Biomedical subjects

O Manor

Publications and source records attributed to O Manor.

At least 19 recordsLinked to original sources

PubMed2005

Does one's own and one's spouse's education affect overall and cause-specific mortality in the elderly?

OBJECTIVES: To examine educational gradients in overall and cause-specific mortality among elderly married men and women and their spouses. METHODS: Using the census-based Israel Longitudinal Mortality Study (1983-92), 13 573 married men and 6563 married women were identified who were aged 70-89 years at baseline. Cox proportional hazard models were used to assess the strength of the association between education and overall and cause-specific mortality. RESULTS: Educational gradients for own and spouse's mortality varied by gender and cause of death. In particular, in relation to cardiovascular disease, men married to uneducated wives experienced elevated mortality risks [hazard ratio (HR) = 1.30; 95% confidence interval (95% CI) 1.11-1.52]. Women were generally unaffected by their husband's education, except for those who died from non-breast cancer, for whom husband's low education had a harmful effect (HR = 1.98; 95% CI 1.26-3.11). CONCLUSIONS: Mortality among elderly married persons is associated with one's own and one's spouse's educational achievement. Research using partner's education as a proxy for one's own attainment may be omitting valuable information regarding these and other health risks.

Aged↗

PubMed2005

Paula method of circular muscle exercises for urinary stress incontinence--a clinical trial.

The aim of this study was to determine the efficacy of the Paula method of circular muscle training in the management of stress incontinence (SI). The theory behind this method states that activity of distant sphincters affects other muscles. In a pilot study, 59 women, mainly hospital employees, were randomly assigned to participate in exercises according to the Paula method or pelvic floor training. Efficacy was measured by reports of incontinence, quality of life (I-QOL), pad test, and pelvic floor muscle strength (assessed by perineometer and digital examination). Both the Paula exercises and pelvic floor training produced significant changes in urinary leakage compared to baseline as measured by the pad test [mean decrease of 5.4 g (p=0.002) and 9.5 g (p=0.003), respectively]. Women randomized to the Paula method reported improvement in I-QOL scores. The Paula method was found to be efficacious for SI in a population of Israeli women. Larger community-based studies will be required to confirm these results and enable evaluation of between-group differences.

Adult↗

PubMed2005

Changes in diet and physical activity in the 1990s in a large British sample (1958 birth cohort).

OBJECTIVES: To investigate whether adults studied in 1991 and 1999 (at ages 33 and 42 y) improved their diet and their physical activity level, in the direction of recommendations issued during the same period. DESIGN: Longitudinal 1958 British birth cohort study. SETTING: England, Scotland and Wales. PARTICIPANTS: All births, 3rd-9th March, 1958. A minimum of 11 341 participants provided data at 33 y, 11 361 at 42 y. MAIN OUTCOME MEASURES: Frequency of leisure time activity and consumption of (i) fried food, (ii) chips, (iii) wholemeal bread and (iv) fruit and salad/raw vegetables, at 33 and 42 y. RESULTS: Most people changed their physical activity and dietary habits over the 8-y period. About a third of men and women increased, and a third decreased their activity frequency. Findings for fried food consumption were similar. A significantly greater proportion of cohort members decreased their chips consumption (32%), rather than increased it (17%) and increased their fruit and salad consumption (30%), rather than decreased it (25%). In all, 26% of men and 33% of women consistently ate, or switched to eating mostly wholemeal bread, while 56% of men and 48% of women consistently ate less or switched to eating less. Social gradients were seen for activity and diet in 1991, but associations between social factors or body mass index and change in activity or diet were inconsistent. CONCLUSIONS: Lifestyle habits such as dietary intake and physical activity are slow to change. Current health promotion strategies may need to be supplemented with additional methods to affect the desired change in these habits.

Adult↗

PubMed2005

Physical activity, television viewing and body mass index: a cross-sectional analysis from childhood to adulthood in the 1958 British cohort.

OBJECTIVE: To investigate relationships between frequency of physical activity or television viewing and body mass index (BMI) cross-sectionally at six ages from childhood to adulthood, to better understand longitudinal relationships. To investigate how the relationships vary with age and gender and whether any relationships are due to confounding factors. METHODS: The 1958 British birth cohort includes all births (approximately 17 000) in one week in March 1958. BMI and physical activity frequency were recorded at 11, 16, 23, 33 and 42 y and television viewing frequency at 11, 16 and 23 y. A total of 11 109 subjects provided BMI and activity data at 42 y. Relationships between BMI and (in)activity were investigated using linear regression. RESULTS: At ages 11, 33 and 42 y in both sexes and at 23 y in female subjects, those who were more active had lower BMIs, and the relationships strengthened with age. At 42 y, the most active had a lower mean BMI than the least active, by 0.83 kg/m2 in men, and 1.03 kg/m2 in women. BMI and activity were unrelated at 16 y in female subjects, and 23 y in male subjects. At 16 y in males, the most active males had a mean BMI 0.25 kg/m2 higher than the least active. At 11 y in female subjects and 23 y in both sexes, those who watched television most frequently had higher BMIs. BMI and television viewing were unrelated at 11 y in males and at 16 y in both sexes. Relationships between BMI and activity or television viewing were largely unexplained by potential confounding factors. CONCLUSIONS: The relationship between BMI and physical activity changes with age. In early adolescence and in adulthood, a higher activity level, or lower frequency of television viewing was associated with a lower BMI. In later adolescence (16 y), television viewing and activity were unrelated to BMI, except for an unexpected BMI-activity relationship in males. We suspect this relationship in males is primarily due to selection effects, whereby physically bigger boys, with a larger BMI, are more likely to take part in exercise activity, and possibly also to BMI being a less accurate predictor of fatness in adolescent boys.

Activities of Daily Living↗

PubMed2005

Possible association of the human KCNE1 (minK) gene and QT interval in healthy subjects: evidence from association and linkage analyses in Israeli families.

QT interval prolongation is associated with increased risk of sudden and non-sudden cardiac death. Potassium channel gene variants are associated with inherited long QT syndromes. Using linkage and association analyses, we investigated whether variants in the potassium channel subunit KCNE1 are associated with QTc intervals in an unselected population sample of 80 kindreds living in kibbutz settlements in Israel. Variance-component linkage analysis revealed weak evidence of linkage of KCNE1 polymorphisms with QTc intervals. Family-based association analysis showed a significant association between the G38S polymorphism and QTc interval. Further quantitative trait association analysis demonstrated a significant residual heritability component (h(2)= 0.33), and that the effect of the G38S variant allele is modified by gender. Estimated maximum likelihood parameters from these models indicated that male gender, age, hypertension, diabetes, hypercholesterolemia, fibrinogen and BMI were positively associated with QTc interval; level of education and cigarette smoking showed an inverse association. Both erythrocyte membrane n-6 and n-3 fatty acids showed a significant inverse association with QTc interval. While more than 15.8% of QTc variability was contributed by covariates, another 4.7% was explained by dietary factors, the G38S polymorphism explained 2.2%, and approximately 36% was explained by polygenes. An in silico analysis showed also that the novel V80 SNP, another KCNE1 synonymous variant, abolishes the recognition for a splicing enhancer, which may lead to an increased effect of the G38S mutation. These results demonstrate that, in addition to polygenic background, dietary factors and other covariables, the KCNE1 G38S variant is involved in determining QTc levels in this population-based sample of families.

Adult↗

PubMed2005

Adolescent drinking level and adult binge drinking in a national birth cohort.

AIMS: To assess (i) continuities in binge drinking across adulthood and (ii) the association between adolescent drinking level and adult binge drinking. DESIGN: Population-based prospective birth cohort. SETTING: England, Scotland and Wales. PARTICIPANTS: All births during one week in March 1958 (n = 8520 in analysis). MEASUREMENTS: Alcohol consumption reported at 16, 23, 33 and 42 years. Binge drinkers were identified by dividing number of units of alcohol consumed in the last week by usual drinking frequency, with limits of >/=10 units/occasion for men and >/=7 for women. FINDINGS: Four in five cohort members drank alcohol at least twice a month. Prevalences of binge drinking at 23, 33 and 42 years among men were 37%, 28% and 31% and among women 18%, 13% and 14%. Most binge drinkers in adulthood changed drinking status during this period. Nevertheless, binge drinking at age 23 increased the odds of binge drinking at 42 years: odds ratio (OR) 2.10 (95% CI 1.85, 2.39) for men; OR 1.56 (95% CI 1.29,1.89) for women. Women who rarely or never drank aged 16 were less likely than light drinkers (0-2 units/week) to binge drink as adults, OR at 23 years 0.65 (95% CI 0.55, 0.77). Men who were heavier drinkers (>/=7 units/week) at 16 years were more likely than light drinkers to binge drink throughout adulthood; at 42 years, OR 1.64 (95% CI 1.33, 2.08). CONCLUSIONS: Binge drinking is common in British men and women throughout adulthood with continuities between the 20s and 40s. Adolescent drinking has a modest although important association with adult binge drinking.

Adolescent↗

PubMed2004

Improved neutron detection by gamma-ray spectroscopy.

Most high-efficiency interactions for neutron detection are with thermal neutrons, and the detection of the prompt gamma radiation emitted as a result of thermal neutron absorption in specific materials was sometimes used. These materials are named converters, the most widespread being 10B, 113Cd or 73Ge (the last two materials are detector materials themselves for CdZnTe and HPGe detectors). However, for these materials, the main gamma-ray energies are relatively low (in the region 473-600 keV), and there are interferences from other gamma rays present in background. Different combinations of moderator-converter-detector systems were employed to optimise the system efficiency and signal-to-background ratio, using B, Cd, Gd and Cl converters and HPGe, NaI(Tl) and BGO detectors. When using a Cl converter, the 1164.7 keV peak seems to be a good choice when a HPGe spectrometer is used. A very practical material containing chlorine is PVC.

Environmental Exposure↗

PubMed2004

Are inequalities in height narrowing? Comparing effects of social class on height in two generations.

OBJECTIVE: To determine whether social inequalities in height change across generations. METHODS: The target population was from the 1958 British birth cohort, all born 3rd-9th March 1958, followed to 1991, and the offspring of one third of this population. Main outcomes were height measured at 7, 11, 16, and 33 years (cohort members) and once at 4-18 years (offspring). Multilevel models applied to associations of social class of origin with (a) child-to-adult growth trajectory (cohort members), (b) height (offspring), and (c) generational height increment. RESULTS: Height inequalities were observed among cohort members, with differences >2.0 cm at all ages between classes I and II, and IV and V. By adulthood, the difference in mean height had declined significantly in boys and slightly in girls. A secular trend was seen between the two generations. While male offspring had a similar mean height to their fathers in classes I and II, boys in classes IV and V gained 2.1 cm (p<0.001). Height gains of female offspring were evident in all classes, with a greater gain in classes IV and V (non-significant). The social class effect on height was weaker among offspring, with a difference between classes I and II, and IV and V of less than 1 cm. CONCLUSIONS: Social inequalities in height observed among the cohort weakened substantially in the next generation due to a greater height gain among offspring from manual classes. Inequalities in childhood height have narrowed between the two generations in this study.

Adolescent↗

PubMed2003

Industry-sponsored research on the potential health and environmental effects of selected brominated flame retardants.

Modern fire-fighting techniques, equipment and fire-resistant building design has lead to less destruction than in the previous centuries. However, a high fuel load in either a residence or a commercial building can overwhelm even the best firefighters or building construction, and factors affecting the fuel load have changed in recent decades. The fire load in a typical home has doubled over the last 50 years, furnishings typically include those made of petrochemicals that can behave as if containing built-in accelerant, and modern energy-efficient buildings are less able to disperse heat in the event of a fire. Flame retardant chemicals (FRs) are one means used to reduce the risk of fire. FRs are typically added or incorporated chemically into a polymer to slow or hinder the ignition or growth of a fire in low-to-moderate cost commodity polymers. One type of FR contains bromine atoms as the active moiety. The FR industry, either as individual companies or as consortia, has conducted a broad range of studies on the commercial deca-, octa- and pentabromodiphenyl oxide/ether, tetrabromobisphenol A and hexabromocyclododecane products. These five products have data in excess of the OECD Screening Informational Data Set (SIDS) and the U.S. High Production Volume (HPV) program, and sufficient data for the performance of formal EU risk assessments. The objective of this paper is to present the range of data developed by industry consortia and to provide sources for the information. We hope to facilitate further research by assembling references to industry consortia-sponsored research here.

Environment↗

PubMed2003

Child to adult socioeconomic conditions and obesity in a national cohort.

OBJECTIVE: Critical stages in childhood are suspected for adult obesity. We sought to identify (i) whether risk of adult obesity is influenced by childhood socioeconomic conditions in addition to those in adulthood; and (ii) whether conditions in childhood act independently or through their association with education or parental obesity. DESIGN: Longitudinal, 1958 British birth cohort. SUBJECTS: A total of 11 405 men and women followed to age 33 y. MEASUREMENTS: Social class at birth and ages 7, 11, 16, 23 and 33 y. Obesity (BMI> or =30) at age 33 y. RESULTS: Social class was related to obesity, cross-sectionally at ages 16 (women), 23 and 33 y, but not at younger ages. In analysis of adult obesity (age 33 y) and social class at five life stages, class at age 7 y significantly predicted obesity for women (adjusted odds ratio (OR)=1.31, that is, the odds increased by 31% for each decrease in social class). For men, class at birth and age 23 y predicted adult obesity (adjusted OR=1.19 and 1.16, respectively). Education was also associated with adult obesity, increasing the odds by 30% (men) and 35% (women) for each decrease in qualification level. Adjustment for education level and parental BMI did not abolish the effect on adult obesity of class at age 7 y among women, nor of class at birth among men, while class at age 23 y reduced to borderline significance. CONCLUSIONS: Cross-sectional associations for social class and obesity can be misleading and obscure effects of childhood socioeconomic conditions. Influences around birth to age 7 y have a long-lasting impact on the risk of adult obesity.

Adolescent↗

PubMed2003

Probabilistic reasoning and clinical decision-making: do doctors overestimate diagnostic probabilities?

BACKGROUND: The "threshold approach" is based on a physician's assessment of the likelihood of a disease expressed as a probability. The use of Bayes' theorem to calculate disease probability in patients with and without a particular characteristic, may be hampered by the presence of subadditivity (i.e. the sum of probabilities concerning a single case scenario exceeding 100%). AIM: To assess the presence of subadditivity in physicians' estimations of probabilities and the degree of concordance among doctors in their probability assessments. DESIGN: Prospective questionnaire. METHODS: Residents and trained physicians in Family Medicine, Internal Medicine and Cardiology (n = 84) were asked to estimate the probability of each component of the differential diagnosis in a case scenario describing a patient with chest pain. RESULTS: Subadditivity was exhibited in 65% of the participants. The total sum of probabilities given by each participant ranged from 44% to 290% (mean 137%). There was wide variability in the assignment of probabilities for each diagnostic possibility (SD 16-21%). DISCUSSION: The finding of substantial subadditivity, coupled with the marked discordance in probability estimates, questions the applicability of the threshold approach. Physicians need guidance, explicit tools and formal training in probability estimation to optimize the use of this approach in clinical practice.

Bayes Theorem↗

PubMed2003

Cigarette consumption and socio-economic circumstances in adolescence as predictors of adult smoking.

AIM: To investigate effects of cigarette consumption level and socio-economic circumstances during adolescence on adult smoking. METHODS: 1958 British birth cohort (all births 3-9 March 1958). Logistic regression used to predict (i) smoking at 41 years and (ii) persistent smoking (at 23, 33 and 41 years) from cigarette consumption and socio-economic circumstances at 16 years, indicated by social class and educational qualifications. RESULTS: Of 6537 subjects with full smoking history, 30% smoked at 16 years, 23% smoked at 41 years and 19% smoked at 23, 33 and 41 years (persistent smokers). Heavier smokers at 16, 23 and 33 years were more likely to smoke at 41 years than lighter smokers. The odds ratio (OR) of smoking at 41 years was 2.5 for men and 3.0 for women who smoked >/=60 cigarettes/week at age 16, relative to <20 cigarettes/week. Subjects from manual social backgrounds and those with no qualifications had elevated risks of being a smoker at 41 years or a persistent smoker. These effects were robust to adjustment for adolescent consumption level (e.g. adjusted OR for no qualifications was 3.8). However, adolescent consumption level modified the effect of educational achievements. Among lighter adolescent smokers, those gaining higher qualifications had lower prevalence of smoking at 41 years (16%) than men with no qualifications (83%); among heavier adolescent smokers, prevalence was more similar for subjects with higher (56%) and no qualifications (69%). CONCLUSIONS: Socio-economic background appears to influence adult smoking behaviour separately from adolescent cigarette consumption which is a recognized measure of nicotine dependence. There was some evidence that effects of early nicotine dependence are modified by educational achievements.

Adolescent↗

PubMed2003

Infant feeding and obesity through the lifecourse.

In the 1958 British birth cohort (n = 12,857 at age 7), breast feeding and BMI were unrelated in childhood. Breast feeding was protective against increased BMI at ages 16 and 33 years in females, and at 33 years in males, but this effect was markedly reduced and no longer significant after adjustment for confounding factors.

Adolescent↗

PubMed2003

Combination of low birth weight and high adult body mass index: at what age is it established and what are its determinants?

OBJECTIVE: To investigate growth trajectories and predictive factors for those with low birth weight and high adult BMI. DESIGN: Birth cohort study. SETTING: England, Scotland, and Wales. PARTICIPANTS: All born 3-9 March, 1958. MAIN OUTCOME MEASURES: People at "high risk" of adult disease were defined as having a combination of lower birth weight (in the lowest third of the distribution) and high BMI (in the highest third of the distribution at age 33). RESULTS: 284 of 3462 men and 338 of 3555 women were identified as "high risk". This group was shorter than other cohort members at age 7, on average by 1.2 cm (boys) and 1.8 cm (girls), with a deficit of about 3 cm in adult height. The "high risk" group had a similar mean weight to other subjects at age 7, but were heavier thereafter through to age 23. BMI was increased at all ages in the "high risk" group. Independent predictors include paternal BMI, maternal height and smoking in pregnancy, and social class. For each SD increase in father's BMI the odds of low birth weight/high BMI increased by about 20%. For maternal height, a 1 cm increase reduced the odds of low birth weight/high BMI by about 5%. Increased ORs for "high risk" were found for those with manual social origins (1.61 for men; 1.49 for women) and for maternal smoking in pregnancy (1.79 and 2.27 respectively). CONCLUSIONS: Maternal short stature, low social class, and smoking during pregnancy influence the development of "high risk" for adult chronic disease. The causes of high risk therefore seem to reside in utero and even earlier, in the mother's lifetime, with adverse conditions having a detrimental affect and favourable conditions protecting against high risk.

Adult↗

PubMed2002

Childhood and adulthood risk factors for socio-economic differentials in psychological distress: evidence from the 1958 British birth cohort.

Social inequalities in psychological status have been attributed to health selection and to social causation. We used data from the 1958 British birth cohort, followed over three decades, to identify causes of inequality in adulthood. Psychological status prior to labour market entry influenced inter-generational mobility, but selection effects were weaker for intra-generational mobility, between age 23 and 33. However, selection failed to account for social differences in risk of distress of approximately threefold in classes IV&V compared with I&II. Both childhood and adult life factors appeared to contribute to the development of inequalities. The principal childhood factors were ability at age 7 for both sexes and adverse environment (institutional care for men and low class for women). Adult life factors varied, with stronger effects for work factors (job strain and insecurity) for men and qualifications on leaving school, early child-bearing and financial hardship for women. Gradients in psychological distress reflect the cumulative effect of multiple adversities experienced from childhood.

Adolescent↗

PubMed2002

Gender gap in coronary artery disease: comparison of the extent, severity and risk factors in men and women aged 45-65 years.

This retrospective study aimed to characterize coronary artery disease (CAD) and its risk factors among relatively young women, as compared to men in a similar age group. Confirmed cases of CAD were compared regarding their medical background, performance and outcome of coronary artery procedures, physical profile and lifestyle information. The study population included 179 women and 270 men aged 45-65 years who were hospitalized during the study period 1990-1995 in the Hadassah Medical Centers. Significantly more women presented with histories of prior myocardial infarction and a higher number of vessels occluded by 80% or more and required percutaneous transluminal coronary angioplasty for 3 or more arteries, and the women had a higher incidence of risk factors such as diabetes, hypertension and hypercholesterolemia than their male counterparts.

Age Factors↗

PubMed2001

Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study.

OBJECTIVES: To determine the influence of birth weight on body mass index at different stages of later life; whether this relation persists after accounting for potential confounding factors; and the role of indicators of fetal growth (birth weight relative to parental size) and childhood growth. DESIGN: Longitudinal study of the 1958 British birth cohort. SETTING: England, Scotland, and Wales. PARTICIPANTS: All singletons born 3-9 March 1958 (10 683 participants with data available at age 33). MAIN OUTCOME MEASURES: Body mass index at ages 7, 11, 16, 23, and 33 years. RESULTS: The relation between birth weight and body mass index was positive and weak, becoming more J shaped with increasing age. When adjustments were made for maternal weight, there was no relation between birth weight and body mass index at age 33. Indicators of poor fetal growth based on the mother's body size were not predictive, but the risk of adult obesity was higher among participants who had grown to a greater proportion of their eventual adult height by age 7. In men only, the effect of childhood growth was strongest in those with lower birth weights and, to a lesser extent, those born to lighter mothers. CONCLUSIONS: Maternal weight (or body mass index) largely explains the association between birth weight and adult body mass index, and it may be a more important risk factor for obesity in the child than birth weight. Birth weight and maternal weight seem to modify the effect of childhood linear growth on adult obesity in men. Intergenerational associations between the mother's and her offspring's body mass index seem to underlie the well documented association between birth weight and body mass index. Other measures of fetal growth are needed for a fuller understanding of the role of the intrauterine environment in the development of obesity.

Adolescent↗

PubMed2001

Using an interactive framework of society and lifecourse to explain self-rated health in early adulthood.

This paper presents an integrated model of the determinants of adult health combining lifecourse factors and contemporary circumstances. Using the 1958 British Birth Cohort, it operationalises lifecourse influences in terms of factors from birth to age 33, which might act through latent, pathway, or cumulative effects. Contemporary circumstances are represented by variables at different levels of social aggregation: macro (socio-economic circumstances); meso (involvement in civil society functions); micro (personal social support); and intersecting (job insecurity and life control). Multiple regression models were fitted, using self-rated health at age 33 as the health outcome. To allow for temporal ordering of events, early life factors were entered first in the final model, followed by later childhood factors and, finally current factors. Self-rated health was predicted by variables representing both early and later stage of the lifecourse and also contemporary societal-level factors. The effects of childhood factors were not removed by including contemporary factors, and conversely, contemporary factors contributed to the prediction of self-rated health over and above lifecourse factors. The factors were not collinear; supporting the notion that each dimension was distinct from the others. Although the model accounted for only 9% of the variance in self-rated health, the general conclusion is that both lifecourse and contemporary circumstances should be considered together in explaining adult health.

Adolescent↗