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Biomedical subjects

O P Kirchik

Publications and source records attributed to O P Kirchik.

5 recordsLinked to original sources
PubMed1994

[Thyroid gland function and intrapulmonary temperature in tuberculosis].

The experiment on 140 albino mice examined the relationship between the pulmonary thermogenesis and the functional activity of the hypophyseal-thyroid system at different stages of pulmonary tuberculous inflammation development, during Staphylococcus-induced pneumonia, aseptic inflammation in lung tissue. Deep abnormalities of the heat-generating function of the lung were revealed just at the early periods of specific inflammation. The degree of hypothermal reactions of lung tissue correlated with the inhibition of hypophyseal-thyroidal function at all developmental stages of a tuberculous process. The changes were rather pronounced, stable and phasic. Spontaneous regression of the tuberculous process was not accompanied by recovery in the activity of the hypophyseal-thyroidal system, despite the fact that there was a clear-cut trend to normalization of pulmonary thermogenesis.

Animals↗
PubMed1991

[The method of endobronchial thermometry in the evaluation of the activity of tuberculosis of the respiratory organs].

Local temperature reactions were studied in 72 patients with intrathoracic tuberculosis (64 of them had active tuberculosis and 8 residual pulmonary changes after prior tuberculosis). Endobronchial thermometry in the dynamics of a specific process was conducted in 7 patients with pulmonary tuberculosis. Bronchial temperature was measured during fibrobronchoscopy under local anesthesia by a device of an original design. Marked thermoregulatory disturbances were found in the bronchi which were caused by a specific active process in the lungs and were manifested in a significant decline of endobronchial temperature as compared to normal values. Clinical recovery of pulmonary tuberculosis with the development of posttuberculous fibrous changes does not cause any disturbances in local temperature reactions. The temperature level in the bronchi is significantly affected by the nature and degree of the inflammatory process in the bronchi.

Adult↗
PubMed1990

[Study of the mucociliary transport rate in evaluating the effectiveness of the treatment of suppurative endobronchitis by CO2 laser].

The rate of mucociliary transport (MCT) in dogs with an experimental pulmonary tuberculosis and concurrent suppurative endobronchitis (SEB) and just with the latter was measured. The treatment effect was achieved by an endobronchial radiation with a CO2-laser unfocused beam of 3.56 and 5.3 w/cm2 power density, and the dogs in the control group were subjected to an endobronchial introduction of furagin. A comparison of the endoscopic picture and MCT rate findings made it possible to believe that the latter index appeared to be more reliable than a visual inspection of the bronchial mucous membrane. An active specific process in the lungs brings about MCT rate inhibition while the concurrent SEB aggravates these changes to a great extent. The radiation of the bronchial mucous membrane with the CO2-laser unfocused beam produces an immediate positive effect on MCT rate normalization. Better results were observed at a power density of 3.56 w/cm2.

Animals↗
PubMed1989

[Variants of the ultrastructure of bronchial ciliary cells].

The structure of the ciliated epithelium and its regeneration under normal conditions were studied using biopsy specimens of the trachea and extrapulmonary bronchi from healthy dogs. The specimens were processed with the routine methods for electron microscopy. Along with the typical structure of the ciliated cells there were observed various deviations considered earlier as consequences of bronchopulmonary pathology: changed cytoplasm of the ciliated cells in the form of cytoplasmic processes or follicles. In their composition there were single cilia, their aggregates and secretory granules. The qualitative and quantitative changes in the cilia were in the form of cilia with excessive cytoplasm, cilia aggregates included in a common cuticula, etc. It was suggested that the changes in the ultrastructure of the bronchial epithelium reflected a definite stage of the cell development and represented the normal state variants.

Animals↗