Biomedical subjects

O Kättström

Publications and source records attributed to O Kättström.

4 recordsLinked to original sources

PubMed1984

Oral and topical adrenergic beta-receptor blockers in glaucoma treatment. A multicenter study.

In a long-term multicenter open randomized study of 103 patients with glaucoma or intraocular hypertension, oral propranolol combined with 2% pilocarpine was compared with 0.5% topical timolol also combined with 2% pilocarpine, with respect to the effects on intraocular pressure and other signs of glaucoma. The results showed that the hypotensive effects were highly significant and equal for both treatments. There were no significant differences between the 2 groups in the amount of cupping of the nerve head or the visual field defects developing during treatment. An additive hypotensive effect was recorded when both propranolol and timolol were combined with pilocarpine, which indicates the development of tolerance to both beta-blockers. Pulse rate and blood pressure were moderately reduced in both groups, both significantly more so in the propranolol group. The investigation indicates that when combined with pilocarpine the 2 adrenergic beta-receptor blockers are equally effective. We believe that oral propranolol can improve drug compliance in the treatment of glaucoma.

Administration, Oral↗

PubMed1983

A combination of oral and topical beta-blockers with additive effects on intraocular pressure.

In a double-masked randomised cross-over study the effect of adding oral propranolol (40 mg X 2) to topical timolol-treatment (0.5% X 2) was evaluated. Ten patients with glaucoma or ocular hypertension (totally 15 pathological eyes and 5 healthy) who had had topical timolol for at least 2 months received the coded oral treatment. A significant decrease of the intraocular pressure (3.68 +/- 0.72 SD, P less than 0.01) was observed in the timolol-treated eyes after the addition of the masked treatment with placebo/propranolol. Also the non-timolol-treated fellow eyes had a significant decrease of the intraocular pressure. It is suggested that this additive effects depends on a loss of efficacy of the topical beta-blocker caused by an increase in the number of beta-receptors and that the oral beta-blocker restores the degree of blocking to a more efficient level.

Administration, Oral↗

PubMed1982

Bilateral acute retinal necrosis.

Four patients who experienced the sudden onset of anterior uveitis with large keratic precipitates and dense vitreous opacities developed confluent yellow-white swellings and exudates in the peripheral retina and sheathing and obliteration of retinal arteries. After absorption of the exudates, atrophic patches in the peripheral retina and a funnel-shaped retinal detachment with many tears appeared. Angiograms showed retinal edema, fluorescein leakage from the choroid in the affected areas, and perivasculitis of the retinal arteries. Although treatment seemed unable to alter the course of the disease, in one case the retina reattachment after vitrectomy and filling of the vitreous space with silicone oil. Histopathologic studies disclosed extensive atrophy and degeneration of the outer retinal layers and pigment epithelium and occlusion of the retinal vessels. An infection may trigger the uveitis, leading to an autoimmune sensitization against rods and cones that causes severe local immune-complex disease and retinal vasculitis.

Adult↗

PubMed1981

Interaction of timolol and adrenaline.

In a prospective double-blind randomised trial the interaction of timolol and adrenaline was studied in 20 patients with open-angle glaucoma and exfoliative glaucoma. After pretreatment for at least 2 weeks with timolol eyedrops adrenaline was added in a double-blind manner, and the intraocular pressure was recorded during 4 days. The study showed a significantly additive hypotensive effect of adrenaline, which was more pronounced in patients with exfoliative glaucoma.

Clinical Trials as Topic↗