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Biomedical subjects

O R Smales

Publications and source records attributed to O R Smales.

15 recordsLinked to original sources
PubMed1993

Flunitrazepam in terminal care.

Flunitrazepam is a benzodiazepine of long half-life with sedative, anxiolytic, muscle relaxant and anticonvulsant properties. It has proved effective in controlling terminal agitation, confusion, restlessness, dystonia and fitting in adults and can be given by subcutaneous infusion in combination with other drugs. Its use in children during their terminal illness is described. Good symptom control without excessive sedation was achieved over the 24 h prior to death.

Child↗
PubMed1981

Renin and angiotensin levels in children.

Plasma renin activity, plasma renin concentration, and angiotensin II levels were measured in 63 normal children aged between 2 months and 12 years. The results showed that the high levels of renin and angiotensin II present in infancy remained above adult levels throughout the first decade of life but that there was a decline with age. Boys less than 8 years old had lower plasma renin activity and angiotensin II levels than girls of a similar age; this may be due to a relative substrate deficiency. Serum urea levels were inversely correlated with plasma renin activity in both sexes. A significant inverse relationship was found between both plasma renin activity and angiotensin II, and serum sodium in the girls; a similar, although not statistically significant, relationship was seen with plasma renin activity in the boys. An inverse correlation was found between plasma renin concentration and diastolic blood pressure for the group as a whole.

Aging↗
PubMed1978

Surma and lead poisoning.

Blood lead concentrations were measured in 62 Asian children, of whom 37 had definitely had surma applied to their eyes and 25 were thought not to have done. The mean concentration in those who had not used surma was 0.98 +/- SD 0.42 mumol/1 (20.3 +/- 8.7 microgram/100 ml) compared with 1.65 +/- 0.68 mumol/4 (34.2 +/- 14.1 microgram/100 ml) in those who had. Analysis of 29 different samples of surma showed 23 of them to be composed largely of lead sulphide. We conclude that the use of surma is associated with high blood lead concentrations. In our cases most of it had been obtained abroad, and hence government restrictions might be ineffective in limiting its use: a better method of prevention might be to inform the leaders of Asian communities of the risks.

Asia↗
PubMed1978

Simple method for measuring oxygen consumption in babies.

A simple open-circuit method for measuring the rate of oxygen consumption in the neonatal nursery is described and preliminary results on 240 infants reported. The findings are consistent with previous studies using closed systems and artificial environments. The variation between one infant and another was great, which makes it difficult to predict for any one infant the thermal environment at which the rate of oxygen consumption will be minimal.

Body Temperature Regulation↗
PubMed1978

Thermoregulation in babies immediately after birth.

The fall in body temperature that occurs in babies soon after birth is influenced by the baby's weight and its environmental conditions. The rate of oxygen consumption 1 1/2 hours after birth was unrelated to body temperature and only slightly raised, indicating a limited thermogenic capacity. A radiant heater effectively prevented cooling in babies kept with their mothers in the delivery room. Washing soon after birth caused a significant cooling. Healthy term babies were found to have a limited thermogenic response to a cool environment over the first 12 hour of life and efforts to limit heat losses should be concentrated on this period.

Birth Weight↗
PubMed1978

Effect of phototherapy on thermal environment of the newborn.

Oxygen consumption was studied in 40 newborn babies undergoing phototherapy for hyperbilirubinaemia, both when enclosed within an incubator or nursed in an open cot. Exposure to phototherapy caused a rise in temperature at the mattress surface. This could result in overheating a baby nursed in an incubator, but by contrast is likely only partially to compensate for the loss of insulation of an unclothed baby in an open cot.

Humans↗
PubMed1978

Metabolic response to cold in the newborn.

Blood concentrations of glycerol and free fatty acids were measured in healthy and sick 5-day-old infants during and after cold exposure. In apparently similar infants in similar circumstances, the blood concentrations varied widely. Although the concentrations of both glycerol and free fatty acids tended to be higher during cold exposure, it is not possible to use either as an index of cold exposure in individual infants.

Blood Glucose↗
PubMed1977

A study of factors affecting blood pressure and angiotensin II in newborn infants.

Blood pressure has been measured using the Doppler ultrasonic technique in 144 infants in the first 11 days of life. Venous angiotensin II levels measured by radioimmunoassay were determined in 75 of these babies. Highly significant correlations were found between systolic blood pressure and gestational age and body weight. AII was inversely related to blood pressure and significantly related to birth weight. Babies with respiratory distress were found to be significantly hypotensive and to have markedly raised AII levels.

Angiotensin II↗
PubMed1977

Role of routine investigations in children presenting with their first febrile convulsion.

To assess the role of routine investigations in children presenting with their first febrile convulsion, the results of investigations carried out in 328 children over a 2-year period were reviewed. Lumber puncture was performed in 96% of cases and resulted in the detection of 4 cases of unsuspected meningitis, one of which was bacterial. 2 children had normal lumbar punctures on admission but developed meningococcal meningitis within 48 hours. Sugar, calcium, urea, and electrolyte estimations, and blood counts were commonly performed but were unhelpful. We suggest that lumbar puncture in those children presenting with their first febrile convulsion under the age of 18 months is the only useful routine investigation.

Age Factors↗
PubMed1976

Calcium, magnesium, and glucose levels in blood and CSF of children with febrile convulsions.

Levels of calcium, magnesium, and glucose were measured in the blood and cerebrospinal fluid (CSF) of children with febrile convulsions. Calcium and magnesium levels were within the normal range and the blood: CSF ratios were similar to those of normal subjects. Hyperglycaemia was a frequent finding and was reflected in raised CSF glucose levels. Blood glucose levels were only transiently raised and none of the children had diabetes mellitus.

Blood Glucose↗