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Biomedical subjects

O Nishimura

Publications and source records attributed to O Nishimura.

At least 55 records · Page 3Linked to original sources

Transumbilical portal vein catheterization and insulin analysis in an infant with hypoglycemia.

We performed transumbilical portal vein catheterization and sampled portal blood selectively to carry out immunoreactive insulin (IRI) analyses in a 7-month-old girl with hypoglycemia. The IRI concentration was highest in the mid-portion of the splenic vein. Although no tumor was found at surgery, 70 per cent of the caudal pancreas was resected above the superior mesenteric vein to a point determined by preoperative investigations. Pathologic examination of the resected specimen indicated nesidioblastosis. There have been no postoperative hypoglycemic symptoms. Our technique is efficacious in reaching a diagnosis of infantile hypoglycemia.

Adenoma, Islet Cell

Clinical evaluation of long-term survival after total gastrectomy.

Twenty-seven cases of long-term survival after total gastrectomy were clinically evaluated. From the standpoint of general nutrition and rehabilitation, the patients appeared to be in satisfactory condition. However, hyperchromic anemia, serum vitamin B12 deficiency, and osteoporosis were noted in some patients.

Adult

Surveillance and follow-up of patients with implanted cardiac pacemaker by telephone transmission.

A follow-up study on pacemaker function in 15 patients with implanted cardiac pacemaker has been performed by telephone transmission. The transmitting set consisting of electrocardiograph, pacemaker pulse modulator and acoustic coupler was manipulated by the patients themselves. ECG, pacemaker pulse, and pulse rate were simultaneously transmitted through 1 channel to the receiver in our clinic. Of 56 patients with pacemaker, 15 patients were surveyed by telephone transmission. In these patients battery exhaustion was detected in 3, competition in 2, and lead fracture in 1. The fact that surveillance and follow-up of the patients with implanted cardiac pacemaker could be carried out by telephone transmission as well as by clinic visitation tells us that the telephone transmission is a useful method and plays an important role in a pacemaker clinic. Moreover our study established its further usefulness in the patient's preference due to difficulties in travelling to the pacemaker clinic and in reducing patient's anxiety.

Adolescent

[Reconstruction following cardia resection using an interposed jejunal loop without mesenteric resection].

For reconstruction after cardial resection, we invented a method combining the cardial resection method of Nissen and the gastrectomy method of Tomoda. One peculiarity of this method is the reconstruction by means of a jejunal sling that becomes intercalated between esophagus and antrum without wide dissection of the mesentery. By this method, the esophageal passage is physiological and the frequency of esophageal regurgitation compared with esophagogastrostomy is diminished.

Cardia

Stimulus-secretion coupling in pancreatic acinar cells: inhibitory effects of calcium removal and manganese addition on pancreozymin-induced amylase release.

The role of Ca ions in stimulus-secretion coupling has been analysed in the isolated and perfused rat pancreas. 2. The omission of [Ca2+]O diminished but did not abolish the release of amylase in response to continuous stimulation with 5 m-u. pancreozymin (Pz)/ml. The addition of Mn2+ (1-0 mM) to this Ca-deficient environment abolished the residual release of amylase. This was followed by a complete recovery of amylase output when the control [Ca2+]O was reestablished. 3. The addition of Mn2+ (1-0 mM) to the extracellular environment containing 2-5 mM-Ca2+ reversibly inhibited the Pz-induced release of amylase. 4. A kinetic scheme based on competition of Ca and Mn at a carrier in the acinar cell membrane could quantitatively explain the effects of Ca and Mn upon the Pz-induced amylase release. 5. These results support the view that the Ca2+ influx into the acinar cells is the major contributor to the rise in [Ca2+]i which, in turn, mediates the processes in the stimulus-secretion coupling in the exocrine pancreas, and suggest that the mode of Ca influx is a facilitated diffusion.

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