Biomedical subjects

O Ndoye

Publications and source records attributed to O Ndoye.

7 recordsLinked to original sources

PubMed2003

[Scintigraphic imaging of macrophages involved in lung vasoreflex: rat model].

At time of pathological situations, a pulmonary fixation of labelled substances injected by intravenous way is observed. This fixation would result from a phagocytosis of these substances by abnormal cells whose presence was induced in the endothelium: Pulmonary Intravascular Macrophages (PIM's). After activation by phagocytosis, these cells are able to secrete powerful vasoactive mediators capable of inducing cardiopulmonary accidents. Hepatic cholestase was induced in Wistar rats by ligation and section of common bile duct. The recruitment of PIM's was followed in vivo by phagocytosis scintigraphic imaging after labelled colloid injection. During the 35 days of evolution of the pathology, we observe a pulmonary fixation of the colloid agents which progresses up to 70% as well as a concomitant decease in the hepatic activity. Histologic examination showed numerous cells related to pulmonary capillaries' endothelium belonging to mononuclear phagocytes line and expressing an activated phenotype of monocytes. The scintigraphic and histological tests carried out enabled us to validate the model of induction of PIM's in rat by ligation of the choledoque one. The study of the vasoactive response via certain mediators can from now be approached, a Doppler technique on the pig aorta is being in the course of evaluation.

Animals↗

PubMed2003

[Sickle cell disease neonatal screening. First evaluation].

A neonatal screening allows a preclinical diagnosis of major sickle cell syndromes and an early management of the affected children. That would improve their life quality and expectancy. The preliminary program was set up on 518 senegalese newborn aged from 1 to 4 days, and coming from all the country ethnic groups. Isoelectrofocalisation is the test used on dried blood eluate and the positive control on citrate agar gel. 478 samples out of 518 (92.5%) have been analysed. Haemoglobinopathy have been found in 11.1% of cases, distributed as follow: heterozygoty FAS and FAC: 9%, double heterozygoty FSC: 0.2% and homozygoty FSS: 1.9%. Sickle cell neonatal screening should be imperatively implemented, with regards in economical considerations. It would be relevant to integrate it in a larger program including information, training and genetic counselling in order to avoid homozygotes birth and to lower the spread of this disease.

Anemia, Sickle Cell↗

PubMed2002

[Nodular euthyroid goitre: value of ultrasonography versus scintigraphy in the initial assessment].

PURPOSE: The aim of this study was to show that in exploration of nodular goiter with euthyroidy ultrasonography was higher than scintiscanning. MATERIAL AND METHODS: It was to show that when it was necessary to specify the topography and the number of thyroid nodules, the proportion of right results was larger with ultrasonography than with scinticanning. These proportions being respectively indicated Pe and Ps, hypothesis of search was formulated H1: Pe > Ps. Null hypothesis was written H0: Pe < Ps. Twenty three patients (21 women and 2 men with an average age of 41 years) carrying thryroïd nodules with euthyroidy had respectively undergone a scintiscanning (scintiscanning with sweeping after ingestion of iode 131) and an ultrasonography (conventional ultrasonography with a probe of 7.5 MZ) of the thyroid gland between February 26, 1996 and June 19, 1997. Per-operativedatahaving beenused as references from which the results of scintiscanning and ultrasonography were appreciated nominally, discreet: right results or false results. In this way, proportions of right and false results were collected respectively for scintiscanning and for ultrasonography, which made it possible to test null hypothesis (H0: Pe < Ps). The results were distributed on a 2 x 2 cotigence table. The chi 2 test was applied with a risk error of 5%. RESULTS: For all patients the scintiscanning found on the whole a minimum number of 39 nodules contrary with ultrasonography and surgical exploration which respectively found a minimum number of 56 and 59 nodules. Comparison of right and false results had shown a superiority of ultrasonography (17 right and 6 false) on the scintiscanning (10 right and 13 false) with statistically significant difference (P < 0.05). CONCLUSION: Ultrasonography is more precise when it is necessary to specify the number and the topography of the thyroid nodules. In addition ultrasonography is alleviating and less expensive compared to scintiscanning.

Adult↗

PubMed2001

[Ammonia-gas poisoning: respiratory troubles evaluated by functional exploration].

The objective of our research is first to evaluate the defects in the respiratory function which have been noticed among patients suffering from ammonia poisoning during the accident at the SONACOS factory of Dakar in 1992. Secondly it is to set precisely the seriousness of the problem. This retrospective study is carried out on 50 patients examined at the Physiology and Functional Exploration Laboratory of the faculty of Medicine of Dakar University from March 1993 to October 1995. These patients have been submitted to at least two respiratory functional explorations. Ten of them have been treated for two years, thus benefiting from a spirographic control of these respiratory troubles already noticed. 58 % of the patients have developed an obstruction syndrome with the following specifities : fourteen patients out of 29 revealed a serious stoppage of the bronchi, twelve had a moderate bronchial obstruction, and three showed a minor bronchial obstruction. Besides, 34 % of the patients have developed a mixed syndrome with a minor restrictive component and a severe obstructive component. 8 % of the poisoned have presented a normal lung function testing. About the localisation of the respiration disorders at the level of the bronchial system, 61 % of the patients have shown an obstruction of the proximal, medial and distal bronchi. 26 % have presented obstruction of the distal bronchi, 13 % have shown an attack at their medial and distal bronchi. 5 patients out of 10 have shown any modification in their respiratory troubles while 3 of 10 have shown significant improvement. Then 2 out of 10 have shown degradation in their respiratory problems with an extension of bronchial obstruction. The ammonia poisoning has caused serious respiratory disorders related to the general and local toxic action of ammonia on the respiratory tract, its retention at their level and its effects on the respiratory function. The severity of the patent injuries incites to issue recommendations concerning the prevention of ammonia poisoning and the quick and efficient taking charge of the casualties in case of any accidental intoxication.

Adolescent↗

PubMed2001

[Dysthyroidism after 60 years of age].

This work has been conducted on 162 subjects, aged over 60 years, living in Senegal, investigated in the Departement of Biophysics and Nuclear Medecine of Dakar for suspicion of dysthyroidism. The levels of T3, T4 and TSH US hormones were determined by a radio-immunological method. This technique, exhibiting good functionnal sensitivity and its high specificity, is likely to be beneficial to the diagnosis of dysthyroidisms. Besides, this experiment leads us to consider that the dosage of TSH remains an useful first intention examination for the old patients and could notably improve the screening of dysthyroidisms with a decrease in the cost of the investigation. However, because of the therapeutical implications, some biological profiles schould be interpreted cautiously. The equipment for the determination of the free fractions (T3 and T4) with the brought additional accuracy could allow to dismiss some diagnostci uncertainties.

Aged↗

PubMed2000

[Scintigraphic aspects of thyroid nodules investigated at the University Hospital Center of Dakar].

The authors studied the scintigraphical appearances of thyroid nodules. This study on 8 years period enabled the authors to list 876 thyroïd nodules. The scintigraphy shows: 14.05% of isofixant nodules, 10.73% of "hot" nodules, 58.44% of "cold" nodules, 16.78% of heteromultinodular goitries. The scintigraphy proved its great importance as in the diagnostic as in the way of therapy of this pathology.

Academic Medical Centers↗

PubMed2000

[Serum cortisol level variations in thyroid diseases].

This work studies the thyroid disorders impact on adrenals glands by measuring total cortisol. Radioimmunoassays of thyroid hormones and cortisol were performed in 108 subjects, aged 20-52 years, with thyroid diseases. Our results show low cortisol values (80.35 nmol/L) in 4.77% of hyperthyroids, high values in 3.57% of hyperthyroids (1348.18 nmol/L) and 12.5% of hypothyroids (969.05 nmol/L). In hyperthyroidism, thyroid hormone stimulates the secretion of 11 ceto metabolites biologically inactive, unable to slow pituitary activity, inducing an increased production of endogene cortisol. Excessive catabolism can lead to the exhausting of overstimulated adrenal glands, and therefore to a decreased cortisol. In hypothyroidism, high cortisol results of increase cortisol half life and decrease of metabolic clearance. Control mechanisms often allow normal cortisol values. These alterations in functional activity of adrenal glands, seen in nearly 10% of these subjects, sometimes command a specific attitude in diagnosis and therapy.

Adrenal Glands↗