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Biomedical subjects

O Kaiser

Publications and source records attributed to O Kaiser.

4 recordsLinked to original sources

[Disease and treatment in the Old Testament].

Throughout the Ancient Near East, supernatural forces were considered the cause of illness, and treatments were based on a collaboration between seers, doctors and exorcists. On the other hand, the health care system reflected in the Old Testament is remarkable different - replacing the various mystics with a single doctor, often a Levitical singer who also prayed for the sick. This development is rooted in the fundamental monotheism postulated in Deuteronomy, and the prohibition of every kind of mantic or magic practice other than Jahwistic prophecy. The Old Testament reflects a change in the basic conceptualization of illness: rather than an expression of divine wrath, it is seen as the outcome of human sin. Certain theological problems arose from this ideology, including the need to explain the infant and child mortality that was so common during this period. Such questions were partly answered centuries later, by the Hellenistic belief in an after-life. Yet the Greek period brought with it another set of questions, such as whether a patient should consult a doctor or only pray to the Lord. In the early part of the second century, Ben Sira offered an answer which has been normative for religious people up to the present day - to consult the one without neglecting the other.

Bible↗

[Not Available].

Due to an exceptional source it is possible to reconstruct the medical history of King Asarhaddon who reigned in Assyria between 681 and 669 BC. It makes it possible to diagnose that the king suffered from lupus erythematodus disseminatus, first announced in 672 and which led in 670 to a full outbreak of the condition. It also gives us an insight into the limits of medicine of that time in the treatment of various symptoms, and the interaction with magic which was typical of the times. We are able to observe the behaviour of the court officials including that of the personal physician towards the respectible and exceedingly sensitive and depressive patient.

Asia↗

Effects of rifampicin on the peripheral turnover kinetics of thyroid hormones in mice and in men.

The induction of mixed function hepatic oxygenases by rifampicin is known to increase the metabolic clearance rate (MCR) of T4. By performing T3 and rT3 kinetics we have shown that rifampicin also increases the MCR of T3 and rT3. Using the fall of serum T4 during TSH suppression as an indirect marker of the production rate (PR) of T4, we have demonstrated that there was no major change in monodeiodination nor any shift to either 5'- or 5-monodeiodination. Rifampicin stimulates in mice the mixed function hepatic oxygenases. However, we were unable to increase hepatic deiodinase activity (deiodinase type I) in this species. It is therefore possible that the increased MCR of T4 in man is not mediated by an increased conversion rate either. As mixed function hepatic oxygenases are known to increase hepatic conjugation it is suggested that rifampicin increases the biliary excretion of iodothyronine conjugates.

Adult↗