Biomedical subjects
Publications and source records attributed to O N Kut'kova.
It is found that local applications of the unguent with soluble collagen, but not solution of the collagen, stimulate healing of erosions and full-thickness excision wounds in the rat skin. Not all the stages of healing were stimulated, but only two of them--contraction and epithelialization.
The values of adhesion between keratinocytes as dermo-epidermal junction in the skin decreased after UV-irradiation, heating to 60 degrees C or sodium dodecyl sulfate action. The results suggest the existence of nonspecific adaptive reactions of keratinocytes adhesive interactions in response to different irritative stimulants.
The reversible prolonged increase of intercellular adhesion in the epidermis along the margins of the wound as well as in the scar epidermis during the full-thickness skin wound healing was found. This effect must have adaptive significance.
The effect of platelet-activating factor (PAF) on the leucocytes accumulation into mouse peritoneal cavity, that induced by high-molecular irritants carrageenan and polyacrylic acid pentaerytritol (carbopol) was studied. It was found that injection of PAF into peritoneal cavity one hour before i.p. injection of the irritants did not change their effects. On the contrary the injection of PAF simultaneously with the irritants or 3 and 6 hours after these injections inhibited the leucocyte accumulation into the peritoneal cavity and/or these injections increased the leucocyte adhesion to the peritoneal covering. It was supposed that finding effects are mediated by the change of leucocytes adhesion under action of PAF.
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