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O M Tepelina

Publications and source records attributed to O M Tepelina.

16 recordsLinked to original sources
PubMedDate not supplied

[Effect of thymosin (fraction 5) on the development of functional activity of the adrenals and gonads in genetically athymic mice].

The paper is concerned with the effect of thymosin, a hormone secreted by the thymus (fraction 5), on the development of adrenocortical and sex gland functions in genetically athymic mice (nude mutation). Multiple administration of thymosin to mice in the 1st month of their life (0.1 microgram/mouse twice a week) caused the suppression of corticosterone production by the adrenal glands in adult mice aged 2 mos., a considerable rise of the blood level of testosterone in male mice and the reduction of the specific production of estradiol by the ovaries in females. A thymosin-mediated role in the interaction between the immune and endocrine systems in the period of development of their functions was discussed.

Adrenal Glands↗
PubMedDate not supplied

[Thymosin restoration of the interferon-synthesizing capacity of the splenocytes in mice undergoing stress exposure].

Direct correlation was established between changes in the activity of natural killers and capacity of lymphocytes for interferon synthesis after stress was demonstrated. Thymosin was found to enhance interferon synthesis in response to induction with NDV, PHA, and SEA in the period of marked inhibition of splenocyte function as a result of stress. The phenomenon of restoration by thymosin of the capacity of splenocytes in the post-stress phase to synthesize interferon in response to induction was also established in vivo.

Animals↗