Biomedical subjects
Publications and source records attributed to O S Jorgensen.
Quantitative immunoelectrophoresis of rat brain synaptic proteins following a series of electroconvulsive stimulations demonstrated changes suggestive of an increase in the number of synaptic vesicles, in a preparedness for glycolytic demands, and a delayed development of a certain area in the brain. The increased synaptic remodeling may be important for the action of electroconvulsive therapy.
The immunochemical properties of in vitro reassembled microtubules were investigated by immunoelectrophoretic techniques. The tubulin dimer gave no measurable immunochemical response, but the tubulin oligomer, the tau-factor and an antigen of about 135 000 daltons all gave precipitating antibodies. Those four proteins were investigated in reassembled microtubules, in DEAE-cellulose purified tubulin, and after molecular sieve chromatography of disassembled and NaCl-dissociated microtubules. Reconstitution of tubulin oligomer from tubulin dimer and tau-factor was also performed. The presence of a unique antigenic structure on tubulin oligomer which was not found in the dissociated components and the role of this aggregate as a nucleation center or intermediate in the assembly of microtubules is discussed.
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The synaptic membrane protein D2 was measured in the cerebrospinal fluid (CSF) of manic-melancholic patients. The concentration of D2 increased with the age of the patients until about 35 years of age. No difference was found between the D2-concentration in CSF from a control group compared with different manic-melancholic subgroups. The D2-concentration in CSF collected from the patients during depression or mania was compared with CSF collected from the same patients when their moods were normalized. In the case of the depressed patients, we found that the D2-concentration increased slightly when the mood was normalized.
Previously we demonstrated an approximately 20% loss of nerve cells in the basal ganglia of rats following treatment with perphenazine enanthate 3.4 mg/kg s.c. every 2nd week during 12 months. If the treatment period was only 2 or 3 months no significant differences were found.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.