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Biomedical subjects

O Richard

Publications and source records attributed to O Richard.

At least 91 records · Page 5Linked to original sources
PubMed1989

[Echography of the flexor tendons of the fingers].

The accuracy of high-resolution real-time ultrasonic examination of the flexor tendons of the fingers was tested in a retrospective study of 27 patients treated surgically. In ruptured tendons (8 cases) the method proved sensitive and specific, except in cases of partial rupture. Ultrasound made it possible to distinguish between extrinsically developed palmar masses (8 cases) and masses involving the tendons (4 cases). A fluid collection inside the tendon sheath was detected in 5 cases of tenosynovitis, without false-positive results. The post-operative follow-up of surgically treated tendons (2 cases) was easier with ultrasound.

Adolescent↗
PubMed1989

[Ultrasonic study of the soft tissues of the hand. I. Study technic and normal anatomy of the palm].

Ultrasound enables a worthwhile static and dynamic study of the soft tissues of the hand, provided that a high-resolution real-time is used. Accurate examinations are feasible after a several months of training because of the difficulty of the anatomy. The authors, studying 200 normal hands, describe their technique based upon the use of a 7.5 MHz multifocused linear phased-array real-time transducer and the normal ultrasonic anatomy.

Fingers↗
PubMed1988

CT-diskography in the evaluation of the postoperative lumbar spine. Preliminary results.

Thirty-three patients with recurrent sciatica after lumbar-disk surgery were studied for recurrent herniated nucleus pulposus (HNP) by CT alone and CT-diskography (CTD). Twenty-six patients underwent surgical reexploration allowing correlation with CTD. CTD made a correct diagnosis of recurrent HNP in twenty-one patients showing an extravasation of the contrast medium from the disk space into the medullary canal. In two cases CTD was positive for recurrent HNP but surgery showed only fibrosis. The amount of contrast leak was very small in these two cases along the posterior common longitudinal ligament, and the junction with the disk was very narrow. Because of their clinical presentation three patients with negative studies were operated upon. One showed only fibrosis and the two others showed an associated disk fragment. Among the twenty-one true-positive cases, seven showed a combination of recurrent HNP and scarring. Contamination of CSF by the contrast medium through the dura was observed in two patients. Although a prospective comparative study between CTD and IV-contrast-enhanced CT is necessary, CTD appears to be a useful diagnostic procedure for recurrent HNP after surgery of the lumbar spine.

Adult↗
PubMed1987

[Major beta-thalassemia and bone marrow allograft. Two cases and a study of the literature].

A 5 year 9 month-old boy has received a bone marrow allograft for beta-thalassaemia major. Conditioning included busulfan: 16 mg/kg, cyclophosphamide 200 mg/kg and a (6 Gy) thoracoabdominal irradiation. After a 16 months follow-up, the child is currently in complete remission without treatment with all the markers of his donor. His 9 year-old sister has been allografted for beta-thalassaemia major, with the same conditioning regimen. After engraftment, rejection occurred at day 85 with severe aplastic anaemia. A second graft was performed with the same donor without engraftment and the patient died at day 18 of pneumonitis. A review of the literature is proposed and the ethical choices are discussed.

Bone Marrow Transplantation↗
PubMed1987

[The lesser omentum. Normal aspect and tumor pathology in ultrasonography and x-ray computed tomography].

The lesser omentum is a peritoneal partition that can be divided into two portions: superior or gastrohepatic ligament and inferior or duodenohepatic ligament, although differentiation is sometimes difficult. Ultrasound and CT scan imaging allowed perfect definition of vascular and glandular elements contained in the omentum, and normal morphology is described. Masses developing between the two leaves of which it is constituted usually project in front of adjacent vascular structures and/or prolonged into the liver hilum, and a fatty layer separates them from large prevertebral vessels. These different guidelines allow them to be distinguished from retroperitoneal celiomesenteric adenopathies. These expansive processes are almost always of glandular origin secondary to primary digestive, retroperitoneal, pelvic and even bronchial tumors. In contrast, primary tumors are rare in this region.

Humans↗
PubMedDate not supplied

Interference between central dopaminergic stimulation, and adrenal secretion in normoxic or hypobaric hypoxic rats.

Previous data have established that postsynaptic stimulation of central dopaminergic receptors was mainly involved in the protective action of apomorphine against the comportmental consequences of hypobaric hypoxia in rats: disturbances in a conditioned avoidance response. We confirm this notion showing that domperidone (a peripheral dopaminergic blocking agent) does not antagonize the protective effect of apomorphine. Furthermore, we establish that the action of apomorphine is at least partially mediated by adrenal glands since it is no longer seen in adrenalectomized rats. In normal rats, apomorphine enhances the corticosterone increase which is observed during hypobaric hypoxia and decreases the hypoxia-induced elevation of the adrenaline level. It is therefore concluded that the anti-hypoxic activity of apomorphine is probably mediated by a centrally mediated dopaminergic modification of the adrenal response to hypobaric hypoxia.

Adrenal Glands↗
PubMedDate not supplied

[Effects of nicergoline on artificially induced micturition in the rabbit with and without prostatic hypertrophy].

An original experimental model of prostatism is proposed: Prostatic hypertrophy was induced in rabbit by testosterone 5 mg/kg-1. Three days later an increased number of micturitions, a correlate decrease in volume and an increased premictionnal vesical pressure were observed during a perfusion of the bladder in situ by NaCl 1 ml min-1. Phenoxybenzamine was not deeply studied because a lack of satisfaisant dose action-curve. I.V. administration of low doses of nicergoline (50 to 250 mcg/kg-1) reduced the consequences of the induced prostatic hypertrophy on the micturitions. These results are considered as a confirmation of a greater number of alpha 1-adrenoceptors in the bladder than in detrusor and allow us to confirm the use of nicergoline as a medical treatment of urinary retention in prostatic hypertrophy.

Animals↗
PubMedDate not supplied

[Vaccination against hepatitis B in immunosuppressed children. Apropos of 31 personal cases].

Anti HbS antibody levels were retrospectively studied in 31 children who received at least 4 immunisations with HEVAC vaccine. Results were as follow: 305 mUI/l (6 immunocompetent patients), 263 mUI/l (4 patients with solid tumors of therapy), 26 mUI/l (16 acute leukemias receiving intermittent reinduction therapy), 0.7 mUI/l (3 acute leukemias on maintenance therapy), 0 mUI/l (2 patients allografted for severe aplastic anemia, on immunosuppressive therapy). Antibody levels of patients who received immunisation during reinduction therapy were not correlated with intervall between immunisation and previous or next reinduction, not correlated with intervall from start of therapy, but seemed inversely correlated to age at time of diagnosis and at time of immunisation.

Child↗
PubMedDate not supplied

[Study of the hyo-thyro-epiglottic space by ultrasonography].

The pre-epiglottic space is located superficially at the junction of the larynx, oropharynx and hypopharynx. When it is invaded by a neighbouring cancer, the latter rises to stages 3 or 4 of the TNM classification. The space is explorable by percutaneous ultrasonic scanning of the neck. The present paper gives the first description of the normal sonographic anatomy of the pre-epiglottic space, based on 16 healthy volunteers. It also gives the first description of invasion of that space, based on 18 patients operated upon for ENT (ear, nose and throat) cancers. In 5 of these 18 patients, invasion of the pre-epiglottic space was proven at histology. There were 3 positive and no false negative results, but 3 false positive results were obtained at the beginning of the series. The accuracy of ultrasounds in this study was 83 per cent.

Aged↗