Biomedical subjects

O Martinon

Publications and source records attributed to O Martinon.

2 recordsLinked to original sources

PubMed1994

Immunization of mice with proteins reacted with malonic dialdehyde (MDA): comparison between autologous and heterologous modified proteins.

In previous experiments, rabbits were injected with heterologous proteins reacted with MDA, and produced antibodies cross-reacting with other MDA-modified proteins (MPr), but not with the corresponding native ones (Pr). It was concluded that these antibodies (AbAIP) recognized epitopes including 1-amino-3-imino-propene (AIP) bridges resulting from reactions of MDA with primary amino groups of proteins. In the present work, mice were injected with autologous MDA-modified albumin (MAI) or with heterologous MPr. Mice immunized with MAI developed an immune response leading to an increased production of AbAIP, which clearly indicates that such a response may occur even with an autologous MPr.

Animals↗

PubMed1993

[Feline immunodeficiency virus].

Feline immunodeficiency virus (FIV) is a typical lentivirus that preferentially replicates in feline T lymphoblastoid cells and is the causative agent of a cat disease with features similar to the HIV-induced human AIDS. Its overall genetic organization is similar to human immunodeficiency virus (HIV) but the reduced complexity of the regulatory open reading frames renders FIV closer to ungulate than to primate lentiviruses. On the other hand, FIV infects both CD4+ and CD8+ T lymphocytes as well as feline B lymphocytes and macrophages. In addition, the FIV cellular receptor does not appear to be mostly constituted by the feline CD4 differentiation antigen. Nevertheless, the cat model may provide invaluable insight into the determinants of the immunodeficiency viruses pathogenesis. In addition, this model may help define novel approaches to eliciting protective immunity against HIV.

Animals↗