Biomedical subjects
Publications and source records attributed to O Martins.
The author makes a concise review of the imagiology of acute head trauma. The relative value of the various imaging techniques and the present importance of skull radiography are discussed; the role of computed tomography (CT) is emphasized. The most important aspects of traumatic lesions, as evaluated by CT, are presented.
Brain Na+ K+ ATPase activity has been found to decrease in experimental trypanosomiasis in rats infected with Trypanosoma congolense. Some physical features that affect membrane fluidity were also observed to be altered. The levels of cholesterol in the brain and free fatty acids in the serum were found to increase in the infected animals. These findings might be relevant to the development of brain lesions.
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We report one patient who developed two squamous-cell carcinomas on different parts of the lower lip. The tumors were excised by the UV technique, a variation of the V-shped excision. We repaired the defect caused by excision of the first lesion by direct closure and that caused by extirpation of the second lesion by use of a transposition flap (Abbe-Estlander technique).
Groups of male Sprague Dawley rats aged 60 days were fed either a control diet (CD) or the same diet enriched with 1% cholesterol (CHD) for 30 days. In CHD fed animals an increase of 131I uptake by thyroid, PB131I and TSH level in plasma was found, while the level of thyroxine (T4) was unchanged and that of triiodothyronine (T3) was decreased. In the animals treated with T3 (20 micrograms i.p. daily) a decrease of 131I uptake by thyroid and of T4 and TSH level in plasma was found irrespectively of a cholesterol content in the diet. However, PB131I level was decreased in CHD fed and T3 treated animals compared to those fed CD under the same treatment. Finally, in the animals treated with cimetidine (10 mg i.p. daily) no changes of any measure was found after CD feeding as compared to untreated ones, while CHD in such animals resulted in a decreased of T3 level. The site of cholesterol action appears to be at the hypothalamus-pituitary system since TSH suppressed animals (i.e. T3 treated) did not show any thyroid stimulation when fed with a cholesterol excess. Furthermore, thyroidectomized animals showed increased TSH in plasma after cholesterol feeding. In the present study, chronic administration of cimetidine completely abolished thyroid gland stimulation promoted by cholesterol feeding thus suggesting that central histamine may play a considerable role in this process.
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Two patients with one year duration post-scabious nodules are reported. Lymphoid hyperplasia was found histologically and a malignant lymphoma was suspected. Six patients with pseudolymphomatous scabious nodules were found in the literature and of these only one had evidence of lymphoid follicle formation with germinal centres. Short lived and persistent scabious nodules are discussed and diagnosis with lymphomatous nodules, dermatofibroma and urticaria pigmentosa considered. A "Darier's sign" was elicited on rubbing the lesions which is probably related to the increased number of mast cells in the infiltrate and may explain the persistent pruritus. Histological criteria to separate cutaneous lymphoplasia from lymphoma are reviewed and other more common causes of lymphadenosis benigna cutis are considered. Cutaneous lymphoplasia in persistent scabious nodules is possibly an indirect evidence of the importance of immunological factors in scabies.
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