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Biomedical subjects

O Köse

Publications and source records attributed to O Köse.

13 recordsLinked to original sources
PubMed2004

Follicular mucinosis responding to isotretinoin treatment.

Follicular mucinosis is a rare disorder of unknown etiology characterized by accumulation of mucin in the sebaceous glands and outer root sheaths of the hair follicles. It is divided into a primary benign type and a secondary type mostly associated with lymphomas. No effective standard therapy for follicular mucinosis is available. We describe the case of a 21-year-old Caucasian male who had papules, nodules, and erythematous plaques on his left shoulder, left arm, and right scapular region. He was diagnosed as primary benign generalized follicular mucinosis, and treated with isotretinoin. Almost complete remission was achieved in 4 months.

Adult↗
PubMed2002

Comparison of a single 400 mg dose versus a 7-day 200 mg daily dose of itraconazole in the treatment of tinea versicolor.

BACKGROUND: Tinea (pityriasis) versicolor is a superficial infection of the stratum corneum by the lipophilic fungus known as Malassezia furfur. OBJECTIVE: To evaluate the efficacy and safety of a 400 mg single dose or 7-day 200 mg daily dose of itraconazole capsules in the treatment of mycologically confirmed pityriasis versicolor. METHODS: A total of 50 patients were entered into a randomized, open, clinical trial comparing a 400 mg single dose (n = 24 for group 1) with a 7-day 200 mg daily dose (n = 26 for group 2) of itraconazole. Clinical signs and symptoms and mycologic evaluation (potassium hydroxide preparation and Wood's lamp) were performed before treatment, and at weeks 3 and 6 after treatment. RESULTS: Both regimens of itraconazole were effective. Our results showed that there were no significant differences in efficacy and safety between the two treatment regimens (chi-square tests, p > 0.05). CONCLUSIONS: On the basis of these findings, a single dose of itraconazole 400 mg/day was as effective as the 7-day 200 mg daily dose in the treatment of pityriasis versicolor.

Adult↗
PubMed2001

Cerebral vein thrombosis in Behçet's disease.

Behçet's disease is a chronic, relapsing multisystem disorder, and nervous system involvement is one of the serious manifestations. Neuro-Behçet is rarely reported in children and may present with a wide variety of symptoms because the entire neuraxis may be affected. A case of cerebral vein thrombosis secondary to Behçet's disease is presented. The patient has recovered without any visual loss and had no complaints at 1-year follow-up.

Adolescent↗
PubMed2001

Focal epithelial hyperplasia treated with interferon alpha-2a.

BACKGROUND: Focal epithelial hyperplasia (FEH) is an uncommon benign oral condition that occurs mainly in young individuals of certain racial groups. METHODS: A 21-year-old Caucasian man presented with FEH of the oral mucosa. The patient was treated with interferon alpha-2a three times a week for 14 weeks intramuscularly (a total of 162 million units). RESULTS: At 2 months after the end of therapy, the papular lesions showed partial regression. CONCLUSION: This treatment modality should be used in cases with diffuse focal epithelial hyperplasia.

Adult↗
PubMed1999

The evaluation of technetium 99m-citrate scintigraphy in children with suspected appendicitis.

PURPOSE: The authors evaluated the use of technetium (Tc) 99m-citrate scan in 30 children whose diagnoses of appendicitis were unclear. METHODS: There were 17 boys and 13 girls (mean age 10.6 years). Nineteen of 30 patients had appendicitis confirmed at laparotomy and through histological examination, and 11 patients had other causes of acute abdominal pain. RESULTS: Children included in this study were similar with respect to age, duration of symptoms, temperature, white blood cell count, and the incidence of right lower quadrant tenderness. Sixteen children had positive scan for acute appendicitis, but 1 of them had false-positive. Fourteen children had negative scan, but 4 of them had false-negative. The calculated values were 78.9% (15 of 19), 90.9% (10 of 11), 83.3% (25 of 30), 93.7% (15 of 16), and 71.4% (10 of 14) for sensitivity, specificity, accuracy, positive prediction, and negative prediction, respectively, in this study. CONCLUSION: The authors suggest the use of 99mTc-citrate scan in children when the diagnosis of appendicitis using other methods is unclear.

Appendicitis↗
PubMed1998

Malformation of the epididymis in undescended testis.

During a 6-year period, 312 boys (mean age 4.7 years) underwent orchidopexy for cryptorchidism. A total of 388 epididymides were examined and the configurations were recorded as a prospective trial. This study consists of 166 ectopic testes and 222 undescended testes. The observed configurations of epididymides in the ectopic testes were: type 1a in 99 cases (59.6%), type 1b in 35 (21.1%), type 2 in 24 (14.5%), type 3 in 7 (4.2%), and type 4 in 1 (0.6%). There were no patients in the study with type 5 and 6 anomalies. The configurations of epididymides in the undescended testes were: type 1a in 105 (47.3%), type 1b in 63 (28.4%), type 2 in 26 (11.7%), type 3 in 13 (5.9%), type 4 in 5 (2.3%), type 5 in 7 (3.2%), and type 6 in 3 (1.4%). The data revealed that the incidence of epididymal abnormalities in undescended testes (41%) was higher than that in the ectopic testes (25.9%) (P < 0.05).

Adolescent↗
PubMed1997

Evaluation of 99mTc-citrate, 67Ga-citrate and 99mTc(V) dimercaptosuccinic acid for the scintigraphic visualization of acute appendicitis.

An experimental study was planned to evaluate 99mTc-citrate, 67Ga-citrate and 99mTc(V) dimercaptosuccinic acid (DMSA) as agents for the visualization of acute appendicitis. Appendiceal ligation was performed through a midline incision in 24 rabbits. Twenty-four hours later the animals were divided into three equal groups. The rabbits were injected through the aurical vein with 1 mCi (37 MBq) 99mTc-citrate in group I, 0.5 mCi (18.5 MBq) 67Ga-citrate in group II and 1 mCi (37 MBq) 99mTc(V) DMSA in group III. After 3 h, static images of the rabbits were obtained with a gamma camera. There were positive images in seven, six and five rabbits in groups I, II and III respectively. The image quality was better in group I than in the other groups. Also, the mean uptake in group I was significantly higher than those of other two groups (P < 0.05). There was no significant difference between groups II and III (P > 0.05). All rabbits had appendicitis confirmed histologically. In conclusion, these results show that 99mTc-citrate is preferable to 67Ga-citrate and 99mTc(V) DMSA for the differential diagnosis of acute abdominal inflammations such as appendicitis, because of higher concentration ratios, simple and rapid preparation, low cost, excretion mainly through the kidneys and fast blood clearance.

Acute Disease↗
PubMed1997

Mesenteric, omental, and retroperitoneal cysts in children.

OBJECTIVE: To report our experience in the management of mesenteric, omental, and retroperitoneal cysts. DESIGN: Retrospective study. SETTING: University department of paediatric surgery, Turkey. SUBJECTS: 10 children with mesenteric, omental, and retroperitoneal cysts. INTERVENTIONS: Laparotomy in all cases. MAIN OUTCOME MEASURES: Mode of presentation, imaging techniques, surgical intervention, histological examination, morbidity, and recurrence. RESULTS: The main presenting symptoms were abdominal distension and pain. A palpable abdominal mass was detected in 4 patients. Preoperative ultrasonography was done in 8 patients and showed a cystic mass in 7. All patients underwent laparotomy-6 as emergencies because of acute abdominal findings. The cysts were located in the small bowel mesentery in 6, in the retroperitoneum in 2, and in the omentum and the mesosigmoid in another 2. Operations included complete excision of the cyst in 5 and complete excision with intestinal resection in the other 5. There was only one recurrence of a retroperitoneal cyst that needed a second operation. CONCLUSION: Early recognition and appropriate treatment of these cysts are associated with a good prognosis, but long term follow-up is advisable because of the possibility of recurrence.

Child↗
PubMed1996

A comparative study of laser ablation and transurethral electroresection for benign prostatic hyperplasia: results of a 6-month follow-up.

OBJECTIVE: To compare the efficacy of standard transurethral electroresection of the prostate (TURP) and visual laser ablation in the treatment of benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: In a randomized prospective study, the prostate glands of 60 patients with symptomatic bladder outlet obstruction caused by BPH were treated with TURP or visual ablation with the Ultraline side-firing Nd:YAG laser; the patients were assessed using standard symptom scores, the measurement of residual urine and uroflowmetry both before and at 3 and 6 months after treatment. RESULTS: All patients in both treatment groups had a significant improvement in symptoms and objective measures of voiding. The laser treatment gave significantly better improvements in symptom score than did TURP (P = 0.034), but TURP produced significantly better peak urinary flow rates (P = 0.025). CONCLUSION: These early results indicate that laser ablation of BPH may be a good alternative in the surgical treatment of this disease.

Aged↗