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O Puciłowski

Publications and source records attributed to O Puciłowski.

35 records · Page 2Linked to original sources
PubMed1982

Rotational behavior produced by unilateral ventral noradrenergic bundle lesions: evidence for a noradrenergic-dopaminergic interaction in the brain.

In this study the effect of unilateral electrocoagulation of the ventral noradrenergic bundle (VB) on rotational behavior produced by dopaminergic agonists was investigated. Unilateral lesions to the VB produced a decrease in the concentration of noradrenaline but not dopamine, serotonin or 5-hydroxyindoleacetic acid (5-HIAA) in the ipsilateral part of the forebrain. These lesions produced also strong and dose-dependent preference for ipsilateral rotation after systemic injection of apomorphine or amphetamine. The results are discussed in terms of possible interaction between noradrenergic and dopaminergic systems and it is proposed that the VB plays a regulatory role in the function of brain nigro-striatal dopaminergic system.

Amphetamine↗
PubMed1982

Effect of 6-hydroxydopamine-induced lesions of A10 dopaminergic neurons on aggressive behavior in rats.

The present study evaluated the effects of microinjections of 6-hydroxydopamine into the ventral mesencephalic tegmental area (nucleus A10) on aggressive behavior in rats. This treatment resulted in a reduction in foot-shock-induced fighting but failed to influence muricide (mouse-killing) behavior in chronically isolated rats. The general activity of animals tested in the open field was significantly increased two weeks after lesions. These behavioral changes were accompanied by a significant depletion of forebrain dopamine, with no difference between lesioned and sham-lesioned rats in norepinephrine and 5-hydroxyindole acetic acid levels.

Aggression↗
PubMed1982

MIF-1 facilitates passive avoidance retention.

MIF-1 (Pro-Leu-Gly-NH2) is an endogenous substance which seems to be involved in the regulation of some central nervous system functions. It was recently shown to affect learning and memory processes. In order to further clarify the role of MIF in these processes we used two different passive avoidance tests: one-trial step down (SD) and shock suppressed drinking (SSD). Z-Pro-Leu-Gly-NH2 was administered on the training day ip either 15 minutes before trial or immediately after. The doses used were as follows: SD--1.0 mg/kg, SSD--0.05 mg/kg (in the group injected before trial) and 1.0 mg/kg--SD and SSD, in the groups injected post-trial. Only the immediate post-training injection of peptide resulted in significant prolongation of the step-down latencies on the retention-day. Similarly, in the SSD procedure only post-training MIF markedly attenuated water intake on the day after training. In a separate experiment we have found that in the dose of 1.0 mg/kg, but not 0.1 mg/kg, MIF significantly inhibited water intake. These results suggest that this naturally occurring peptide can contribute to the processes of memory consolidation and water intake.

Animals↗
PubMed1981

Effects of stimulation of the raphe nuclei on muricide behavior in rats.

Mouse-killing behavior was induced in male Wistar rats by chronic isolation. Selective stimulation of the dorsal raphe nucleus markedly reduced this aggressive behavior. On the other hand, stimulation of the median raphe nucleus produced no changes in muricide behavior. Our results indicate that dorsal and median raphe nuclei function differentially in the regulation of muricide behavior with the dorsal raphe playing a critical role in this behavioral pattern.

Aggression↗
PubMed1981

Some behavioral effects of chlorodesmethyldiazepam and lorazepam.

Two benzodiazepine derivatives, chlorodesmethyldiazepam (CDD) and lorazepam (LOR) were compared in rats and mice in some behavioral tests. Both compounds similarly depressed audiogenic seizures, facilitated the behavior suppressed by punishment (conflict test) and produced muscle relaxant and sedative effects as measured in a rota-rod test. In low and moderate doses CDD paradoxically increased shock-induced fighting while in a higher dose it strongly reduced this behavioral pattern.

Acoustic Stimulation↗
PubMedDate not supplied

The effect of oxytocin and fragment (MIF-I) on the development of tolerance to hypothermic and hypnotic action of ethanol in the rat.

The daily pretreatment of rats with oxytocin (OXY) or MIF-I prior to ethanol (Et-OH) administration markedly altered the alcohol tolerance when tested on the fifth day of treatment. OXY (800 and 2400 nmole/kg SC) and MIF (800 nmole/kg SC) inhibited the development of tolerance to the hypnotic effect of Et-OH. MIF at this dose also inhibited the tolerance to the hypothermic effect. Only OXY in the dose of 800 nmole/kg suppressed hypothermia in an acute experiment with Et-OH and produced by itself hypothermia after acute administration (2400 nmole/kg). The tolerance to this last effect developed after four days of peptide treatment. The results indicate that OXY and MIF-I can influence the processes of development of tolerance to some central depressive effects of Et-OH in rats.

Animals↗
PubMedDate not supplied

Inhibition of affective aggression and dominance in rats after thyrotropin-releasing hormone (TRH) microinjection into the nucleus accumbens.

The effect of 10 micrograms TRH injected bilaterally into the nucleus accumbens septi on two models of affective aggression and on dominance in a water-competition task was investigated in pairs of male Wistar rats. TRH significantly suppressed affective shock-induced and apomorphine-induced fighting. It also decreased dominance when administered to dominant rats while no effect was noted upon injection into subordinate animals. The peptide influenced neither water consumption in thirsty rats nor the pain threshold in a hot plate test.

Affect↗
PubMedDate not supplied

Activity of diltiazem and nifedipine in some animal models of depression.

The effect of two calcium channel inhibitors, diltiazem and nifedipine in animal models of depression: a) behavioral despair test and b) behavioral deficit produced by uncontrollable footshock was investigated. Additionally, the influence of both drugs on mouse killing (muricide) behavior induced by chronic isolation was studied. Both drugs given in single doses increased the active behavior of rats in behavioral despair test. Nifedipine but not diltiazem was partially effective in the test when administered chronically (14 days). Both drugs also attenuated stress-induced behavioral depression in the open field and forced swim test. Diltiazem was markedly more active in the former whereas nifedipine in the latter test. Neither compound influenced killing behavior in muricidal rats. Our data support the notion that calcium channel inhibitors may possess antidepressant activity, although there appear to exist certain differences in their scope of action depending on the model applied.

Animals↗
PubMedDate not supplied

Enhanced apomorphine-induced fighting in rats after prolonged oral treatment with drugs altering noradrenergic transmission.

Male Wistar rats were given orally for seven days water, clonidine (0.125 or 0.25 mg/kg bid) or S3341, a new clonidine-like drug (2.5 or 5.0 mg/kg bid) and afterwards pairs of rats were injected ip with 2.5 mg/kg of apomorphine (APO). Water-treated animals did not behave aggressively. Clonidine and S3341 both induced clear aggression when combined with a subthreshold dose of APO. Some degree of hyperirritability developed in these two groups during drug treatment when observed in the home-cage. No significant changes in aggressive behavior were noted upon acute administration of both drugs, though some tendency to augment aggressivity could be observed after clonidine (0.25 mg/kg po). It is suggested that noradrenergic neurons play an inhibitory role in APO-induced fighting.

Aggression↗
PubMedDate not supplied

Effects of 6-hydroxydopamine-induced lesions of A10 dopaminergic neurons and neuroleptic or bromocriptine treatment on ethanol withdrawal syndrome in rats.

In this study we have investigated the possible role played by dopaminergic mesocorticolimbic neurons in ethanol withdrawal syndrome in rats. 6-hydroxydopamine-induced bilateral lesions of A10 nucleus resulted in selective fall in forebrain dopamine content accompanied by enhanced motor activity and audiogenic seizure intensity when measured during withdrawal period. Opposite changes, hypolocomotion and lower seizures intensity, were observed after metoclopramide injection. Pimozide also diminished seizure intensity but at higher dose (0.4 mg/kg) produced an increase in locomotor activity. Bromocriptine, an agonist of dopaminergic receptors, depressed both locomotor activity and audiogenic seizure intensity. It is concluded that mesolimbic dopaminergic neurons may be involved in the mechanism of ethanol withdrawal syndrome.

Animals↗
PubMedDate not supplied

Effect of lesions of the brain noradrenergic systems on amphetamine-induced hyperthermia and locomotor stimulation.

Amphetamine-induced hyperthermia and increase of locomotor activity were studied in Wistar rats with bilateral electrolytic lesions of the locus coeruleus (LC) and ventral noradrenergic bundle (VB). The hyperthermic effect of 5 mg/kg i.p. of d,l-amphetamine was reduced by VB lesion but not by lesion involving selectively the LC. Both lesions significantly reduced the stimulatory action of amphetamine on the locomotor activity. These data indicate that both LC and VB are involved in amphetamine-induced locomotor stimulation. On the other hand, amphetamine hyperthermia can be dissociated from the effects on locomotion as regards the involvement of the brain noradrenergic systems.

Amphetamine↗