Lack of effect of diet on the pharmacokinetics of enrofloxacin in horses.
Explore the source record for details and available documents.
Administration, Oral↗
Biomedical subjects
O Levi
Publications and source records attributed to O Levi.
Seroprevalence of Anaplasma phagocytophilum among healthy dogs and horses in Israel.
The presence of reacting antibodies to Anaplasma phagocytophilum has previously been demonstrated in Israel, both in humans and the golden jackal (Canis aureus syriacus). This study was undertaken to determine the seroprevalence of A. phagocytophilum antibodies in two additional potential hosts, domestic dogs and horses in order to investigate the possibility of exposure to the organism in Israel. Of 195 dogs tested, 9% were seroreactive with A. phagocytophilum antigen and 30% were seroreactive to Ehrlichia canis. Twenty-nine percent of the dogs seropositive for E. canis were also reactive to A. phagocytophilum. Two dogs had immunofluorescence antibody (IFA) antibody titres for A. phagocytophilum greater than E. canis. The equine serological survey (n = 300) revealed no seroreactive horses. The results presented in this study suggest that dogs in Israel could have been accidentally exposed to A. phagocytophilum, for example by ticks carried on migrating birds, however, the possibility of cross-reaction with E. canis should also be considered. In spite of the high prevalence of ticks on horses in Israel during the summer months, no evidence for exposure to A. phagocytophilum was apparent.
Anaplasma phagocytophilum↗
Optical parametric oscillation in quasi-phase-matched GaAs.
We demonstrate an optical parametric oscillator (OPO) based on GaAs. The OPO utilizes an all-epitaxially-grown orientation-patterned GaAs crystal that is 0.5 mm thick, 5 mm wide, and 11 mm long, with a domain reversal period of 61.2 microm. Tuning either the near-IR pump wavelength between 1.8 and 2 microm or the temperature of the GaAs crystal allows the mid-IR output to be tuned between 2.28 and 9.14 microm, which is limited only by the spectral range of the OPO mirrors. The pump threshold of the singly resonant OPO is 16 microJ for the 6-ns pump pulses, and the photon conversion slope efficiency reaches 54%. We also show experimentally the possibility of pump-polarization-independent frequency conversion in GaAs.
Journal Article↗
High insulin requirements and poor metabolic control do not modify the expression, regulation and PKC mediated activation of the p21ras pathway in PBMC from type II diabetic patients.
AIMS: To asses whether clinically severe insulin resistance and poor metabolic control in patients with type 11 diabetes are associated with aberrant expression or function of the p21ras pathway. METHODS: We examined the expression and function of the p21ras pathway in resting and activated PBMC from 10 insulin treated patients with type II diabetes characterized by high insulin requirements and poor metabolic control (IR group) and 10 age and sex matched well controlled patients treated by diet alone or oral hypoglycemic medications (WC group). RESULTS: Levels of p21ras and its regulatory elements: p21rasGAP and hSOS1, were comparable in the two groups. The induced activities of p21ras and its associated down-stream regulatory enzyme MAP-kinase following TPA stimulation were also comparable in the IR and WC patients. CONCLUSIONS: Taken together, these data indicate that clinically significant severe insulin resistance does not modify the expression, regulation and activation of p21ras pathway in PBMC of patients with type II diabetes.
Aged↗
Defective activation of p21ras in peripheral blood mononuclear cells from patients with insulin dependent diabetes mellitus.
We previously reported that a decreased TCR mediated activity of the GTP-GDP binding p21ras protooncogene is associated with prediabetes in non-obese diabetic (NOD) mice. Furthermore, prevention of autoimmune diabetes is associated with reversal of the p21ras signaling defect in NOD T cells. Based on these animal studies we determined the activation of p21ras in PBMC from patients with Insulin Dependent Diabetes Mellitus (IDDM), Non-Insulin Dependent Diabetes Mellitus (NIDDM) and normal healthy controls. Stimulation by PHA induced a decrease of 3.7 +/- 1.4% and an increase of 2.44 +/- 2.3%, p < 0.02 and 2.6 +/- 1.6%,p < 0.003 in the basal unstimulated p21ras activity in the IDDM, NIDDM and normal control groups, respectively. Expression of p21ras and its regulatory elements, the GTPase activating protein p120ras-GAP and the guanine nucleotide releasing factor (GNRF) hSOS, was comparable in the three groups. The in vitro proliferative response to PHA was comparable in the IDDM and control groups: stimulation index (SI) of 8.6 +/- 2.5 and 9.4 +/- 3.5 respectively, p < 0.44. No correlations were found in the IDDM patients between the degree of p21ras activation and the mitogen induced in vitro proliferative response or the various clinical parameters including age, gender, disease duration, daily insulin requirements and metabolic control. Taken together these data indicate that PBMC from IDDM patients are characterized by a persistent impairment in the activation of their p21ras. They also suggest that p21ras stimulated activity is a sensitive and independent parameter of PBMC activation in these patients.
Adolescent↗
Development of latent fingerprints using a corona discharge.
A novel technique for the development of latent fingerprints is presented. It is based on placing a fingerprint-bearing object inside a corona discharge induced plasma. The development of various real and artificial fingerprints on metallic substrates under a wide range of conditions is studied. Using the results of the development experiments and the results of X-ray photoelectron spectroscopy, it is shown that the development is based on oxidation of the fingerprint background. This is achieved by strong oxidizers generated by the discharge process, while saturated fatty-acids found in sebaceous fingerprints protect the area beneath them, resulting in a visible fingerprint. The process is optimized by minimizing the electrode gap distance and maximizing the peak discharge voltage and the pulse repetition frequency.
Dermatoglyphics↗
Protooncogenes and autoimmunity.
Explore the source record for details and available documents.
Animals↗
Myocarditis following envenoming with Vipera palaestinae in two horses.
Cardiac disease developed several days to weeks after resolution of local inflammation caused by envenoming by Vipera palaestinae in two horses. In one horse (case A), referred to the hospital for recurrent abdominal pain 8 days after envenoming, a tachyarrhythmia was detected; ventricular premature depolarizations were diagnosed by ECG. A second horse (case B) was found dead without premonitory signs 60 days after envenoming. In both horses, there was extensive necrosis of cardiac ventricular tissues.
Animals↗
[Women entering medicine: implications for health care in Israel].
An increasing number of women have been entering the medical profession during the past 2 decades. In all 4 medical schools in Israel, 46% of the students in 1989 were women, as were 30% of hospital residents. However, only a few women have reached top academic posts. With the increasing growth of immigration from the Soviet Union, a further increase in the number of women physicians is expected. However, half of the hospital-based residents of both sexes have similar specialty paths in pediatrics and medicine, but there are significant differences with regard to the other specialties: more men choose hospital-based surgical specialties, while women usually enter family medicine and psychiatry, mostly in an out-patient setting. These findings are compatible with other studies in Israel and abroad which reflect women's greater compassion and ability to communicate with patients and their families, as compared to men. Male physicians are more competitive and tend to seek professional status, power and practical rewards. It is anticipated that these trends will influence the nature and the education of the medical profession in the direction of a more humane type of medicine.
Career Choice↗