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Biomedical subjects

O M Karpenko

Publications and source records attributed to O M Karpenko.

13 recordsLinked to original sources
PubMed1989

[Laser conization in the treatment of early forms of cervical cancer].

High laser excision has been used as an organ-sparing method for early cervical cancer in 30 patients, admitted to the P. A. Herzen Gynecological Clinic. Mean age of the patients was 35.7 +/- 1.5 years. The stage of the disease corresponded to intraepithelial cancer in 15 patients, and to micro-invasive cancer in another 15. The patients were followed-up for 6 months to 2 years, there were no relapses or menstrual disorders. Complications included early postoperative bleedings in 4 patients (the operation was performed in the premenstrual days).

Adult↗
PubMedDate not supplied

[Quantitative changes in characteristics of immunity in longlivers].

In 93 persons aged 90 to 103 years old the subpopulation compositon of lymphocytes and the level of thymic serum activity (TSA) was studied. In the presence of polymorbidity the low level of TSA was observed in 81% of examinees, with the quantitative deficiency in the relative and absolute number of CD3+CD8+ T-lymphocytes (62% and 78% respectively) and the excess in the number CD3+CD4-CD8- T-lymphocytes (42% and 57% respectively). Among CD3+CD4-CD8- T-lymphocytes cells with phenotypes CD3+/-CD4-CD8-CD16- and CD3+CD4-CD16+ were determined. In prolonged imunomonitoring the reciprocacity of changes in the amount of CD3+/-CD4-CD8-CD16- T-lymphocytes was established in relation to the level of TCA and the number of CD3+CD8+ T-lymphocytes. The reversibility of these changes is indicative of the potential of reactivity of the immune system in longlivers. The positive result of laser therapy in persons with quantitative deficiency of CD3+CD8+ T-lymphocytes and the presence of cells with phenotype CD3+/-CD4-CD8-CD16- was associated with the restoration of the size of CD3+CD8+ subpopulation and a decrease in an amount of CD3+/-CD4-CD8-CD16-. The unfavorable prognostic sign was, seemingly, the quantitative deficiency of CD3+CD8+ T-lymphocytes with the low level of TCA in the absence of CD3+/-CD4-CD8-CD16- T-lymphocytes.

Aged, 80 and over↗
PubMedDate not supplied

[Instrumental methods in diagnosing and treating cancer patients in the polyclinic].

In a general program of the anticancerogenic therapy several aspects should be now emphasized. Among them, apart from such problems as the organization of anticancerogenic therapy by skilled professionals and prophylactic medical examinations of oncologic patients including the provision of clinical, occupational and social rehabilitation, the early detection of malignant tumors at the beginning morphologic stages is of a great importance. It is noted that a number of measures permits avoiding serious and complex therapy. These are the detection of "high risk" groups, complex clinical examinations using state-of-the-art diagnosis methods including mammography, ductography, thermography, puncture biopsy followed cytologic studies, histologic studies of tissues ablated in the course of partial mammectomy as well as in the laser dissection of skin pigment formations performed in ambulatory conditions.

Academies and Institutes↗