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Biomedical subjects

O L Jensen

Publications and source records attributed to O L Jensen.

17 recordsLinked to original sources
PubMed1991

One year follow-up study on polymetacrylate and hydrogen intraocular lenses.

This study includes two selected groups of patients operated for cataract with implantation of either a polymetacrylate (PMMA, Sinskey J-loop, prolene haptics, Mod.102H, Pharmacia) or a soft hydrogel (IO-gel, Alcon) posterior chamber lens. There were 27 patients in the PMMA group and 32 in the hydrogel lens group. The study concludes that after 1 year of observation a comparison between the two groups disclosed no major difference concerning the visual outcome and influence on the ocular tissue. No substantial observations point towards the hydrogel lens as the more biocompatible of the two lenses.

Aged↗
PubMed1987

pH changes of the tear fluid in the conjunctival sac during postoperative inflammation of the human eye.

Conjunctival fluid pH was measured pre- and post-operatively in 16 patients suffering from senile cataract. We found a significant increase (P less than 0.05) from 7.26 +/- 0.23 (mean +/- SD) on the day before operation to 7.50 +/- 0.23 (mean +/- SD) on the first post-operative day in the conjunctival fluid of the treated eye. Thereafter a gradual decrease towards pre-operative level was observed. These changes were not observed in the healthy fellow eye (P greater than 0.05). No significant pre-operative difference was shown between the two eyes. It is reasonable to assume that the composition of the transudate/exudate from the conjunctival vessels might be responsible for the changes observed.

Adult↗
PubMed1987

Lactoferrin and serum albumin in the conjunctival fluid of eyes operated for senile cataract.

The concentrations of serum albumin (SA) in the conjunctival fluid were measured in 25 patients before surgery and in the post-operative period following cataract extraction. We found a significant increase in mean tear fluid SA concentration on the first post-operative day. The SA concentration remained high during the first 3 pre-operative levels. No correlation between the post-operative concentration profile of tear fluid SA and earlier findings of the tear lactoferrin (LF) profile of the same group of patients (Jensen et al. 1985) could be shown, although a trend towards an inverse relationship was apparent from the graphs. Pre-operatively, we found a significant positive correlation between age and concentration of SA in the conjunctival fluid (P less than 0.05) which might be interpreted as an increase in leakage from conjunctival vessels with age. This would, at least partly, explain the decreasing LF concentration with age (Jensen et al. 1986; McGill et al. 1984). It is concluded that transudate/exudate from the conjunctival vessels, represented by the change in the SA concentration in the conjunctival fluid, might be responsible for an initial post-operatively reduced concentration of LF and possibly other lacrimal gland proteins.

Adult↗
PubMed1986

The effect of polyvinylpyrrolidone-iodine as an disinfectant in eye surgery.

105 patients admitted for cataract surgery were treated pre-operatively with polyvinylpyrrolidone-iodine (PVP-I) as a disinfectant, and consecutive bacterial cultures were obtained before initiating surgery and at the end of the operation. A control group (n = 99) only had a standard disinfection procedure of the eye (including instillation of Terramycin cum polymyxin B cream in the conjunctival sac the evening before surgery). The cultures obtained from the conjunctival sac of the control group principally showed growth of Staph. albus and Staph. aureus, and to a minor degree diphtheroids (Corynebacterium species). Proteus mirabilis, Escherichia coli and micrococci. There was a significant quantitative diminished growth (P less than 0.05) of bacteria in the group of patients treated with PVP-I compared to the control group. Concerning the growth of Staph. albus, this was reduced to almost one third and other bacteria were almost eliminated in the group receiving PVP-I. As we disclosed no toxic or allergic reaction post-operatively which could be related to the use of PVP-I as a disinfectant, this agent seems to constitute an effective pre-operative antimicrobial treatment, taking into consideration the broad antimicrobial spectrum of PVP-I shown by other authors.

Adult↗
PubMed1986

The concentration of lactoferrin in tears of normals and of diabetics.

The tear lactoferrin content and the tear secretion rate was determined in 105 normal subjects (age range: 15-93 years) and 21 diabetic patients (age 21-78 years). Tear sampling was performed using glass capillaries and the lactoferrin concentration in tears was tested employing an enzyme-linked immunosorbent assay. Tear secretion rate was measured using standardized Halberg filter paper placed in the inferior fornix for 5 min. The lactoferrin level of normal tears showed a significant inverse correlation with age, the mean value of the 8th decade (0.81 mg/ml) constituting only about half the value of the lactoferrin level found in the 3rd decade (1.48 mg/ml). The tear secretion rate also displayed a significant decrease with age, but no correlation could be demonstrated between the tear secretion rate and lactoferrin concentration. No difference was found in lactoferrin level between men and women. We were not able to demonstrate any correlation between lactoferrin content of tears and the duration of diabetes in the 21 diabetic subjects, and there was no difference between the level of lactoferrin in normal tears compared to the concentration in diabetic tears. No difference was found between the tear secretion rate in normals and in diabetics.

Adolescent↗
PubMed1986

Changes in the concentration of secretory immunoglobulin A in tears during post-operative inflammation of the eye.

Twenty-five patients operated for cataract were examined for secretory immunoglobulin A (sIgA) content of tears by an enzyme-linked immunosorbent assay technique. The patients were examined before operation and throughout the post-operative period. The pre-operative level was 795 micrograms/ml, significantly dropping on the first post-operative day to 461 micrograms/ml. Thereafter the level increased to pre-operative value, and finally decreased once more to half the pre-operative level on the 12th post-operative day. The first drop in sIgA concentration is proposed to be a dilution effect by a significantly increased tear volume as determined by the Schirmer test. The reason for the second drop is up to now unexplained, but might be the result of an exhaustion of the sIgA production by the tear glands.

Cataract Extraction↗
PubMed1986

Lysozyme in tears during post-operative inflammation of the eye.

Lysozyme (ly) concentration in tears was measured the day before and the days following intracapsular cataract extraction in 25 patients. A median ly concentration of 1.30 mg/ml was found pre-operatively. On the first post-operative day a significant drop in the median ly concentration was observed (0.58 mg/ml). Thereafter a gradual rise towards pre-operative level was found at the 12th post-operative day. An inverse correlation existed between ly concentrations and Schirmer values during the observation period, and dilution thus seems to be an important cause of the post-operative drop in ly concentration. We observed an inverse relationship between ly level, and the number (%) of patients displaying bacterial colonization of the conjunctival sac 24 h later. The most frequently isolated bacteria were staphylococcus albus and diphteroids. It is proposed that the drop in ly concentration post-operatively may contribute to an increased risk of bacterial colonization of the eye post-operatively.

Adult↗
PubMed1985

Prostaglandin E2 level in tears during postoperative inflammation of the eye.

The concentration of prostaglandin E2 (PGE2) in tears was measured by a radio immuno assay technique in 25 persons before cataract extraction and during the post-operative period. In addition we studied the clinical signs of inflammation, the tear secretion rate, the content of polymorphonuclear leucocytes (PMNs) in tears, the bacteriology of the conjunctival sac and the central corneal thickness (CCT) during this period. We found pre-operative median level of PGE2 of 82 pg/ml and on the first post-operative day a significant rise in PGE2 concentration despite increased tearing. There was a tendency towards further gradual increase in PGE2 concentration until the 5th day and thereafter a decline to pre-operative level 12 days after surgery. The conjunctiva is proposed as a possible source of the PGE2 in tears. No significant correlation could be demonstrated between PGE2 levels and clinical signs of inflammation, CCT, PMN level, bacteriology or tear secretion rate.

Adult↗
PubMed1985

The concentration of lactoferrin in tears during post-operative ocular inflammation.

Tear concentration of lactoferrin (LF) was measured by an ELISA technique and followed in 25 patients undergoing cataract surgery. The pre-operative concentration of LF in tears was 773 +/- 60 micrograms/ml (+/- SE) (range: 407-1514 micrograms/ml). On the first day following surgery, there was a significant decrease in tear LF concentration to 377 +/- 45 micrograms/ml followed by a gradual return to the initial value during a post-operative observation period of twelve days. There was an inverse linear relationship between the LF concentration and the tear secretion rate measured by a modified Schirmer I test (1 min) suggesting a constant LF secretion rate by the tear glands. The contribution of LF from neutrophils to the tear fluid seems to be of minor importance. Since LF has known antibacterial and anti-inflammatory effects, our results may contribute to a further understanding of the microbial vulnerability or resistance of the eye following surgical procedures.

Adult↗
PubMed1985

Fibronectin in tears following surgical trauma to the eye.

The concentration of the high molecular glycoprotein fibronectin (FN) was measured by an enzyme-linked immunoadsorbent technique (ELISA) in tears of 25 patients before and after cataract extraction. Both native and degraded FN was measured. The median concentration of FN in tears before surgery was 0.28 mg/l (range: 0.1-3.8 mg/l) and 0.18 mg/l (range: 0.1-1.95 mg/l for degraded and native FN, respectively. The time course of the median values of both types of FN during the post-operative observation period described a biphasic curve with peaks at the second and fifth day following operation. On the twelfth day the concentration of degraded and native FN had almost reached pre-operative levels. The variation in the post-operative FN concentration proved statistically significant. The biological significance of the changes in FN level in the post-operative period is not obvious; the first peak may be explained by a spill-over from plasma, and the second peak may reflect FN production from fibroblasts in the granulation tissue of the corneoscleral cicatrix.

Adult↗
PubMed1985

Bacterial growth in the conjunctival sac and the local defense of the outer eye.

25 patients admitted for cataract surgery were subjected to conjunctival bacterial culturings preoperatively and during the postoperative observation period. Simultaneously lactoferrin (LF), lysozyme (LY) and secretory immunoglobulin A (s-IgA) were measured in tears. The preoperative flora disclosed the growth of Staphylococcus albus (SA) and diphtheroids. Other species were only sporadically present. There was a significant rise in number of patients affected by SA and diphtheroids postoperatively (from 60 to 80%), whereas other bacteria were not present to any significant extent. LF, LY and s-IgA concentration decreased to about 50% of the preoperative level in the early postoperative period gradually returning towards their initial concentration. Correlating an antibacterial score with bacterial score we found a significant inverse relationship between the two (P less than 0.05).

Bacteria↗
PubMed1985

Prostaglandin E2 in tears.

Prostaglandin E2 (PGE2) concentration in tears was measured before and following cataract extraction, during acute anterior uveitis and in patients with chronic conjunctival complaints. Following cataract extraction a significant increased PGE2 level in tears was observed, returning towards normal level within two weeks. In patients with acute anterior uveitis low levels of PGE2 was found in tears. Half of the patients with chronic conjunctival complaints exhibited high levels of PGE2. Conjunctiva is proposed as a likely source of PGE2 in tears.

Aged↗
PubMed1984

Visual evoked response and alcohol intoxication.

Twelve eye healthy test persons were followed for 2 h after alcohol intake by frequent recordings of visually evoked pattern responses (VER's) and simultaneous determinations of the blood alcohol concentrations. VER's were recorded with a stimulus of 14' and 110' check size, and for both check sizes steady state (15 shifts per sec) and transient responses (2 shifts per sec) were analyzed. In the transient responses we found a general increase in latencies after alcohol intake, but only in one stimulus modality (2 shifts per sec, 14' check size) was the deviation statistically significant. The steady state responses showed a large pre-alcoholic variability both in amplitudes and in latencies. No change was discernible after alcohol intake. No correlation was found between the various levels of alcohol concentration and any of the VER parameters. The minor changes of the VER found in this study using a patterned stimulus are discussed and compared to the findings in earlier studies using a flash as well as a patterned stimulus.

Adult↗
PubMed1982

Pterygium, the dominant eye and the habit of closing one eye in sunlight.

Based on findings in 21 patients with pterygium and 22 normal controls a theory is proposed that pterygium develops initially in the dominant eye. In 13 patients with unilateral pterygium the disorder in 13 was located in the dominant eye. The visual response to intense sunlight of the 21 control subjects confirmed the clinical observation that the non-dominant eye is closed and the dominant eye held open in people facing the sun. These results might explain why pterygium usually occurs first in the dominant eye. A genetic pre-disposition for the disorder is likely.

Adult↗