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Biomedical subjects

O L Barbarash

Publications and source records attributed to O L Barbarash.

At least 19 recordsLinked to original sources
PubMed2006

[The peculiarities of immune status of patients with coronary heart disease in the predoperative period during the individual year].

The aim of the study was to evaluate the influence of the individual annual cycle (IAC), a period from one birthday to another, on the immune status of patients with coronary heart disease (CHD). The subjects, 146 male CHD patients, were hospitalized to undergo coronary bypass surgery (CBS). The preoperative period in patients who were operated on in the 4th IAC trimester was characterized by significant changes in cell immunity parameters, such as a decrease in the relative number of T-lymphocytes, T-helpers, and NK cells, which was associated with a significant increase in the frequency of pyoseptic complications after CBS. During the 1st IAC trimester there was an increase in the functional activity of polymorphonuclear leucocytes and monocyte level elevation, which corresponded with an increase in the number of coronarogenic complications. The data obtained demonstrate the dependence of the immune index dynamics of CHD patients on their IAC.

Coronary Artery Bypass↗
PubMed2006

[Clinical application of spirapril in patients with arterial hypertension combined with chronic obstructive pulmonary disease].

In this study quadropril (Spirapril, Pliva) was given for 2 months to patients with arterial hypertension combined with chronic obstructive pulmonary disease. The results show that quadropril (6 mg/day) is highly effective as monotherapy in patients with mild and moderate hypertensive disease. Its effects appear as significant lowering of mean 24 hour systolic and diastolic blood pressure (BP), lowering of diurnal and nocturnal BP. Therapy with quadropril for 8 weeks did not impair parameters of external respiration, produced no negative action on lipid and carbohydrate metabolism, was well tolerated, and caused no considerable side effects.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed2005

[Thyroid diseases in reproductive-age women living in Shoria mountains].

AIM: To analyze prevalence and structure of thyroid pathology in women of reproductive age living in Shoria mountains. MATERIAL AND METHODS: The examination of 409 women aged 18 to 40 living in mountain Shoria included assessment of social status, heredity, actual nutrition, visit to endocrinologist, ultrasound investigation of the thyroid, tests for thyroid hormones (TTH, T3, T4) in the serum, antibodies to microsomal fractions, iodine concentrations in the morning urine. RESULTS: Significant prevalence of thyroid diseases (62.3%), high rate of diffuse nontoxic goiter of the second degree (18.0%), nodular nontoxic goiter (11.8%), autoimmune thyroiditis (6.3%), hypothyroidism (5.5%), low median of iodine excretion with urine in women refer mountain Shoria to the zone of goiter endemia. CONCLUSION: Among migrants thyroid morbidity is significantly higher than among the native population. Eradication of goiter endemia will promote reproductive health in this region.

Adolescent↗
PubMed2004

[Comparative characteristics of stress tests--bicycle ergometry test and psycho-emotional test--in patients with ischemic heart disease].

AIM: To compare efficacy bicycle exercise (BE) and psychoemotional tests (PET) in provoking myocardial ischemia and arrhythmia in patients with acute and chronic forms of ischemic heart disease (IHD). MATERIAL AND METHODS: BE and PET (mathematical count test) were performed in 108 IHD patients. 30 patients had stable effort angina (FC II-III), 48 patients had progressing effort angina and 30 patients were at the subacute stage of myocardial infarction. RESULTS: PET was less efficient in detection of myocardial ischemia but is more adequate in detecting episodes of painless ischemia and ventricular rhythm disorders compared to BE. The greatest differences in efficiency of the tests occurred in patients with acute forms of IHD. CONCLUSION: Application of different stress tests in IHD patients raises efficacy of detecting episodes of painful, painless myocardial ischemia and rhythm disorders, specifies mechanisms of coronary failure development.

Blood Pressure↗
PubMed2003

[Biorthythmological risk factors for progression of coronary heart disease].

The study was undertaken to study a role of periods of an individual annual cycle (IAC) (from the date of a birthday to the following one) and the season of a year in patients with coronary heart disease (CHD) in its progression. The study enrolled 52 patients with functional classes II and stable angina pectoris. Clinical and functional parameters were estimated by the data of bicycle ergometric test (BET), 24-hour monitoring (24-h M), ECG, and echocardiography. The vast majority of cases of progression of angina were observed in autumn and winter. Moreover, in patients with angina, the duration of silent ischemia significantly increased and heart rate variability decreased in winter and that of painful ischemia increased in autumn, as evidenced by 24-h M. Trimesters 1 (months 1 to 3 from the date of birth) and particularly IV (months 10 to 12 from the date of birth) have been found to be characterized by a poor course of CHD. Thus, in trimester IV, the duration of total, and silent ischemia significantly prolonged, as shown by 24-h M; episodes of latent coronary insufficiency increased in number, as evidenced by BET. Thus, the course of CHD is determined by a number of biorhythmological factors: the season of a year and the period of IAC.

Angina Pectoris↗
PubMed2002

[Connection between the season of year, season of birth, and trimester of the individual year in patients with ischemic heart disease at risk for myocardial infarction and its complications].

AIM: To clarify whether the periods of the individual year (from one birthday to another), season of the year, season of birth of patients with ischemic heart disease (IHD) are involved in development of myocardial infarction and its complications. MATERIAL AND METHODS: Case histories of 349 men hospitalized for acute myocardial infarction (MI) have been analysed. The analysis concerned the rate of MI onset in various seasons of the year, trimesters of the individual year (IY) and seasons of the patient's birth. RESULTS: Incidence of MI was higher in winter and summer. MI complications develop more frequently in spring. Trimester I and IV (months i-III and IX-XII since birthday) appeared more favourable for development of MI and its complications. Most favourable for IM was trimester III of IY, for MI complications--trimester II of IY. IM occurred more frequently in IHD patients born in autumn, complications in those born in summer. CONCLUSION: Development of MI and its complications is determined by a number of chronobiological factors: season of the year, season of the patient's birth and period of the individual year. This information is valuable in planning preventive measures.

Humans↗
PubMed2001

[The role of intracardiac hemodynamic parameters in prognosis of cardiac failure in myocardial infarction patients].

Two-dimensional echocardiography was used to study intracardiac hemodynamics (end systolic, end diastolic volumes and left atrial ejection fraction; end systolic, end diastolic volumes and left ventricular fraction; mean pressure in the pulmonary artery; myocardial mass of the left ventricle) in 49 patients 2, 10 and 30 days after onset of macrofocal myocardial infarction (MI). It was found that patients with and without cardiac failure after one year of the diseases significantly differed by volume and function of the left ventricle and atrium registered since MI day 2. Probability of cardiac failure in the postinfarction period may be estimated since the disease day 2 by an increase in the end-systolic and end-diastolic volumes and left ventricular ejection fraction. A restrictive type of left ventricular diastolic dysfunction is one of the early prognostic criteria of cardiac failure in postinfarction period.

Adult↗
PubMed2000

[Infective endocarditis: the course].

AIM: Epidemiological analysis of mortality due to infectious endocarditis (IE) and the disease evolution. MATERIAL AND METHODS: A retrospective analysis was made of 109 IE lethal outcomes for 1987-1996 basing on the results of autopsies performed in Kemerovo prosectorium. RESULTS: A significant trend to a rise in death rate of IE was registered. Among the deceased there is a higher proportion of old IE patients and patients with primary IE. Many of the patients died of staphylococcal IE, greater number of patients died of gram-negative infection and IE caused by injections of narcotic drugs. CONCLUSION: Long-term trends in IE evolution are described.

Adolescent↗
PubMed1999

[Clinical and prognostic significance of the degree of delayed ventricular function and vegetative regulation of cardiac rhythm in myocardial infarction patients].

Ventricular tachyarrhythmias (VT) are responsible for many sudden deaths in postmyocardial infarction (PMI) patients. The aim of the study was to investigate clinical and prognostic significance for such patients of delayed ventricular activity and vegetative regulation of cardiac rhythm. Signal-averaged ECG, mathematical analysis of cardiac rhythm with measurement of variation range, mode, index of regulatory systems tension, 24-h ECG monitoring were made in 90 patients with acute large-focal myocardial infarction (MI) on the disease day 1, 15, 40 and 365. Signal-averaged ECG registered on MI day 15 was found most informative for identifying the risk to develop VT. Combined application of diagnostic techniques brings more information than each of them alone.

Adult↗
PubMed1998

[Substantiation of patients' length stay in hospital after acute myocardial infarct].

AIM: To study and validate the duration of optimal hospital stay for postmyocardial infarction patients and to specify indications for their discharge. MATERIALS AND METHODS: The trial enrolled 187 patients with large- and small-focal acute myocardial infarction. The patients were divided into two groups by different speed of activization and hospital stay. RESULTS: There were no significant differences between the groups with different duration of hospital stay by working ability and invalidism. Temporary disability in patients who have undergone standard rehabilitation was longer than in patients on the shorter-program rehabilitation. Performance of exercise tests on day 14 distinguished patients with a favourable long-term prognosis who were candidates for shorter rehabilitation program. CONCLUSION: The program of quicker rehabilitation (a two-times decrease in the hospital stay) can be applied to patients with uncomplicated myocardial infarction without damage to their health.

Adult↗
PubMed1998

[Phenomenon of preoperative stress in patients with ischemic heart disease. Assessment of its clinical and prognostic significance].

AIM: To assess preoperative stress in patients with ischemic heart disease (IHD) and its influence on the course of early intraoperative period. MATERIALS AND METHODS: 79 patients scheduled for aortocoronary bypass operation were studied to assess the phenomenon of preoperative psychoemotional stress (clinical characteristics, personal anxiety, humoral and vegetative regulation. RESULTS: 24 hours before operation IHD patients became anxious, coronary insufficiency and arrhythmia aggravated as shown by Holter ECG monitoring. Initial insufficiency of the antioxidant system, disturbances of the platelet-vascular hemostasis, hyperlipidemia and dyslipoproteinemia enhanced. Preoperative changes due to stress reaction affected the course of early intraoperative period. CONCLUSION: It is necessary to apply individual schemes of stress-limiting preoperative preparation in IHD patients.

Adult↗
PubMed1998

[Clinical and occupational prognosis in myocardial infarction patients which were on different activation regimens and stayed in hospital for different time].

Two groups of patients with Q and non-Q myocardial infarction were compared: 105 patients who underwent early activization and were discharged early and 82 patients treated according to the routine 3-5-week program. The activization implied physical rehabilitation which took 2 times less time than the standard one. It is shown that disability of patients rehabilitated for shorter period of time was significantly shorter. The criteria allowing shorter hospitalization for myocardial infarction patients are proposed.

Adult↗
PubMed1997

[Late ventricular potentials and autonomic cardiac rhythm regulation in patients with acute myocardial infarction].

Relationship between late ventricular potentials (LVP) and vegetative regulation of cardiac rhythm was investigated in 52 patients with acute myocardial infarction. Using signal-averaged ECG and mathematical analysis of cardiac rhythm registered on infarction days 1, 15 and 40 it was found that by disease day 40 a direct correlation became more and more evident between inhibited ventricular activity and the intensity of sympathetic impacts on cardiac rhythm. Thus, the onset of ventricular arrhythmia in patients with myocardial infarction is resultant not only from the presence of arrhythmia substrate, but also from "the autonomic background".

Adult↗
PubMed1996

[The stress-modulating effects of laser therapy in IHD patients].

Dependence of the response to helium-neon laser therapy (LT) on initial level and changes of blood plasma hydrocortisone (HC), testosterone (T), diene conjugates (DC) concentration, general antioxidant activity (AOA) of blood plasma, TxB and 6-keto-PGF were estimated in 147 patients with ischemic heart disease and stable angina. The response to LT was observed in patients with high levels of HC, T, AOA and 6-keto-PGF1 alpha. A significant increase of DC was noted in these patients too. The minimal level of HC. T and AOA was recorded in patients with negative clinical effect. The treatment only aggravated HC, T and AOA deficiency and raised DC and TxB level. The findings suggest that the effect of LT is based on modulation of nonspecific adaptive mechanisms.

Adult↗
PubMed1990

[Changes in the superoxide dismutase activity during stimulation of polymorphonuclear leukocytes of peripheral blood].

The functional activity of the peripheral blood polymorphonuclear leukocytes (PML) was investigated by using the method of latex-stimulated luminol-dependent chemiluminescence (CL). The CL-intensity of PML taken from patients with acute myocardial infarction (MI) was found to be 20 times higher than that of normal individuals (NI). The change in activity of endogenous antioxidative enzyme systems may account for alteration of PML CL-parameters. It was established that the initial superoxide dismutase (SOD) activity of unstimulated PML from patients with MI exceeds that of NI, and that rapid increase in intercellular SOD activity (within 30 sec.) occurs in the process of PML stimulation. It was suggested that the change of SOD activity during PML stimulation was the result in the enzyme partial proteolysis in the cells. The positive correlation between initial level of SOD activity and CL-intensity of PML was observed. The investigation of the above parameters in MI dynamic showed a gradual normalization of PML CL-response and insignificant decrease in intracellular SOD activity in case of a favourable cause of the disease. Increased SOD activity in PMLs may be one of the factors contributing to a decrease in PML functional activity in the disease dynamic.

Adult↗