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O Nagy

Publications and source records attributed to O Nagy.

11 recordsLinked to original sources
PubMed2001

The effect of arterial blood sampling sites on blood gases and acid-base balance parameters in calves.

In 21 healthy calves, 1-6 months old, the interrelationship and comparability of acid-base balance variables (pH, HCO3-, BE) and blood gases (pCO2, pO2, and sat-O2) were evaluated in arterial blood collected from a larger, centrally localised (the a. axillaris) and a smaller peripheral artery (the a. auricularis caudalis). Sampling was done by direct puncture of the vessels without local anaesthesia. Except for blood pH, significant differences were observed in the average values of pCO2, pO2, HCO3-, sat-O2 (P < 0.001), and BE (P < 0.05). Analyses of blood from the a. axillaris showed higher pH, pO2, and sat-O2 values, and lower pCO2, HCO3-, and BE values compared with that from the a. auricularis caudalis. Despite statistically significant differences between some variables, in all indices high and significant correlation relationships were recorded (R = 0.928-0.961; P < 0.001). Therefore, from the biological and clinical point of view, these differences are unimportant and the presented method of peripheral arterial blood sampling can be considered suitable for evaluating blood gases and acid-base status.

Acid-Base Equilibrium↗
PubMed1994

[Acid-base profile evaluation in central and peripheral arterial and venous blood in cattle].

In veterinary medicine mainly venous blood is used for acid-base balance determinations. This blood, however, does not allow to evaluate the respiratory component, therefore arterial blood samples have to be taken and examined in cases requiring such measurements (respiratory tract diseases, assessment of the degree of compensation in disturbed acid-base conditions). For this reason, central and peripheral arterial blood samples from the a. axillaris and a. subclavia, and the a. auricularis, respectively, were taken from 14 head of cattle, and the values of selected acid-base parameters (pH, pCO2, pO2, HCO3, BE and SAT) were compared. Simultaneously, venous blood samples (v. jugularis) were also examined. Comparison of arterial and venous blood samples (Tab. I) revealed statistically significant differences in pH (p < 0.01) as well as in pCO2, pO2 and SAT values (p < 0.001). In HCO3 and BE, no significant differences were observed. Comparison of arterial blood samples in relation to sampling sites (peripheral and central) disclosed no significant differences in the single parameters; all values correlated at a high level (Tab. II, Figs. 1-6). The highest correlation levels were determined for BE (r = 0.984), HCO3 (r = 0.959), pH (r = 0.944) and pCO2 (r = 0.938) whereas those recorded for SAT (r = 0.877) and pO2 (r = 0.874) were lower. Arterial blood sampling from the a. auricularis caudalis seems to be simpler than sampling from the more central parts that are difficult to approach mainly in fat animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Acid-Base Equilibrium↗
PubMed1993

[Paroxysmal hemoglobinuria in calves and its effect on hematologic and acid-base profiles].

Water intoxication is considered to be one of the possible causes of haemoglobinuria in calves. As to predisposing factors, prognosis and particularly differential diagnosis, uncertainty is rather frequent. Therefore we tried to provoke this state in an experiment, in which the disiony-induced changes of the acid-base balance (pH, pCO2, HCO3, pO2, BE, SAT of venous blood) were determined in addition to clinical observations (general behaviour, respiratory and pulse rates, body temperatures) and blood analysis (red and white blood cells, PCV and haemoglobin). Experimental paroxysmal haemoglobinuria was induced in eight 2-months-old male calves of the Black Pied breed weighing 55-70 kg that were held on a green diet. After the animals had been given cold water (12-14 degrees C) at an amount of 12% of their body weight, increased volume of the abdominal cavity, muscle tremor, and a stooping posture could be seen, and in 45-60 min. following water administration the first spontaneous haemoglobinuria occurred. Except the first 20 minutes following water gavage, when pronounced tachycardia accompanied by arythmia (100-130 per min.) was recorded, a tendency towards hypothermy, mild bradycardia and bradypnoe was observed; correction of these values occurred within 24 hours. Haematological indices revealed a hydraemic trend that was most pronounced and long-lasting in haemoglobin. Twenty-four hours after water gavage haemoglobin, red blood cells and PCV values were still below their starting levels; the tendency toward leucopoenia changed into leucocytosis. The acid-base balance revealed a slight acidemic trend with decreasing pH, actual bicarbonate and BE levels in the first hour; later, equilibration and increase within the physiological range occurred.(ABSTRACT TRUNCATED AT 250 WORDS)

Acid-Base Equilibrium↗
PubMed1993

[Experimental paroxysmal hemoglobinuria in calves and selected biochemical indicators in the blood and urine].

When examining diseased calves, sporadically pronounced haemoglobinuria with dark red urine can be observed. In serious cases the clinical picture may be manifold but peculiar; in easy cases, however, when there are no distinct clinical symptoms, a larger scale of examinations is needed to aid differential diagnosis. Eight roughage-fed bulls aged two months, weighing 55-71 kg were used in this experiment. Selected biochemical indices of the mineral, enzymatic, hepatic, energetic and urinary profile were determined in the blood serum and urine of the animals. After the administration of cold water at an amount representing 12% of the animal's body weight, ionogram values were determined. In all indices a positive correlation with hydraemia and a decrease in Na, Cl, Ca, Mg and P levels were observed. Correction of the above levels occurred within 24 hours, with the exception of Na and P concentrations that did not reach starting values. As to the enzymatic profile (AST, ALT, GGT), no pronounced disturbances could be observed. The most profound changes were seen in AST activity that increased in the 5th hour of the experiment. A slight tendency towards hypoproteinaemia was observed to continue even in 24 hours. Hypoglobulinaemia reached its starting value in the 24th hour while simultaneously albumin levels slightly increased. The increasing bilirubin levels reached their maximum in the 5th and 6th hour; correction of the former occurred within 24 hours. The urinary profile revealed polyuria, aciduria, aquaeous urine and haemoglobinuria, the latter reaching its peak between hours 1 and 3 following water administration.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1992

[Dynamics of the acid-base balance of venous and arterial blood in clinically healthy calves].

Values of the acid base balance were examined in both venous and arterial blood of healthy calves (n = 6) of the Slovak Spotted breed aged, 3, 6, 8, 10, 12, 14, 18, and 24 weeks, respectively. Until week 4 of age the animals were fed milk only, until the age of 9 weeks a milk-roughage transition fodder and from week 10 on they were given classical herbage. Blood samples were taken from the V. jugularis and A. carotis communis or A. axillaris, respectively. The results achieved were corrected to a body temperature of 39 degrees C. During the examination period the following values were stated for both arterial and venous blood: actual acidity (pH) 7.391 +/- 0.014 and 7.362 +/- 0.013 logmolc, pCO2 6.35 +/- 0.15 and 7.35 +/- 0.11 kPa, HCO3-28.38 +/- 1.42 and 30.32 +/- 1.02 mmol. l(-1), ABE 3.57 +/- 1.44 and 4.34 +/- 1.09 mmol. l(-1); pO2 12.63 +/- 1.15 and 5.21 +/- 0.73 kPa, SAT 95.8 +/- 1.03 and 61.2 +/- 9.59%, respectively. A gradual increase in most indices of the acid base balance could be stated both in arterial and venous blood. The trends either revealed a parallel increase (HCO3-, pH) or they were more pronounced either in venous blood (SAT) or in arterial blood (ABE, pO2). Some trends were almost balanced (pCO2 and pO2 in venous blood and SAT and pCO2 in arterial blood). Thus pH, pO2 and SAT indices of the acid base balance were higher in arterial blood as compared to venous blood while pCO2, HCO3- and ABE values were higher in venous blood.(ABSTRACT TRUNCATED AT 250 WORDS)

Acid-Base Equilibrium↗
PubMed1976

Application of a simple fluorometric method on absorption of canrenone.

The absorption of canrenone, the major metabolite of spironolactone, was studied by a simple fluorometric method in 30 healthy subjects. Two different pharmaceutical formulations were compared on absorption, and only a negligible difference was found between the micronized and balled-milled form. Canrenone in both formulations was well absorbed, whereas spironolactone absorption was slower. Mattingly's fluorometric assay proved to be a simple method to evaluate the absorption of canrenone.

Canrenone↗