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Biomedical subjects

O O Adekunle

Publications and source records attributed to O O Adekunle.

At least 19 recordsLinked to original sources
PubMed1999

Case-controlled study of the epidemiological risk factors for breast cancer in Nigeria.

BACKGROUND: The incidence of breast cancer is increasing worldwide, more rapidly in societies that hitherto enjoyed a low incidence of the disease, such as most African countries. Most of the epidemiological data on breast cancer from Africa have been retrospective studies with propensity for bias. METHODS: This was a case-controlled study of 250 consecutive patients with breast cancer diagnosed between April 1992 and December 1995. An age- and sex-matched control group of patients with non-oncological and non-endocrine diseases was compared. RESULTS: The peak age incidence of breast cancer in the sample studied was 43 years. There was a statistically significant difference in the height and weight of the patients compared with the controls. Patients also tended to be older at first pregnancy and at first lactation, and had a higher mean number of pregnancies. The patients also tended to be of an early birth order, to have lactated less often, to have used contraceptives and to have abused alcohol compared with the controls. CONCLUSION: The incidence of breast cancer in this environment is increasing. This is partly a result of the changing demographic profile, acquisition of 'western' lifestyle, and the changing socioeconomic profile of the country.

Adult↗
PubMed1986

Colorectal cancer in adolescent Nigerians.

Colorectal cancer has its peak incidence in the sixth and seventh decades of life in the industrialised countries. However, in developing countries the mean age is in the fifth decade. The diseases has been studied in the very young in Western Countries and its unique features well documented. So far this has not been done ine Nigeria. This paper presents illustrative cases of carcinoma of the colon and rectum in the very young in some Nigerian adolescents outlines their peculiar features and postulates on the role of certa in risk factors that can have aetiologic significance in colorectal cancer in Nigerians.

Adenocarcinoma↗
PubMed1978

Synchronous leiomyosarcoma and ameboma of the rectum: report of a case.

A case of leiomyosarcoma of the rectum associated with rectal amebiasis is presented. This is the first case to be reported. Initially, amebiasis obscured the histologic diagnosis of leiomyosarcoma, but incomplete regression following a course of treatment with metronidazole aroused the suspicion of malignancy, which was confirmed on repeat biopsy. A brief review of the features of leiomyosarcoma was also undertaken.

Aged↗
PubMed1978

African histoplasmosis of the jejunum. Report of a case.

A case of histoplasmosis of the jejunum is presented. This is apparently the first reported case of African histoplasmosis primarily affecting the jejunum. Grossly, there was stricture formation together with tubercles scattered over the surface of the bowel and adjoining mesentery. Also the mesenteric lymphnodes were enlarged. It is therefore difficult to distinguish jejunal histoplasmosis from tuberculosis, carcinoma and lymphoma of the jejunum and diagnosis can only be based on the demonstration of the characteristic yeast cells from the specimen.

Adult↗
PubMed1977

Biliary lithiasis associated with ascariasis in a Nigerian woman.

We report the occurrence of gallstones and intrahepatic stones in association with ascarid invasion of the biliary tract in a 51-year-old Nigerian woman. Although biliary stones are known to be caused by products of Ascaris worms, no etiological association was demonstrable in this case. Invasion of the biliary tract by Ascaris worms is reported as rare in our environment where intestinal ascariasis is extremely common. It is suggested that the rarity is apparent rather than real and that it is important to bear this condition in mind in view of modern rapid migration of populations.

Ascariasis↗
PubMed1976

Congenital hypertrophic pyloric stenosis in Nigeria.

Thirty one infants with congenital hypertrophic pyloric stenosis seen over a five year period (1970-1974) at the University College Hospital Ibadan are reported. Most of the patients presented late. There is a much higher male predominance but a lower prevalence among Nigerian first born infants when compared with Caucasian infants. It is suggested that the condition though uncommon is not rare in African infants, and that environmental rather than genetic or racial factors may be responsible for the apparent lower prevalence.

Female↗
PubMed1975

Omental cyst associated with mesenteric tuberculosis.

A case of omental cyst associated with tuberculosis in a 12 year old Nigerian girl is presented. It is suggested that the omental cyst is lymphogenous in origin and that spread of tuberculosis led to a rapid increase in its size. A brief review of the features of omental cysts is also included.

Child↗