Cardiac metastasis of rectal adenocarcinoma diagnosed by two-dimensional echocardiography.
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Biomedical subjects
Publications and source records attributed to O Polis.
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This article introduces bidimensional echocardiography. The main sections are reviewed. A brief comparison between M-mode and 2 D echocardiography is proposed showing that the two techniques are really complementary to one another. Judging by the many applications of M-mode echocardiography in recent years, one may safely expect considerable developments for the bidimensional echocardiography which, in its very first steps, already appears irreplaceable.
The final picture of left ventricular failure depends at least as much upon its four mechanisms of compensation (increase in preload, in afterload, in heart rate and, as an attempt, in myocardial contractility) as upon its primary factor (decrease in contractility). The complexity of all possible combinations between those various factors has good chances to bring about confusion in therapeutics if one doesn't dispose of a method, a kind of Ariane's thread, making it possible (1) to define some wide orientations to start with, and thereafter (2) to state precisely the way out of that labyrinth. This method must be founded on an accurate physiological basis and therefore requires cardiac catheterization. In all cases the purpose is to get an adequate cardiac output with comfort to the patient and at a low cost to his myocardium. Further adjustment of that treatment essentially founded on hemodynamics, must however take into account its uncertain physiological results in various organs, estimated from clinical and biological information.
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The purpose of this work is to settle biometrical and physiological factors linked to changes in ejection time in aortic valvular disease. The relationship between the various considered variables is submitted to multivariate statistical analysis, and expressed by a prediction formula. Data are provided by a series of 160 aortic patients whose examination notably includes measurement of cardiac output and of pressures in left ventricle and aorta, a cineangiography in the ascending aorta, and a search for aortic valvular calcifications with an image intensifier. Moreover, the already published results of a reference series of 200 subjects without aortic disease, are also used. Multivariate relationship of ejection time appears to be, on the whole, similar in the reference series and in the aortic series, with besides, in the latter, a significant effect of aortic "gradient" and incompetence. Consequently these two marks of aortic disease may be indirectly predicted from the residuals of the reference formula applied to aortic patients.
The purpose of this work is to reconsider practical value of three prediction formulae of left ventricular ejection time (LVET): the Wood's coefficient, the Weissler's residual and the multivariate residual. Two series of patients are presented: (1) an aortic series of 160 patients, with pure or nearly pure stenosis in 46 cases, pure insufficiency in 57 cases, and stenosis plus insufficiency in 57 cases, and (2) a reference series of 200 patients without aortic disease. All the patients were catheterized, with measurement of cardiac output by Fick's method. In all the aortic patients, the aortic "gradient" was measured, the amount of aortic regurgitation assessed by cineangiography, and the presence of absence of aortic valve calcification checked with an image intensifier. LVET tends to increase according to the importance of the "gradient" and of the insufficiency. However, the isolated use of this increase as a predictor of severity of aortic lesions is not more rewarding than just looking for aortic valve calcification except in pure aortic insufficiency. Sensitivity or specificity of the prediction can be increased by various combinations of both observations--LVET and calcification--; their respective interest will depend upon the target. Probability of false positive or negative predictions can be estimated in both series of patients and in various subgroups of aortic lesions. False negative predictions have been analysed in patients with pure or nearly pure stenosis and a "gradient" of 50 mm Hg or higher . Based on any of the three LVET predictions formulae, they are chiefly observed in the absence of calcification--i.e. in younger patients--probably because stenosis here is less severe. Based on the Wood's or Weissler's coefficient, false negative predictions are also relatively frequent in patients with a decreased stroke volume; this doesn't occur if the LVET prediction formula takes stroke volume into account, as in the multivariate residual. Three types of patients with pure or nearly pure stenosis and a "gradient" of 50 mm Hg or higher can be described: (a) without calcification and with a normal stroke volume: the patient is young, his stenosis is moderately severe, and LVET tends to increase but most often remains within normal limits; (b) with calcification and a normal stroke volume: the patient is notably older, his stenosis is severe, and LVET is most often increased; (c) with calcification and a decreased stroke volume at rest, which suggests a decreased myocardial performance; here, age and stenosis are similar to the preceding subgroup observations, but LVET is often normal if stroke volume is not taken into account.
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Total drainage of systemic blood into the left atrium is an exceptional finding in absence of severe intracardiac malformation. In our patient, a boy 3 years and 4 months old, the left superior vena cava, the inferior vena cava, and the coronary sinus drained into the left atrium; there was no right superior vena cava, and the only associated anomaly was a large atrial septal defect. This rare form of cyanotic congenital heart disease was correctly diagnosed and successfully corrected.
In patient with severe coarctation of the aorta, arterial pressures were similar at the four limbs due to departure of both subclavian arteries from the descending aorta. The clinical clues to the diagnosis and the hemodynamic, angiocardiographic and surgical data are presented.
The relationship between left ventricular ejection time, and physiological or biometrical data, is submitted to multivariate statistical analysis. Methodology is intended to attain three objectives: 1) to simulate a controlled-condition experiment in clinical research, by using the statistical method of multiple regression; 2) to get a wide inference of conclusions, by selecting a sample of two hundred subjects whose biological data cover a wide field; 3) to check the really prospective value of results, by applying the formula worked out in a group of a hundred subjects to another independent group of a hundred subjects. The prediction formula of ejection time takes into account: stroke volume, cardiac cycle duration, body height, sex, age, pulse pressure, blood capacity in oxygen, presence or absence of digitalis treatment or atrial fibrillation. The first aim of the formula is to better evaluate the normal relationship between considered variables. Secondarily it leads to a proposal for estimating mechanical performance of the left ventricle.
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