high degree of accuracy in the evaluation to the nasopharynx and maxillary sinus by CT. This improvement in pretreatment assessment of the tumors enables adequate treatment to be offered. Since most of the failures of treatment are a result of local recurrence, improvement in local control is likely to result in improved survival.

Humans↗