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Biomedical subjects

O S Bulgakova

Publications and source records attributed to O S Bulgakova.

At least 19 recordsLinked to original sources
PubMed1989

[A prospective multiyear study of the course of chronic recurrent pancreatitis].

It was established during observation over time (within the period from 10 to 12 years) that the overwhelming majority of patients with chronic cholecystopancreatitis and primary chronic pancreatitis progressed to a different degree to enzyme-secreting pancreatic failure according to the pancreozymine tests. At the same time in 2/5 of all the cases, enzyme-secreting failure turned out substantial by the end of the indicated period. During the years of prospective studies, every tenth patient with chronic pancreatitis developed secondary diabetes mellitus. The degree of pancreatic enzyme secretion and carbohydrate metabolism abnormalities depended on the number of disease exacerbations suffered by the patient. Secondary gastroduodenal ulcers occurred in 27 out of 647 patients observed over time, and all the cases were associated with a considerable reduction of pancreatic bicarbonate secretion (according to the secretin test). Pancreatogenous pleural exudate was recorded in 1.4% of all the cases of chronic pancreatitis. During the observation period, 16 out of the 647 patients died from chronic pancreatitis associated with progressive exocrine pancreatic failure and malabsorption.

Adult↗
PubMed1989

[Symptomatic diabetes mellitus in patients with chronic recurrent pancreatitis].

Out of 279 patients with chronic recurrent cholepancreatitis 34 (12.2%) developed secondary diabetes mellitus. The secondary genesis of the diabetes was suggested in view of its origin in the presence of chronic pancreatitis and absence of hereditary predisposition, concomitant diseases promoting diabetes onset. The frequency of pancreatitis exacerbations and the degree of pancreatic exocrine insufficiency correlate with the occurrence of symptomatic diabetes. Diminished blood levels of insulin and C-peptide, inhibited response to pancreozymin registered in the patients may be indicative of symptomatic diabetes onset. Ketoacidosis was recorded in 9 patients, diabetic retinopathy in no patients. Ten patients out of 34 patients with chronic pancreatitis with secondary diabetes, 9 of which had episodes of ketoacidosis, received insulin. The sequence chronic cholecystitis-pancreatitis-diabetes was discussed in detail.

Adult↗
PubMed1986

[Results of the clinical assessment of the pancreotropic properties of pharmacological preparations based on the pancreozymin test].

Altogether 259 tests with intravenous injection of pancreozymin (0.5 Units/kg) were made with and without administering the drugs. It was discovered that isadrin, dopamine, complamin, calcium gluconate, euphylline and papaverine stimulated the pancreatic secretion of lipase and trypsin. It was also found that atropine, the beta-adrenoreceptor blocker propranolol and corinfar, a calcium antagonist, consistently inhibited the pancreatic secretion of the enzymes. All those drugs did not favour the escape of the pancreatic enzymes to the blood according to the criterion of trypsinemia. Administration of prednisolone in a single dose or in courses enhanced the pancreatic secretion of the enzymes, while the increased trypsinemia was only noticed in solitary cases. All the data obtained during studies of the pancreotropic properties of the drugs administered in single doses or in courses are discussed from the stand-point of the clinical significance of the findings.

Cholecystokinin↗
PubMedDate not supplied

[Insulin activity of the blood, the action on it of various loads and the effect of blood serum on the effect of insulin relative to fatty tissue in chronic pancreatitis].

In patients with chronic pancreatitis a decrease in insulin activity of blood was observed. The activity was tested using preparations of diaphragm and epididymal fat of rats. Reaction of the insulin activity of blood, after loading with glucose, secretine and pancreosimine, was also decreased. The phenomenon was probably important for development of decreased tolerance to carbohydrates, which was observed in patients with chronic pancreatitis. In blood serum of the patients no effect of inhibition of the insulin activity could be observed by means of influence of insulin on lipolysis in epididymal rat adipose tissue. The data obtained suggest that in chronic pancreatitis the leading role in development of carbohydrate metabolism impairements belonged to the quantitative insufficiency of insulin, but not to the qualitative alterations in blood serum, where the ability to inhibite the insulin activity appeared.

Adipose Tissue↗