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Biomedical subjects

O Löw

Publications and source records attributed to O Löw.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Testicular biopsies in male diabetics].

Histological exazerbations in 17 diabetics who underwent a biopsy of the testicles and 6 control persons with healthy metabolism could increasedly prove findings deviating from the normal in male diabetics. Disturbances of the germinal epithelium of slight to middle degree are in the foreground, which must not be overvaluated in their effect on fertility. In the relatively frequent childlessness in the marriages of diabetic males disturbances of the potentia coeundi apparently play an important role.

Adult↗
PubMed1980

Effects of levonorgestrel and STS 557 on testis in rodents.

In immature male Wistar rats levonorgestrel and STS 557 (17 alpha-cyanomethyl-17 beta-hydroxyestra-4,9(10)-diene-3-one) reduced testicular growth, testicular DNA contents and plane of tubular cross-section in a dose dependent manner. In this respect, STS was less active than levonorgestrel. In immature castrated male rats the LH-suppressing effect of STS 557 was about 15 times lower than that of levonorgestrel. The results suggested that peripheral inhibitory effect of the two progestins was coupled with central LH suppression. On the other hand, in mating tests with male hybrid mice STS 557 possessed high fertility inhibiting activities in comparison to levonorgestrel and chlormadinone acetate. Limited dissociation has been shown between fertility inhibition and mating rate. All changes were reversible. Findings are discussed in view of development of male contraceptives.

Animals↗
PubMed1980

[Morphometrics of the thyroid gland].

The structural parameters of the thyroid gland are not in all cases homogeneously distributed in the whole organ. So it is possible, that the ratio colloid: epithelium may be very different. In such cases it is favourable to measure stage-wise cut specimens in constant distances. By this the differences, caused by the inhomogeneous distribution, were compensated for. The degree of such differences is demonstrated by a measuring example and a model for calculation.

Colloids↗
PubMed1980

[Quantitative structural studies on the testes].

Structural elements of testis are relatively homogenously distributed, though there are marked individual differences. No greater variations in the mean values of the tubular diameters in different sectional planes were found. It was studied, how the mean values are changed by growing number of dates, e.g. for the nuclear volumes of the Leydig cells and the tubular diameters. Testing the antigonadotropic activity of steroids both these structural parameters follow the changes in the organ weights, partially with reduced sensitivity. From quantitative data of testis structure conclusions can be drawn for biological processes.

Humans↗
PubMed1979

Studies on the quantification of local tissue injury following intramuscular injection of aqueous solutions. VIII. The local lesion after application of turimycin in different preparations.

The increase in drug concentration in aqueous solutions is not responded to by a comparable enlargement of volume of necrosis after intramuscular injection. After application of TURIMYCIN the lesion is more voluminous than those caused by penicillin, lower than those following OTESOLUT and nearly equal to those caused by 5% WOFAPYRIN (phenylbutazone + aminophenazone 1:1).

Animals↗
PubMed1979

Morphometric investigations on endocrine glands. V. Changes in the testes of Wistar rats after application of chlormadinone acetate and norethisterone acetate.

In growth inhibiting tests of rat testes the tubular diameter and, somewhat less sensitive, the nuclear volume of the Leydig cell follow the weight changes. Chlormadinone acetate shows antigonadotropic activity only at high doses and a dose-dependent antiandrogenic activity. The dose-weight curve under norethisterone acetate has a minimum at 4.2 mg/rat/14 days; higher doses seem to be accompanied by androgenic efficiency.

Animals↗
PubMed1978

Morphometric investigations on endocrine glands. IV. The rat thyroid during liver regeneration after partial hepatectomy with and without application of carcinogenic substances.

Morphometric studies and counting of mitoses in thyroids during regeneration after partial hepatectomy had the following results: 1. During the first days after surgical operation laparotomy caused only a slight reduction of the thyroid function. 2. Up to the 3rd day and especially on the 10th day after partial hepatectomy there is a higher relative percentage of the epithelium in the thyroid, but the mitoses are diminished. 3. Prefeeding with methylnitrosourea and acetylaminofluorene before the surgical 2/3 removal of the liver was answered with subactive thyroids on the 3rd day.

2-Acetylaminofluorene↗
PubMed1975

[Effects of Turisynchron and Suisynchron on the thyroid gland in rats during simultaneous administration of TSH].

Thyrotrophin was injected i/p at 2 I.U. daily simultaneously with oral administration of Turisynchron at 100 mg/kg or Suisynchron at 125 mg/kg daily for five days to Wistar rats. The uptake of radio-iodine by the thyroid was reduced, and there were slight changes in thyroid structure. Suisynchron produced a milder inhibition of thyroid regulatory mechanisms than Turisynchron.

Animals↗
PubMed1974

[Morphometry of endocrine organs. 2. Karyometry of dog and swine thyroid glands following administration of TURISYNCHRON and SUISYNCHRON].

Administration of TURISYNCHRON (metallibure) to dogs at 1 mg/kg/day for six months did not affect the histological structure of the thyroid, but the volume of nuclei of thyroid epithelial cells was reduced by one-third. In pigs given 100 mg/animal daily for 100 days, this nuclear contraction amounted to only 11%. Metallibure zinc complex (TURISYNCHRON-Z, SUISYNCHRON) given at 1 and 10 mg/kg/day for six months had a similar action on the thyroid.

Animals↗