[The earliest influence of contraception on the incidence of conception].
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Biomedical subjects
Publications and source records attributed to O Norgaard.
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In 1975 there were a total of 44 patients in the author's practice with a history of treatment with pecilocinum (Variotin). These patients were patch tested with pecilocinum, and seven were found to be allergic to this drug. In three of them the skin disease had been caused or exacerbated by pecilocinum. In the other four patients the allergy to pecilocinum must be regarded as an "immunological scar".
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During the period from 1950 to 1952, three patients were studied by electrophoresis according to Tiselius on account of anticomplementary activity at WR; the presence of an M-component was demonstrated. On several later occasions it was observed that this component at first seemed to remain unchanged, later it was slightly increased; repeated examinations did not give evidence of multiple myeloma. At intervals ranging from 15 to 24 years after the primary demonstration of the M-component, all three patients presented with symptoms of multiple myeloma and died within less than one year after the disease had been diagnosed. The following conclusions are drawn:(1) The preclinical phase of multiple myeloma may cover up to 24 years.(2) A presence of multiple myeloma cannot be precluded, even after follow-up throughout 24 years, in cases of the so-called "benign monoclonal gammopathy".
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