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O Piro

Publications and source records attributed to O Piro.

17 recordsLinked to original sources
PubMed2001

Quasiperiodic patterns in boundary-modulated excitable waves.

We investigate the impact of domain shape on wave propagation in excitable media. Channeled domains with sinusoidal boundaries are considered. Trains of fronts generated periodically at an extreme of the channel are found to adopt a quasiperiodic spatial configuration that repeats periodically in time. The phenomenon is numerically studied in a model for a photosensitive Belousov-Zabotinsky reaction. Spatial return maps for the height and position of the successive fronts are analytically obtained, and reveal the similarity between this spatial quasiperiodicity and the temporal quasiperiodicity appearing in forced oscillators.

Journal Article↗
PubMed2001

Complex Ginzburg-Landau equation in the presence of walls and corners.

We investigate the influence of walls and corners (with Dirichlet and Neumann boundary conditions) in the evolution of two-dimensional autooscillating fields described by the complex Ginzburg-Landau equation. Analytical solutions are found, and arguments provided, to show that Dirichlet walls introduce strong selection mechanisms for the wave pattern. Corners between walls provide additional synchronization mechanisms and associated selection criteria. The numerical results fit well with the theoretical predictions in the parameter range studied.

Journal Article↗
PubMed2001

Pitch perception: a dynamical-systems perspective.

Two and a half millennia ago Pythagoras initiated the scientific study of the pitch of sounds; yet our understanding of the mechanisms of pitch perception remains incomplete. Physical models of pitch perception try to explain from elementary principles why certain physical characteristics of the stimulus lead to particular pitch sensations. There are two broad categories of pitch-perception models: place or spectral models consider that pitch is mainly related to the Fourier spectrum of the stimulus, whereas for periodicity or temporal models its characteristics in the time domain are more important. Current models from either class are usually computationally intensive, implementing a series of steps more or less supported by auditory physiology. However, the brain has to analyze and react in real time to an enormous amount of information from the ear and other senses. How is all this information efficiently represented and processed in the nervous system? A proposal of nonlinear and complex systems research is that dynamical attractors may form the basis of neural information processing. Because the auditory system is a complex and highly nonlinear dynamical system, it is natural to suppose that dynamical attractors may carry perceptual and functional meaning. Here we show that this idea, scarcely developed in current pitch models, can be successfully applied to pitch perception.

Acoustic Stimulation↗
PubMed2000

Stochastic spatiotemporal intermittency and noise-induced transition to an absorbing phase

We introduce a stochastic partial differential equation capable of reproducing the main features of spatiotemporal intermittency (STI). The model also displays a noise-induced transition from STI to laminarity as the noise intensity increases. Simulations and mean-field analysis are used to characterize this transition and to give a quantitative prescription of its loci in the relevant parameter space.

Journal Article↗
PubMed2000

Endogenous tissue factor pathway inhibitor modulates thrombus formation in an in vivo model of rabbit carotid artery stenosis and endothelial injury.

BACKGROUND: Tissue factor pathway inhibitor (TFPI) is the sole known inhibitor of the extrinsic coagulation pathway of physiological importance; however, its role in modulating thrombosis in vivo is still unclear. METHODS AND RESULTS: Intravascular thrombosis was initiated by placing an external constrictor around endothelially injured rabbit carotid arteries (n=10). Carotid blood flow velocity was measured by a Doppler flow probe. After placement of the constrictor, cyclic flow reductions (CFRs), due to recurrent thrombosis, developed at the site of stenosis. Transstenotic TFPI plasma activity was measured in blood samples before induction of CFRs and after 30, 60, and 180 minutes of CFRs. TFPI plasma activity distal to the site of thrombosis was significantly lower than the corresponding proximal values at 30, 60, and 180 minutes of CFRs. In addition, a progressive decrease in TFPI plasma activity was observed in both the proximal and the distal samples, indicating consumption of TFPI during thrombus formation. In 10 additional rabbits, CFRs were abolished by administration of aspirin (10 mg/kg). In the animals in which aspirin abolished CFRs, endogenous TFPI was depleted by a bolus of a polyclonal antibody against rabbit TFPI, and the effects on restoration of CFRs were monitored. In 5 of 6 animals in which aspirin abolished CFRs, depletion of endogenous TFPI activity caused full restoration of CFRs. CONCLUSIONS: The data of the present study support the involvement of endogenous TFPI in the process of thrombus formation in vivo and its active role in modulating arterial thrombosis.

Animals↗
PubMed2000

Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits.

Oxygen free radicals induce de novo synthesis of tissue factor (TF), the initiator of the extrinsic pathway of coagulation, within the coronary vasculature during postischemic reperfusion. In the present study we wanted to assess whether TF expression might cause myocardial injury during postischemic reperfusion. Anesthetized rabbits underwent 30 min of coronary occlusion followed by 5.5 h of reperfusion. At reperfusion the animals received 1) saline (n = 8), 2) human recombinant, active site-blocked activated factor VII (FVIIai, 1 mg/kg, n = 8), or 3) human recombinant activated FVII (FVIIa, 1 mg/kg, n = 8). FVIIai binds to TF as native FVII, but with the active site blocked it inhibits TF procoagulant activity. The area at risk of infarction (AR), the infarct size (IS), and the no-reflow area (NR) were determined at the end of the experiment. FVIIai resulted in a significant reduction in IS and NR with respect to control animals (28.1 +/- 11.3 and 11.1 +/- 6.1% of AR vs. 59.8 +/- 12.8 and 24.4 +/- 2.7% of AR, respectively, P < 0.01), whereas FVIIa resulted in a significant increase in IS and NR to 80.1 +/- 13. 1 and 61.9 +/- 13.8% of AR, respectively (P < 0.01). In conclusion, TF-mediated activation of the extrinsic coagulation pathway makes an important contribution to myocardial injury during postischemic reperfusion.

Amino Acid Chloromethyl Ketones↗
PubMed1999

Frozen spatial chaos induced by boundaries.

We show that rather simple but nontrivial boundary conditions could induce the appearance of spatial chaos (that is stationary, stable, but spatially disordered configurations) in extended dynamical systems with very simple dynamics. We exemplify the phenomenon with a nonlinear reaction-diffusion equation in a two-dimensional undulated domain. Concepts from the theory of dynamical systems, and a transverse-single-mode approximation are used to describe the spatially chaotic structures.

Journal Article↗
PubMed1999

Emerging antithrombotic treatments for acute coronary syndromes.

In the last few years the hypothesis of coronary thrombosis, frequently triggered by plaque ulceration or fissuration, has gained wide acceptance as one of the key events in the pathophysiology of acute coronary syndromes. Plaque ulceration may activate both platelets and the coagulation cascade via exposure of a variety of substances, such as von Willebrand factor and tissue factor. It has been demonstrated that aspirin reduces mortality and improves the prognosis of patients with such syndromes. More recently, newer drugs have been identified for the treatment of acute coronary syndromes; in particular, platelet glycoprotein IIb/IIIa inhibitors have been found to be more effective than aspirin in a variety of clinical conditions, such as unstable angina, acute myocardial infarction, and coronary angioplasty. Other drugs with different mechanisms of action will be soon available for large scale clinical trials.

Acute Disease↗
PubMed1989

Evidence for chaotic behavior in driven ventricles.

Toad ventricles were externally driven by periodic pulses while monophasic action potential (MAP) signals were recorded in seven excised and seven in situ ventricles. As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of periodic behavior, like phase-locking and period-doubling sequences leading to chaos, were observed. Results showed that subharmonic bifurcations (order one and two) and chaotic-like behavior may systematically occur in the MAP signal within a definite frequency interval in the 1:1 phase locking regime. The chaotic, or more cautiously expressed, chaotic-like behavior is characterized by the power spectrum, the autocorrelation function, the Poincaré map, and the reconstructed 2-D phase portrait. It is concluded that (a) bifurcations of order one and two and the characteristic irregular behavior are evidences of local universal chaotic dynamics in cardiac tissue; (b) there are no qualitative differences in the dynamics of the in situ and excised ventricles; and (c) fibrillation seems to be related to chaotic behavior, but whether they are similar or equivalent phenomena still remains to be seen.

Animals↗