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O Maleci

Publications and source records attributed to O Maleci.

6 recordsLinked to original sources
PubMed1978

The possibility of identification of oligodendrocyte-myelin sheath processes in the white matter of rats.

When myelination is completed it is no longer possible to see with the EM the continuity of myelin sheath with the oligodendroglial processes. An ultrastructural study has been therefore carried out of the unmyelinated of the white matter to see whether it might be possible to recognize the presence of such continuity. The following were considered: 1) unmyelinated fibres in bundles, 2) astroglial processes, 3) large oligodendroglial processes, 4) tongues, 5) "fibre-like" processes (including tubulus and filamentes which are partly identifiable as either unmyelinated fibres or thin oligondendroglial processes). In addition to morphology, quantitative aspects were also considered such as area of section of each process and number of tubules and filamentes present in each section. No substantial quantitative differences were found between "fibre-like" processes and unmyelinated fibres in bundles. These findings failed to show any morphological evidence of connections between myelin sheaths and oligodendroglial processes. This however still possible that the oligodendroglial processes are so few in number in comparison with the unmyelinated fibers that their statistical contribution is negligeable and that no substantial error is made in identifying all "fibre-like" processes as unmyelinated fibres.

Animals↗
PubMed1977

[Clinical and pathological observations on a case of granulomatous encephalitis (probable criptococcal infection) (author's transl)].

A case of granulomatous encephalitis in a 42 year old woman is reported. During the course of her illness, she showed over a short period of time a left hemiparesis, epileptic seizures and severe impairment of consciousness. Bilateral carotic angiography showed no evidence of an expansive lesion, while brain-scan presented an hyperactive area in the right parasagittal region. The cerebrospinal fluid examination demonstrated an increasing hyperproteinosis and death occurred 45 days after the first symptoms appeared. At post mortem in addition to brain edema, a soft, grey-brown discoloured area, of the size of hazel nut was found in the right limbic convolution. Histologically the abnormal tissue revealed a granulomatous structure formed by thick masses of lymphocytes, plasmacells and epithelioid cells among which vessel neoformation and hemorrhages were noted. Remarkable perivascular infiltrations were seen in the white matter, in the gray matter and in the leptomeninges also far away from the granulomatous focus. Many round yeast-like elements were observed free in the tissue as well as inglobated in large histiocytes. Although morphologically they resembled Cryptococcus neoformans organisms, the specific staining techniques for the mycoses were negative. The authors, after reviewing the various histopathological pictures of cryptococcosis in the nervous system and the modern diagnostic procedures for this mycotic infection during life, discuss the range of so-called primitive granulomatous encephalites.

Adult↗
PubMedDate not supplied

[Subacute sclerosing panencephalitis in adults. Anatomo-clinical illustration in 1 case].

A 23 years old man suffering from SSPE died 18 months after the onset of the disease. The clinical picture, EEG and immunological tests were typical for SSPE, and so was the anatomo-pathological investigation; the only difference was that the Cowdry type A inclusion bodies were absent. The peculiarity of this case consists in the fact that the disease appeared in an adult. In the literature we found very few cases of SSPE with such a late onset.

Adult↗