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Biomedical subjects

O L Deniston

Publications and source records attributed to O L Deniston.

4 recordsLinked to original sources

Assessment of quality of life in end-stage renal disease.

Ten different multi-item indexes and nine single-item measures were used to assess the quality of life of patients undergoing one of four major modalities of treatment for end-stage renal disease (ESRD). Assessments were made on a population-based sample of Michigan patients with onset of ESRD after November 1, 1981, during the period May 1984 to September 1986. The nature of these measures is described and correlations among them are reported. The correlations suggest that these indexes tend to represent either function or feeling, with moderate relationships within the two clusters but little between them. Findings are also reported in terms of age, race, and sex. Depending on the measure chosen to assess quality of life, different conclusions about the relationship of quality of life to these demographic characteristics will be reached. These conclusions may help readers think more critically about the nature of quality of life in arriving at judgments on the relative validity of these different measures.

Activities of Daily Living

Effect of long-term epoetin beta therapy on the quality of life of hemodialysis patients.

Differences in quality of life were observed using two separate patient populations with end-stage renal disease who were on maintenance hemodialysis. The first population (91 patients) received epoetin beta (Marogen Sterile Powder, Chugai-Upjohn, Inc., Chicago, Ill.) for an average of 18 months. The second population (96 patients) did not receive this therapy. The measured quality of life parameters included a number of global and psychological well-being measurements and the Sickness Impact Profile (SIP), as well as energy, activity levels, appetite, work, and sexual function. When adjusted for covariates (health status and demographics), 16 of 26 parameters were significantly higher (p less than .05) in patients receiving epoetin beta. All mean scores for global measurements were significantly higher. Significantly higher scores were also obtained for total SIP and total psychosocial subscale, as well as for sleep, home management, recreation, emotional behavior, social interaction, ability to work, and energy. While not statistically significant, all of the remaining measurements were higher for epoetin beta than for untreated patients.

Adult