Biomedical subjects

O Pavel

Publications and source records attributed to O Pavel.

11 recordsLinked to original sources

PubMed1985

Plasma and cerebrospinal fluid concentrations of magnesium in epileptic children.

In order to discriminate between conflicting reports in the literature, plasma and cerebrospinal fluid magnesium levels from epileptic children were compared with those of control children. To exclude the possibility of methodological artifacts, two methods for Mg determination were used: atomic absorption spectrophotometry and a colorimetric procedure. By both methods a significantly decreased concentration of Mg in plasma was found in epileptics. A positive correlation of the hypomagnesemia with the severity of epilepsy was found: the more severe the epilepsy, the lower was the plasma Mg. A significant increase of Mg concentration in CSF of epileptics was found. The most likely origin of Mg in CSF in epilepsy is the CNS tissue from which Mg is released. It is suggested that these alterations of Mg concentrations in plasma and CSF originate from a functional impairment of the cell membranes which might occur in epilepsy.

Adolescent↗

PubMed1984

Serum concentration of Na, K, Ca, Mg, P, Zn and Cu in patients with essential arterial hypertension.

Serum concentration of Na, K, Ca, Mg and inorganic phosphate as well as serum levels of Zn and Cu were determined in control subjects and in patients with essential arterial hypertension (EAH) divided according to the stage of the disease. No significant differences were found between the serum mean levels of Na, K, Ca, Mg, Zn and Cu in controls and in patients with EAH. A significant decrease of the serum Zn was noted in the third stage of EAH. A number of cases with hypomagnesemia and/or hypopotassemia probably caused by a long term uncontrolled therapy was also detected. The concentration of inorganic phosphate was significantly lower in patients with EAH associated with overweight than in hypertensive patients with normal body weight and in controls. It is considered that a sustained study of the complex interrelationship between electrolyte interaction and the functional aspects of the arterial wall could still contribute to a better understanding of pathogenic aspects of EAH and of its complications including those subsequent to modern diuretic therapy.

Adult↗

PubMed1982

Effect of propranolol on hypophosphatemia in overweight.

A negative correlation was found in 54 hypertensive overweight patients between the excess body weight and the level of serum inorganic phosphorus. The effect of propranolol upon the serum concentration of phosphorus, sodium, potassium, calcium and magnesium in 20 of the above mentioned patients as well as in five normal weight, normotensive subjects was studied. After 10 d of treatment with propranolol (160-240 mg/24 h) the concentration of serum phosphate rose from 0.76 +/- 0.02 mmol/l to 0.98 +/- 0.06 mmol/l (P less than 0.02) in the 20 overweight hypertensive patients and remained unchanged in the five control subjects with initial normal phosphate levels. No propranolol induced changes of other serum electrolytes was noted. There is no obvious explanation of the above mentioned findings. An increased uptake of glucose and inorganic phosphate by the enlarged adipose tissue and an impairment of this mechanisms by propranolol might be however suggested.

Adult↗

PubMed1974