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Biomedical subjects

O Linna

Publications and source records attributed to O Linna.

27 records · Page 2Linked to original sources
PubMed1985

A 5-year prognosis of childhood asthma.

A series of 207 asthmatic children aged 4-10 years studied during the years 1976-1978 were called for a follow-up study 4-6 years later. Of these, 53 (26%) children were completely symptom-free and 154 still had symptoms. The proportion of symptom-free patients was highest (45%) among those having attacks only during respiratory infections. The prognosis was worsened by such factors as a high rate of attacks, an association with eczema and a history of otitis media or adenoidectomy. The clinical picture of disease among children having attacks only during respiratory infections (wheezy bronchitis) was distinctive from that in asthma and may be separated as its own entity. Subgrouping of childhood asthma is beneficial for a clinician when considering the intensity of therapy or the need for controls.

Asthma↗
PubMed1983

Environmental and social influences on skin test results in children.

Skin tests with 13 inhalant allergens were performed in 788 children with respiratory allergy. Positive reactions were common to animal danders (65%), to grass pollens (55%) and to tree pollens (44%) but rare to moulds (13%) and to house dust mite (12%). Children exposed to cows, dogs or horses at home more often had skin test reactions to these allergens than the children not exposed, but reactions to cat dander occurred as frequently in children exposed to cats at home as to those not exposed. Reactions to three pollens occurred most often in children from upper social classes and from urban areas and reactions to house dust mite occurred most often in children from lower social classes and from rural areas. Children with positive reactions to house dust mite came from larger families than children with negative test results.

Adolescent↗
PubMed1982

Close contact with tuberculosis in childhood.

In a 1-year prospective study 83 children, who had been in close contact with 52 adults who had tuberculosis, were examined. Thirty-six of the index cases had culture positive tuberculosis and 16 of these had smear positive tuberculosis. All the children had been BCG-vaccinated at birth. Forty-one (49%) of the children were PPD negative on examination with the Mantoux test. Of these 83 children, one 14-year-old boy was diagnosed as having primary tuberculosis and was treated. Twenty-one children received INH therapy, 12 because of their age (under 2 years of age or at puberty), nine because of a strong positive reaction to the first Mantoux test or because of the conversion of a negative test result to positive during the follow-up period. Seven of the latter nine children had been in contact with persons whose disease was culture- and smear-positive. It is concluded that as the frequency of tuberculosis declines, the practice of examining all children who have been in close contact with tuberculous adults is possible. The children who have been in contact with smear-positive index cases are at special risk of contracting tuberculosis.

Adolescent↗
PubMed1981

Chronic lung damage caused by adenovirus type 7: a ten-year follow-up study.

Twenty-seven children aged 0.6 to 7.0 (mean 2.1) years were admitted to the hospital in 1967 and 1968 with type 7 adenoviral pneumonia. All ran a prolonged course. Type 7 adenovirus was isolated from 14 children, and in the other 13, the rise in the titer of complement-fixing antibodies to adenovirus was fourfold or greater. The outcome of the disease in these 27 children was reassessed in 1979, 9.6 to 12.1 (mean 10.7) years after the adenovirus type 7 pneumonia. Twenty-two were examined clinically and roentgenographically and all had lung function tests. Twelve had abnormal chest roentgenograms, and of these, six had bronchiectasis. Six of the ten children with normal chest x-ray films and ten of the 12 with abnormal chest roentgenograms had abnormal pulmonary function tests. Of the six patients with bronchiectasis, four showed no discernible cause of bronchiectasis other than the antecedent type 7 adenoviral infection. The other two patients had bronchial asthma, which can be a risk factor for bronchiectasis.

Acute Disease↗
PubMed1980

Hepatotoxicity of rifampicin and isoniazid in children treated for tuberculosis.

In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maximal ASAT values between 40 and 100 U/L were treated without any changes in the regimen and the transaminases normalized later in the treatment. Six out of the eight children with ASAT values over 100 U/L were allowed a three-week pause in their therapy, one was given the same dose of rifampicin, and in one the treatment was discontinued entirely. The therapy was discontinued in an additional three children because of a second high rise in the transaminase values. Liver injury can occur at any time during treatment, and thus makes continuous follow-up tests necessary.

Adolescent↗
PubMedDate not supplied

Influence of baseline lung function on exercise-induced response in childhood asthma.

The dependence of bronchial reactivity to exercise on baseline lung function was studied in 84 asthmatic children aged 7-16 years. The percentage fall in PEF values after a standard exercise running test was 8.4 +/- 8.6% in the 39 children with an attack rate of less than 10 per year and 29.6 +/- 23.2% in the 45 children with an attack rate of 10 or more per year (p less than 0.001). A significant negative correlation (r = -0.46, p less than 0.001) was found for pre-exercise MMEF and other sensitive tests of airway calibre with the response to exercise, but no such correlation was found between baseline PEF or SGaw values and the exercise response. These results show that bronchial hyperreactivity to exercise is dependent on residual airway obstruction, but a wide variety of reactivity can occur. If the baseline flow-values are less than three standard deviations below the mean reference, however, a clinically significant response to exercise can be predicted.

Adolescent↗