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Biomedical subjects

O Pettirossi

Publications and source records attributed to O Pettirossi.

11 recordsLinked to original sources
PubMed1978

Anti-arcing loop and resectoscope.

A new modified cutting loop assembly and a modification of the resectoscope to prevent arcing between the bare wire loop and the distal end of the telescope are described.

Electrosurgery↗
PubMed1977

En bloc transplantation of the liver, pancreas, duodenum, spleen, and kidney in the rat.

Five organs consisting of the liver, pancreas, duodenum, spleen, and kidney from (Lewis X Brown Norway)F1 rats were transplanted simultaneously as an en bloc graft to Lewis recipients. No immunosuppression was given postoperatively. Serial laporatomies were performed for macroscopic examination and biopsies of the grafts. Macroscopically, the first evidence of rejection was splenic enlargement followed by fatty metamorphotic change of the liver, dilation and loss of peristalsis of the duodenum, and injection of the pancreas. The kidney maintained normal color and consistency until late in the rejection process. Histological examination suggested that the liver and the spleen may be more vulnerable to immune attack, since in these organs cellular infiltration started earlier and was more extensive in comparison to other organs. While the pancreas exhibited a typical, although somewhat delayed rejection pattern, the kidney seemed to maintain a well preserved structure. Interestingly, the duodenum showed no significant cellular infiltration throughout the postoperative period of examination despite severe mucosal destruction.

Animals↗
PubMed1977

The importance of continuous pump suction in TUR hydraulic hemostasis.

An intravesicoprostatic hydrostatic pressure below 10 mm Hg maintains normal anatomy and physiology of the muscular and vascular prostatic structures by continuous pump suction. An increase of the hydrostatic intravesicoprostatic pressure above 10 mm Hg produces a distortion in the musculature of the prostate, especially at the true capsule, opening the cut vessels, making possible the absorption of the irrigant free of electrolytes (TUR syndrome). A low hydrostatic intravesicoprostatic pressure permits the compression of cut vessels by the inflow hydraulic pressure of 90 cm H2O achieving hydraulic hemostasis during TURP reducing the bleeding and operative time by more than 50% and making hemostasis easier. In our last 400 TURs, blood transfusions have been unnecessary. Less electrocoagulation is required, resulting in a more rapid recovery.

Endoscopy↗
PubMed1977

[Total colectomy in the rat : its metabolic and functional consequences].

A number of total colectomies with end-to-end ileo-rectal anastomosis was performed in the inbred Lister rat. The following data were studied: survival rate, body weight curves, variations of appetite, thirst and diuresis, daily weight and electrolytes content of feces, intestinal transit time, histology of terminal ileum, rectum, liver and kidney. After an initial lose of body weight, rats gained their original weight at about two months after colectomy; at this time a syndrome was observed caracterized by anemia, leucocitosis with neutrophilia, ipoproteinemia, remarkable increase of thirst (up to 400%) and of water and sodium content of feces; appetite and diuresis were normal; intestinal transit tice was slightly reduced. Histologically there was a "coloni" transformation of the terminal ileum and vacuolization of the proximal renal tubules.

Anemia↗
PubMed1977

[Metabolic and histological changes induced in the rat by massive resection of the small intestine].

The aim of this paper was o study the long-term changes induced in the rat as a consequence of a 90% resection of small intestine. At 6 months after operation the surviving rats were stable and showed: hypoproteinemia, hyperlipemia, and a decrease of bile flow, total lipids, and cholesterol of bile. What residual intestine concern there was an increase in length and size, and decreased transit time; stomach, duodenum and colon too showed increase size. Histologically there was hypertrophy of villi, regressive changes of pancreas and kidney, as well as deposit of iron in the kidney. The reasons for these changes are discussed.

Animals↗
PubMed1976

Differential survivals of F1 hybrid allografts in parental recipients.

Differential survival times of various organ allografts in the rat across the same histocompatiblity barrier were studied by transplanting the kidney, heart, intestine, pancreas, and skin from (BN X Le)F1 hybrid donors to Lewis recipients. Some (one-third) of the kidney grafted rats survived for a prolonged period of time (32-72 days, plus one rat surviving over 9 months), whereas all other organs and skin were promptly rejected between 7 and 21 days. Possible factors responsible for the prolonged kidney survival are discussed; the reason for this was not clear but was not related to the period of operative ischemia or postoperative blood-urea-nitrogen, nor were animals tolerant to donor antigen as evidenced by the popliteal lymph node weight assay and signs of mild rejection on histology of grafted kidneys. A hypothesis of autoenhancing mechanism is presented.

Animals↗
PubMed1976

Prolongation of rat heart allograft survival by a synthetic progestogen (melengestrol acetate) and ara-cytidine acylates.

Immunosuppressive effects of newly developed synthetic progestins, melengestrol acetate (MGA), and three pyrimidine analogs, ara-cytidine (Ara-C), Ara-C 5'-benzoate and octanoate, were investigated on the heart allograft survival in the rat. MGA at the dose of 25 mg/kg given every 3rd day starting 1 day before the grafting through day 20 prolonged the graft survival significantly without toxic effects (80.2 +/- 40.2 days versus control 7.0 +/- 0.1 days). The high dose (50 mg/kg/day) was more effective (137.4 +/- 26.6 days) but a high incidence of multiple abscesses (37%) was also noted. The other three agents were either highly toxic or not immunosuppressive.

Animals↗