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Biomedical subjects

O Maie

Publications and source records attributed to O Maie.

16 recordsLinked to original sources
PubMed1995

Giant xanthomatous dermatofibroma--a case distinguished histologically and immunohistochemically from invasive fibrohistiocytic tumors.

A 50-year-old woman presented with a skin tumor on her right calf. The tumor had been noticed 20 years previously and grew to more than 60 mm in diameter. The histological findings were characterized by numerous bland xanthomatous histiocytes and a few atypical giant cells with pyknotic nuclei, although mitotic figures were few. These findings led to the diagnosis of dermatofibroma with unusual xanthomatous expression. Immunohistochemical studies using several markers for histiocytes (lysozyme, alpha 1-antitrypsin, alpha 1-antichymotrypsin and anti-CD68 antibody), anti-factor-XIIIa antibody and anti-CD34 antibody supported the diagnosis.

Diagnosis, Differential↗
PubMed1991

[Adult dermatomyositis with angiopathy and cecum perforation].

This previously healthy 43-year-old man was admitted to our hospital with a history of rash, dysphagia and severe myalgia for two months. Physical examination showed prominent edema and erythema over the face and the chest, scattered ulcerations on the trunk, and muscle atrophy most prominent proximally. Serum levels of muscle enzymes were remarkably increased. Two weeks of oral prednisolone therapy (40 mg/day) was not effective, and betamethasone intravenous pulse therapy (3 x 1000 mg) was followed by slight clinical improvement. However, 12 days after pulse therapy, he complained abdominal pain on the right lower quadrant. The surgical findings included peritonitis due to single perforation of the cecum. After operation, cyclosporine therapy was added and over the next 14 month a considerable clinical improvement was noted. Prednisolone was reduced from 80 mg to 10 mg daily. Biopsy specimens from ulcerated+ skin and perforated cecum showed prominent vascular abnormalities: arterial and venous intimal hyperplasia, occlusion of vessels by fibrin thrombi, and lymphocytic infiltration which affected veins of all sizes. The evidence strongly suggests that both skin ulcers and cecum perforation were caused by vasculitis and occlusion of vessels, which often seen in childhood dermatomyositis.

Cecal Diseases↗
PubMed1990

[Pilomatrix carcinoma--report of the second case in Japan and a review of the literature].

A 53-year-old man had a rapidly growing tumor, measured 3 cm in diameter, on his left temporal region of 2 months' duration. The lesion showed histological resemblance to pilomatricoma but differed by the presence of irregular nests of atypical basophilic cells (basaloid cells) with focal squamoid differentiation and a large number of atypical mitoses. A review of 16 cases of pilomatrix carcinoma documented since the year of 1980 indicated that this tumor occurs in males three times more frequently than in females. 75% of all patients were over forty years old. Recurrences were seen in 6 of the 10 patients whose tumor had been resected simply, but there was no evidence of recurrence in the 4 patients with a wide resection of tumor.

Carcinoma, Squamous Cell↗
PubMed1989

DNA methylation in xeroderma pigmentosum.

DNA methylation was examined in xeroderma pigmentosum (XP) cells. The amount of 5-methylcytosine (mC) in DNA from XP cells was about 70% of that in DNA from normal controls. Southern hybridization analysis showed that the HLA-DR alpha gene in XP lymphocyte B cells was differently methylated from normals, but its expression was apparently unaffected. The methylation of dihydrofolate reductase, a housekeeping gene, was the same as in controls. The revertants to UV resistance from XP fibroblasts recovered a methylation level close to that of normal cells. Results suggested that XP DNA was undermethylated non-randomly, and that DNA methylation might be associated with DNA repair function.

5-Methylcytosine↗
PubMed1989

A case of solitary mastocytoma suggesting a divided form of mast cell nevus.

The case of a 10-week-old boy with a solitary mastocytoma is reported. The lesion, noticed at birth, was located in an area extending from the dorsum of the left hand to the proximal phalanx of the ring and little fingers. It appeared as a coin-sized, flattened dome-shaped, round tumor with occasional blistering. The web between the two fingers was free of cutaneous changes. The diagnosis was confirmed by the histological characteristics: a densely mastocytic infiltration into the dermis. The present case of solitary mastocytoma, referred to as "mast cell nevus", is unique because of its previously undescribed divided form.

Humans↗
PubMed1989

[A three-dimensional observation of human hair tissue treated by modified trypsin-HC1 method].

To observe the three-dimensional ultrastructures of human hair and hair follicle under scanning electron microscope, biopsied scalp tissues were treated by the combination of the trypsin-HC1 method and ultrasonic cleaning. After this treatment, the connective tissues surrounding the hair follicle were removed to permit the three dimensional observation of hair tissue. The following findings were obtained; 1) The basal plate, composed of fibroblasts and collagen fibers, was seen as a small disc covering the entrance of hair papilla, 2) The connective tissue (fibrous) sheet, with a capillary network, tightly surrounded the lower hair follicle. 3) A morphological difference in the cells between the cell layers constituting the hair bulb was seen; there were discoid cells in the outer and spherical cells in inner layer, 4) Numerous micro-villous projections were present on the surface of outer root sheath cells and on the surface of keratinized inner root sheath; the latter surface resembled the bark of a tree in appearance. The present modified method seems useful for three-dimensional ultrastructural observation of human hair and hair follicles.

Adolescent↗
PubMed1987

[Congenital nevus cell nevi as precursors of melanomas of the skin].

Based on our observations in 25 patients and on the literature of the last few years, we comment on the clinical findings, genetics, histology, ultrastructure, malignant degeneration and therapy of congenital nevocytic nevi. The differences between large and medium-sized nevi are emphasized.

Cell Transformation, Neoplastic↗
PubMed1986

The ultrastructure of congenital nevocytic nevi. II. Nevus cell morphology and contacts with nerve fibers.

As only few previous investigations considered size-dependent differences in the histology of congenital nevocytic nevi (CNN) or focused on their ultrastructure, a light- and electron-microscopic study of six giant and six medium-sized CNN was performed. Histologically, giant CNN showed minimal junctional nevus elements and a pandermal, diffuse nevus cell extension including the subcutaneous tissue, while medium-sized CNN exhibited more abundant junctional nests and a rather focal pattern of nevus cell extension into the reticular dermis. Ultrastructurally, giant CNN often showed nevus cells with irregular and indented nuclei and also nevus cells with highly complicated dendrites. Nuclear inclusions, multiple cilia and centrioles, and collagen phagocytosis in nevus cells were found in both groups of CNN. Direct contacts between nevus cells and nerve fibers were observed in medium-sized CNN only. The findings provided no clear morphological indication why giant CNN have a higher risk for malignant degeneration than medium-sized CNN or acquired nevocytic nevi (ANN). On the other hand, the histological differences speak in favor of a different ontogenesis of the various size classes of CNN and ANN.

Axons↗
PubMed1985

The ultrastructure of congenital nevocytic nevi. I. Nevus cells in walls of blood vessels and lymphatics.

As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in subcutaneous veins in 3 out of 8 patients with garment nevi. In all cases, the nests histologically consisted of benign-appearing subendothelial B-type cells. Ultrastructurally, the features of these nevocytes essentially corresponded to those of nevocytes in the surrounding area. In 1 patient with a garment nevus, in whom affected vessels of the lumbar area as well as of the neck were examined, the nevus-cell nests were exclusively situated between the endothelium and its basal lamina. These nevocytes appeared to be more electron dense, but had no unequivocally atypical features. In the region of these nests, the endothelium was often discontinuous; thus, the nevus-cells were in direct contact with the lumen. Some of these cells exhibited slight degenerative changes. The lymphatics were affected in 6 of the 18 cases of garment nevi and in 2 of the 11 cases of medium-sized nevi. The morphological findings were comparable to those for blood vessels. It is concluded that, in garment nevi, morphologically benign nevocytes may be carried off hematogenously as well as lymphogenously.

Blood Vessels↗
PubMed1981

[Local thermotherapy in sporotrichosis].

Two patients with sporotrichosis, one of the cutaneous-lymphatic type, the other of the fixed cutaneous type, were treated with local heat therapy. The "pocket warmer" used for this purpose has the advantage of being able to maintain a constant temperature of 44 degrees-45 degrees C on the skin surface for several hours, while permitting unrestricted freedom of movement. There are no side effects. The duration of treatment depends on the type of lesion, location, depth, and size. Generally, local application for 1-2 h per day for 5-6 weeks seems to be sufficient.

Aged↗
PubMed1981

[Cutaneous chromomycosis: therapy with intra-lesional amphotericin B injections].

Three different types of cutaneous chromomycosis, verrucous tumor type, eroded granuloma type and scaly erythematous plaque type, are reported. All these cases were successfully treated with intralesional injections of procaine-amphotericin B solution. This treatment for cutaneous chromomycosis seems to be favorable because of evident clinical efficiency without severe local or systemic side effects.

Administration, Topical↗
PubMed1976

Xanthoma secondary to reticulo-histiocyte infiltration.

Three cases of xanthomas occurring secondarily are reported: The primary dermatoses were erythroderma, actinic reticuloid and histiocytosis X. Although a slight elevation of pre-beta-lipoprotein was recognized, xanthomas occurring in these particular 3 cases were assumed to be due to the proliferation or hyperplasia of reticulohistiocytes in the skin. The foam cells found in the xanthoma case with erythroderma and actinic reticuloid appeared different from those with histiocytosis X in their fine structures. The lipid constituents of the xanthoma lesion were found to be quite dissimilar from those of serum lipids.

Aged↗
PubMedDate not supplied

Localized cutaneous cryptococcosis successfully treated with itraconazole. Review of medication in 18 cases reported in Japan.

A case of localized cutaneous cryptococcosis successfully treated with oral itraconazole is reported. The patient, a 63-year-old Japanese housewife, had had an erythematous and partly eroded lesion in the area of her right earlobe for about 10 months. No findings suggesting a primary focus of Cryptococcus infection were found in the lung, central nervous system or other internal organs. The isolate obtained from the lesion was identified as Cryptococcus neoformans based on the demonstration of encapsulated blastospores and its biological characteristics. The clinical course shifted toward healing in parallel with a decreased serum level of anticryptococcal antibody after initiation of treatment with oral itraconazole in a dose of 100 mg once daily. The treatment was discontinued after 13 weeks. There were neither subjective nor objective side effects. Furthermore, this paper reviews the medications employed in 18 cases with cutaneous cryptococcosis reported in Japan during the nearly 40-year period between 1952 and 1989.

Administration, Oral↗