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O Rotaru

Publications and source records attributed to O Rotaru.

10 recordsLinked to original sources
PubMed1994

Histopathologic investigations of acute and subchronic toxicities of some organotin compounds in chickens.

The acute and subchronic oral toxicities of 4 organotin derivatives were investigated in chickens. The LD50 values oscillated between 200 and 400 mg/kg bw and revealed a moderate or weak toxicity. Subchronic dosing with 2 doses from each compound at 2 and 10 mg/kg bw induced dose-dependent lesions seen at necropsy and histologic examinations. Involution of the thymus and bursa Fabricius, fatty degeneration of the liver, and nephrotic syndromes were the most evident effects. The butyltin derivatives induced more drastic lesions than did the phenyltins.

Animals↗
PubMed1982

[Experimental induction of uterus tumours by modification of localised vascularization].

Present knowledge of aetiopathogenesis of uterus fibroma is based on clinical observation and backed up by pathologico-anatomic laboratory studies. In some cases, tumours were experimentally induced to animals by oestrogenic stimulation. -- The vascular factor was considered to be of minor and unspecific importance to fibroma genesis, in the context of findings so far obtained. Clinical observations, however, suggested that certain vascular disorders in genital organs provided predisposition to tumour development. Rheographic and pelvophlebographic investigations have shown that uterus fibroma has always been accompanied by pelvic congestion. - These insights prompted the authors to undertake experimental studies into the role played by the vascular factor in the genesis of uterus fibroma. Oestrogenic stimulation was used to induce uterus tumours in guinea pigs, following artificially generated vascular changes, such as ischaemia and stasis.

Animals↗
PubMedDate not supplied

Morphopathological findings in dog's acute toxoplasmosis.

Toxoplasmosis was clinically diagnosed in two dogs of 4 and respectively 18 months. A seven-day treatment remained inefficient and the animals died. Autopsy revealed a global inflammation of the lung, with necrotic lesions of bronchial lymph nodes and acute hyperplastic reaction of the spleen. Histologically, there were identified a diffuse, serofibrinous inflammation of the lung with necrotic foci, fibrinoleucocytic and necrotic exudate of bronchial and portal lymph nodes, small necrotic or fibrinonecrotic foci of the liver and spleen, lymphoglial foci and edema at the base of the cerebellum. In myocardium, as well as in the above mentioned organs, toxoplamas are free or accumulated in cysts. Inoculation of infected lung material into mice and newborn dogs gave positive results.

Animals↗
PubMedDate not supplied

Malignant melanomas in farm animals.

Malignant melanomas in 5 horses, 1 calf, 1 cow and 2 pigs were described. The disease, in white or gray horses, was tegumentally located and generalized in the organs of the abdominal cavity. Microscopically, dendritic and fusiform pigment cells and multinucleated cells were identified. In the hypophysis there microcysts and in one case a hypophyseal adenoma were encountered. Electronmicroscopically, differentiated melanophores and melanophages were also found. The mature melanosomes were intensely black and the elementary granules concentrically and lamellarly arranged. In cattle, the generalized visceral malignant melanomas were described in one calf and one cow, the latter presenting cerebral localizations, too. In swine, the malignant melanomas were observed in a Duroc with visceral generalization and in a Bazna with cutaneous localization.

Animals↗