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Biomedical subjects

O Lindfors

Publications and source records attributed to O Lindfors.

47 records · Page 3Linked to original sources
PubMedDate not supplied

The effect of acetylsalicylic acid on the outcome after lower limb arterial surgery with special reference to cigarette smoking.

A prospective controlled study of 144 patients with peripheral obstructive arterial disease was undertaken to evaluate the efficacy of acetylsalicylic acid (ASA) treatment (250 mg daily) on the outcome after lower limb arterial surgery which mainly involved endarterectomy. By random enrollment, 2 groups of 72 patients were formed after the surgery. Patients with ASA treatment for 3 months, starting from the seventh postoperative day, were compared with patients who were not treated with ASA. The patients in both groups had similar characteristics as to sex ratio, age, concomitant diseases, preoperative arm-ankle systolic blood pressure index, and type and primary success of the reconstruction. Forty-seven of the ASA-treated and 48 of the untreated patients reported to continue cigarette smoking. Postoperative ASA-treatment protected against local adverse events which occurred in 15 patients (21%) of the ASA-treated group compared with 31 patients (43%) of the untreated group (p less than 0.01). Among heavy smokers (greater than 15 cigarettes/day) the efficacy of antiplatelet treatment was not detectable. These results imply that, in patients with peripheral arterial disease, ASA prevents platelet interaction to endarterectomized and atherosclerotic lower limb arteries thereby affecting the subsequent risk of occlusion; however, heavy cigarette smoking, which is very common among patients with peripheral arterial disease, counteracts the local antithrombotic potency of ASA.

Adult↗
PubMedDate not supplied

Microangiography of rejected human kidney transplants.

A microangiographic study of 17 rejected and surgically removed human kidney transplants, three transplants removed for other reasons and two adequately perfused and preserved but not transplanted cadaver kidneys was performed. Transplants rejected with acute clinical course showed poor or variable glomerular filling and tapering cortical arteries with no impairment of medullary perfusion, more extensively in those transplants showing poor initial function. Chronic rejection, independent of other parameters showed lack of cortical perfusion, and glomerular filling; impaired perfusion of whole segments, arterial wall narrowing and changes secondary to kidney shrinkage. The radiographic patterns of chronic and acute rejection were distinguishable from each other and from nonrejected specimens.

Angiography↗
PubMedDate not supplied

Experience with different types of fistulas and shunts for hemodialysis.

Three alternative methods to obtain access to the circulatory system for hemodialysis has been used. The Cimono-Brescia fistula is the method of choice and is almost always successful if the vessels are intact. The femoral Quinton-Scribner shunt has proved unreliable and dangerous. The subdermal vein graft is a useful and acceptable alternative if the vessels of the upper limbs have been destroyed.

Arteriovenous Anastomosis↗