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Biomedical subjects

O M Lilien

Publications and source records attributed to O M Lilien.

At least 19 recordsLinked to original sources
PubMed1986

Commentary and critique of Maurice Camey's enterocystoplasty.

The search for a means to create a functioning, continent urinary bladder following cystoprostatectomy is more than a century old. The Camey enterocystoplasty offers an effective solution. The evolution of this technique is reviewed and the surgical technique described.

Combined Modality Therapy↗
PubMed1981

Transcutaneous electrical nerve stimulator for stress incontinence.

It has been shown that some patients with stress incontinence after prostatectomy may have significant improvement with electrical anal stimulation. The use of a transcutaneous stimulator is the easiest and least invasive method to try initially. Results may be quite satisfying whether the mechanism is physiologic or placebo. This is the first report of the use of transcutaneous electrical nerve stimulation in patients with stress incontinence.

Aged↗
PubMed1981

Combined alizarin red-reticulum stain for tissue localization of calcium deposits.

A method combining alizarin red and a modified silver stain for reticulum fibers in tissue sections is described. The method allows precise localization of calcium deposits and crystals in relation to epithelial and interstitial connective tissue elements. The deposits and their spatial relationships are clearly discernible by light microscopy, especially with polarization. The method is particularly useful for investigating calculogenesis and may prove to be of value in the study of the mechanism and evolution of pathologic calcification in various organs.

Animals↗
PubMed1981

The microgenesis of some renal calculi.

We studied calcium oxalate stone formation in rats in which calculogenesis was induced by a diet deficient in pyridoxine (vitamin B6). We studied the sequence of stone formation using both a gross specimen transillumination technique, which is described, and histologic methods. A characteristic regional distribution of calculi is described and illustrated. Histologic studies reveal the interstitial site of calcium oxalate microlith formation. The progressive movement of these crystals through the tubular wall into the tubular lumen is described and illustrated. The formation of Randall's plaques is described and illustrated, as is a characteristic "geode" formation in the calyceal fornix. The significance of these findings is discussed and a new concept of stone formation proposed.

Animals↗
PubMed1980

Urodynamics of post-radical perineal prostatectomy incontinence.

A series of post-radical perineal prostatectomy patients was studied by carbon dioxide cystometry. Of 30 patients questioned 17 were available for urodynamic assessment. All patients had shortened functional urethral lengths and decreased maximal closure pressures and incontinent patients had changes in the standing position. A review of the pertinent literature is presented. We believe that such studies in these patients can be clinically contributory and are of academic interest but history and cystourethroscopy remain more important in the over-all patient evaluation and care. With the ever-growing enthusiasm for urodynamics it is important to reveal its limitations as well as its benefits.

Aged↗
PubMed1980

Evidence for a new mammalian organ. IV. Stone formation.

We studied calcium oxalate stone formation in rats after calculogenesis had been induced by a diet deficient in pyridoxine (vitamin B6). Urinary calculi had formed within 6 weeks in 86 per cent of 114 animals. The calcium handling properties of 17 tissues (including the renal sinus "gland") were compared in normal and pyridoxine deficient animals. A significant increase in calcium (85Sr) uptake was found in the renal sinus "gland" and the renal medulla after pyridoxine deprivation. The movement of calcium from the perihilar sinus tissues into the renal medulla was examined and the significance of our observations is discussed.

Animals↗
PubMed1978

Evidence for a new mammalian organ. II. Calcium kinetics.

The calcium content and calcium kinetics of the fatty tissue complex comprising the renal sinus organ of the rat kidney are reported. A comparison is made to control brown and white fat in the same animal. The calcium content of the renal sinus tissue is significantly greater than controls. Calcium localization in the mitochondria of the sinus tissue complex is demonstrated. Radioactive isotope studies (45Ca, 85Sr and 99mTc) indicate a dynamic exchange of calcium between the systemic pool and the sinus organ. Active accumulation appears to be operative. Supporting evidence for the existence of a portal vascular system joining the renal sinus complex and the renal parenchyma is presented. The significance of a calcium sink in the renal sinus tissue of the rat kidney is discussed.

Adipose Tissue↗
PubMed1977

Incapacitating flank pain of questionable renal origin.

Local anesthetics can play a significant role in the diagnosis, and possible definitive treatment, of previously intractable flank pain. Numerous patients may thus be spared unnecessary physical and mental anguish, as well as unnecessary surgery.

Adult↗
PubMed1977

Evidence for a new mammalian organ. II. Calcium kinetics.

The calcium content and calcium kinetics of the fatty tissue complex comprising the renal sinus organ of the rat kidney are reported. A comparison is made to control brown and white fat in the same animal. The calcium content of the renal sinus tissue is significantly greater than controls. Calcium localization in the mitochondria of the sinus tissue complex is demonstrated. Radioactive iostope studies (45Ca, 85Sr and 99mTc) indicate a dynamic exchange of calcium between the systemic pool and the sinus organ. Active accumulation appears to be operative. Supporting evidence for the existence of a portal vascular system joining the renal sinus complex and the renal parenchyma is presented. The significance of a calcium sink in the renal sinus tissue of the rat kidney is discussed.

Adipose Tissue↗
PubMed1976

Evidence for a new mammalian organ: a preliminary report.

During an investigation on the mechanisms by which mannitol increases renal blood flow, using an in vitro perfused rat kidney preparation, it was observed that an osmotic challenge (320 mOsm) was followed by the accumulation of chloride and calcium ions in the renal medulla. Although the chloride was derived from the perfusate, the source of calcium appeared to be localized in the renal sinus fatty tissue. A morphologic study of this area reveals the existence of a tissue complex, having the characteristics of a hitherto unrecognized organ or gland communicating with the renal parenchyma via a portal vascular system. The possible physiologic significance of this complex is discussed.

Adipose Tissue↗
PubMed1975

Posterior approach to the kidney.

We describe a posterior approach to surgery involving the renal pelvis or upper ureter which is quicker, more direct, and considerably less mutilating than the standard flank incision. Our five years' experience with this technique is summarized.

Adenocarcinoma↗
PubMed1975

Incidence of prostatic carcinoma in the elderly.

Published reports vary greatly in their estimation of the incidence of prostatic carcinoma. To obtain statistically valid data on the occurrence of this entity in the elderly, serial sections of the entire prostate obtained at 57 consecutive autopsies in males eighty years of age and over were analyzed. The incidence of prostatic carcinoma in this group was 66.7 per cent. The stage and grade of lesions are noted, and a correlation between specimen weight and incidence of malignancy is confirmed. Apparently disparate reports are analyzed.

Aged↗
PubMed1975

The benign killer: carcinoma of the prostate.

Radical prostatectomy has a significant role in the treatment of early stage carcinoma of the prostate, with a 6-fold difference in the radically and conservatively treated groups. Since 32 per cent of carcinomas will be missed even by experienced examiners on rectal examination, we believe that open perineal biopsy of the posterior lamella as described in 1968 would increase the yield of carcinoma and the subsequent cure by a radical operation. We have found that older patients do well with the perineal surgery--the extreme lithotomy position is no great problem and the postoperative course, without a painful abdominal wound, is less complicated.

Age Factors↗