Biomedical subjects
Publications and source records attributed to O Muşat.
The paper presents up-to-date information about the action of the tumor necrosis factor in inflammatory pathology. It underlines the fact that a new category of medicines appeared: anti-TNF monoclonal antibodies which can offer new therapeutic perspective in the treatment of intraocular inflammation.
Age related macular degeneration (ARMD) is a disease in which the retinal pigment epithelium (RPE) is damaged in the central retinal area. In the exudative form, the vision loss is due to choroidal neovascularization, while in the nonexudative or atrophic form, there is a vision loss because of the retinal pigment epithelium atrophy. Treatment which proved to be efficient in lowering the risk of severe vision loss in the exudative form includes laser photocoagulation, photodynamic therapy, transpupilary thermotherapy and as surgical treatment, the controversial subretinal membrane extraction. In all these situations the RPE is damaged by the disease itself and by the therapeutic procedure too. Retinal translocation is a surgical procedure that intends to remove the neurosensory retina from an area with damaged RPE to an healthy RPE area, through a 360 degrees retinotomy or through a limited one. This paper present some ARMD cases treated by subretinal membrane extraction and one by limited retinal translocation. The question which is still remaining is which are the risks and benefits for the following treatment procedures: laser photocoagulation, photodynamic therapy, transpupilary thermotherapy and surgical approach?
Specular microscopy has multiple advantages in the clinical practice, allowing the study of the corneal endothelium in-vivo. We can observe corneal disorders, as well as the corneal status after intraocular surgery, of the posterior pole as well as of the anterior pole of the eye.
In the beginning, the paper presents some general words about the main intraoperative complications of the phacoemulsification and some practical attitudes patient in front of the rupture of the posterior capsule. The second part presents the case of a 63 years old patient who was intended to be operated for cataract by phacoemulsification and who suffered a complication during this procedure--the rupture of the posterior capsule with the luxation of the majority of the nucleus into the vitreous body.
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We present two cases of hemangiopericytoma, which are analyzed according to medical literature, although only few cases have been reported. Clinical, imagistic and histological findings of these rare vascular tumors are discussed.
The authors analyze 13 cases of small bowel tumors. There are emphasized the difficulties of diagnosis, which is rarely established before the laparotomy. In the same time, clinical features are few and operations are often performed too late, in emergency, due to tumors complications (perforation, bleeding, occlusion). There are also presented new etiopathogenic hypothesis, recently mentioned in literature. Surgical treatment is followed by many post-operative complications. Five-years survival is low, under 40% of patients.
The lesions of the pancreas represent a very interesting chapter of its pathology. Although they seem very much alike, the different anatomo- pathological forms have well defined individual features, which impose the therapeutical attitude. The authors have analyzed a group of 62 patients, admitted in our clinic between 1974 and 2003. Most of them had pancreatic pseudocysts (54-86%); 6 (10%) had cystadenomas; 1 (2%)--cystadenocarcinoma and 1 (2%)--solid and papillary cystic tumour. The diagnostic methods are largely presented and compared to the literature; it is emphasized the importance of imaging procedures and of the histo-pathological examination. The different therapeutical procedures, their advantages and limits are also analyzed--the necessity of a conservative attitude, with the total or partial preservation of the pancreas, is almost unanimously recognized.